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| 1 | Neuroendocrine,epigenetic,and intergenerational effects of general anesthetics显示文摘The progress of modern medicine would be impossible without the use of general anesthetics(GAs).Despite advancements in refining anesthesia approaches,the effects of GAs are not fully reversible upon GA withdrawal.Neurocognitive deficiencies attributed to GA exposure may persist in neonates or endure for weeks to years in the elderly.Human studies on the mechanisms of the long-term adverse effects of GAs are needed to improve the safety of general anesthesia but they are hampered not only by ethical limitations specific to human research,but also by a lack of specific biological markers that can be used in human studies to safely and objectively study such effects.The latter can primarily be attributed to an insufficient understanding of the full range of the biological effects induced by GAs and the molecular mechanisms mediating such effects even in rodents,which are far more extensively studied than any other species.Our most recent experimental findings in rodents suggest that GAs may adversely affect many more people than is currently anticipated.Specifically,we have shown that anesthesia with the commonly used GA sevoflurane induces in exposed animals not only neuroendocrine abnormalities(somatic effects),but also epigenetic reprogramming of germ cells(germ cell effects).The latter may pass the neurobehavioral effects of parental sevoflurane exposure to the offspring,who may be affected even at levels of anesthesia that are not harmful to the exposed parents.The large number of patients who require general anesthesia,the even larger number of their future unexposed offspring whose health may be affected,and a growing number of neurodevelopmental disorders of unknown etiology underscore the translational importance of investigating the intergenerational effects of GAs.In this mini review,we discuss emerging experimental findings on neuroendocrine,epigenetic,and intergenerational effects of GAs. | Anatoly E Martynyuk Ling-Sha Ju Timothy E Morey Jia-Qiang Zhang | 2020 | World Journal of Psychiatry2020，10，5： | 2 |
| 2 | Weight length re- lationships of littoral to lower slope fishes from the western Mediter-ranean显示文摘 | MOREY G MORANTA J MASSUTI E | 2003 | Fish Res2003，62，1： | 1 |
| 3 | Micmalgae growth-promoting bacteria as ‘helpers’ for microalgae: a novel approach for removing ammonium and phosphorus from municipal wastewater显示文摘 | de-Bashan L E Herandez J P Morey T | 2004 | Water Research2004，38，2： | 1 |
| 4 | Effects of encapsulated niacin on metabolism and production of periparturient dairy cows 显示文摘 | MOREY S D MAMEDOVA L K ANDERSON D E | 2011 | Journal of Dairy Science2011，94，10： | 1 |
| 5 | Proton pump inhibitor use and association with spontaneous bacterial peritonitis in patients with cirrhosis and ascites 显示文摘 | Siple Jolene F Morey Jessica M Gutman Tracy E | 2012 | The Annals of Pharmacotherapy2012，46，10： | 1 |
| 6 | Inhibition of bone formation during space flight显示文摘 | Morey E R Baylion D J | 1978 | Science1978，201，4361： | 1 |
| 7 | Synthesis and char- acterization of iron-substituted hydroxyapatite via a simple ion- exchange procedure显示文摘 | Kramer E R Morey A M Staruch M | 2013 | J Mater Sci2013，48，2： | 1 |
| 8 | Anesthetic properties of a propofol microemulsion in dogs 显示文摘 | Morey T E Modell J H Shekhawat D | 2006 | Anesth Analg2006，103，4： | 1 |
| 9 | Effects of encapsulated niacin on metabolism and production of periparturient dairy cows 显示文摘 | Morey S D Mamedova L K Anderson D E | 2011 | J Dairy Sci2011，94，10： | 1 |
| 10 | Continuous infraclavicular brachial plexus block for postoperative pain control at home:a randomized,double-blinded,placebo-controlled study显示文摘 | ILFELD B M MOREY T E ENNEKING F K | 2002 | Anesthesiology2002，96，： | 1 |
| 11 | Hypospadias:acontemporary epidemiologic assessment显示文摘 | Gallen tin e ML Morey AF Thompson IM Jr | 2001 | Urology2001，57，： | 1 |
| 12 | Weight-length relationships of littoral to lower slope fishes from the western Mediterranean显示文摘 | MOREY G MORANTA J MASSUTI E | 2003 | Fisheries Research2003，62，1： | 1 |
| 13 | Environmental Policy When Market Structure and Plant Locations are Endogenous 显示文摘 | Markusen J R E R Morey N Olewiler | 1993 | Journal of environmental Economics and Management1993，，24： | 1 |
| 14 | Coiorimetric detection of chemical warfare simulants显示文摘 | Wallace K J Morey J Lynch V M Anslyn E V | | 0，，： | 1 |
| 15 | Theprevalenceofselfreported deliberate self harm in Irish adolescents显示文摘 | Morey C Corcoran P Arensman E etal | 2008 | BMCPublic Health2008，，8： | 1 |
| 16 | Competition in Regional Environmental Policies When Plant Locations are Endogenous 显示文摘 | Markusen J R E R Morey N Olewiler | 1995 | Journal of Public Economics1995，56，1： | 1 |
| 17 | Foraminiferal faunal estimates of paleotemperature: circumventing the no-analog problem yields cool ice age tropics显示文摘 | MIX A C MOREY A E PISIAS N G | 1999 | Palaeoceanography1999，14，3： | 1 |
| 18 | Inferential sensor for on-line monitoring of ammonium bisulfate formation temperature in coal-fired power plants显示文摘 | SI F ROMERO C E YA Z XU Z MOREY R L LIEBOWITZ B N | 2009 | Fuel Processing Technology2009，90，： | 1 |
| 19 | Clinical utility of the reticulocyte haemoglobin content in the diagnosis of iron deficiency 显示文摘 | Alan E Mast Morey A Blider | | Clinical Themistry0，48，7： | 1 |
| 20 | Microalgae growth promoting bacteria as helpers' for microalgae : a novel approach for removing ammonium and phosphorus from municipal wastewater 显示文摘 | De - Bashan L E Herandez J P Morey T | 2004 | Water Research2004，38，2： | 1 |
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