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| 1 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 2 | Method of delivery and pregnancy outcomes in Asia: the WHO global survey on maternal and perinatal health 2007–08显示文摘 | Pisake Lumbiganon Malinee Laopaiboon A Metin Gülmezoglu Jo?o Paulo Souza Surasak Taneepanichskul Pang Ruyan Deepika Eranjanie Attygalle Naveen Shrestha Rintaro Mori Nguyen Duc Hinh Hoang Thi Bang Tung Rathavy Kang Chuyun Kannitha Cheang Mario Festin Venus | 2010 | The Lancet2010，，9713： | 2 |
| 3 | Diffusion tensor MR imaging of the brain and white matter tractography显示文摘 | Melhem ER Mori S Mukundan G | 2002 | AJR2002，178，1： | 1 |
| 4 | Surface-grafted hyperbranched polymers via sel-condensing atom transfer radical polymerization from silicon surfaces显示文摘 | Mori H Boker A Krausch G | 2001 | Macromolecules2001，34，20： | 1 |
| 5 | Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia显示文摘 | Saleh MN Mori PG | 1989 | Blood1989，73，： | 1 |
| 6 | Determination of nitrate and nitrite in mixtures with a nitrate ion electrode 显示文摘 | Morie G P Ledford C J Glover C A | 1972 | Anal Chim Acta1972，60，2： | 1 |
| 7 | Low-temperature fabrication and electrical property of 10 mol %Sm2O3-doped CeO2 ceramics显示文摘 | Wang Y R Mori T Li J G | 2003 | Sci Tech Advanced Mater2003，4，： | 1 |
| 8 | Corrosion properties of Co-based cemented carbides in acidic solutions 显示文摘 | SUTTHIRUANGWONG S MORI G | 2003 | International Journal of Refractory Metals and Hard Materials2003，21，34： | 1 |
| 9 | Anaerobic treatment ofvegetable tannery wastewaters:a review显示文摘 | Mannucci A Munz G Mori G | | 0，，1： | 1 |
| 10 | Determination of ammo nia in tobacco and tobacco smoke with an ammonia e leetrode显示文摘 | SLOAN C H MORIE G P | 1974 | Anal Chem Aeta1974，69，1： | 1 |
| 11 | Diffusion tensor MR imaging of the brain and white matter tractography显示文摘 | Melhem ER Moris S Mukundan G | 2002 | AJR2002，178，8： | 1 |
| 12 | Monitoring protein kinase activity in cell lysates using a high-density peptide microarray 显示文摘 | HAN Xiaoming YAMANOUCHI G MORI T | 2009 | J Biomol Screen2009，14，3： | 1 |
| 13 | Determination of nitrogen oxides in cigarette smoke with a nitrate ion electrode显示文摘 | Sloan C H Morie G P | 1974 | Tob Sci1974，18，： | 1 |
| 14 | Disulfide structure of alfimeprase:a recombinant analog of fibrolase显示文摘 | Jones G Ronk M Mori F | 2001 | Protein Science2001，10，： | 1 |
| 15 | Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons显示文摘 | DEL ZOPPO G J SCHMID-SCHONBEIN G W MORI E | 2001 | Stroke2001，21，： | 1 |
| 16 | Powdered activated carbon and membrane bioreactors (MBRPAC) for tannery wastewater treatment: long term effect on biological and filtration process performances 显示文摘 | Munz G Gori R Mori G | 2007 | Desalination2007，207，11213： | 1 |
| 17 | Malignant glomus tumour:a case report and review of the literature显示文摘 | De Chiara A Apice G Mori S | | 0，，02： | 1 |
| 18 | Antimicrobial and antioxidant activities of unripe papaya 显示文摘 | OSATO J A SANTIAG L A REMO G M CUADRA M S MORI A | 1993 | Life Science1993，53，： | 1 |
| 19 | Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg 2576 mouse model of Alzheimer's disease显示文摘 | Mori T Koyama N Arendash G W | 2010 | Glia2010，58，3： | 1 |
| 20 | Diffusion tensor MR imaging of the brain and white matter tractography显示文摘 | Melhem ER Moris S Mukundan G | 2002 | A JR2002，178，8： | 1 |
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