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| 1 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 2 | 糖化血红蛋白与口服葡萄糖耐量试验在产后糖尿病筛查中的作用显示文摘妊娠期糖尿病(GDM)患病率不断提高,这些患者产后发生糖耐量异常、T2DM风险明显提高,而且GDM史是心血管疾病预测因素。因此,重新评价其产后糖代谢状态非常重要。糖代谢状态筛查方式上,过去10年中ADA一直在不断更新。由于OGTT操作较为复杂,简便易行的空腹血糖更受推崇,但患者仍需禁食至少8h后方可进行检测。因此,无需空腹状态的HbA1c现在已成为最被推荐的方式。基于此,本研究旨在评价HbA1c(单独或联合空腹血糖)对判断有GDM病史的患者产后糖代谢状态的作用。 | 吴红花 Picón MJ Murri M Muoz A | 2012 | 中国糖尿病杂志2012，20，12： | 3 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease显示文摘Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD) and is defined as an excessive accumulation of scar tissue in the intestinal wall. Intestinal fibrosis occurs in both forms of IBD: ulcerative colitis and Crohn’s disease. Small-molecule inhibitors targeting hypoxia-inducing factor (HIF) prolyl-hydroxylases are promising for the development of novel antifibrotic therapies in IBD. Herein, we evaluated the therapeutic efficacy of hydroxamate of betulinic acid (BHA), a hypoxia mimetic derivative of betulinic acid, against IBD in vitro and in vivo. We showed that BAH (5–20 μM) dose-dependently enhanced collagen gel contraction and activated the HIF pathway in NIH-3T3 fibroblasts;BAH treatment also prevented the loss of trans-epithelial electrical resistance induced by proinflammatory cytokines in Caco-2 cells. In two different murine models (TNBS- and DSS-induced IBD) that cause colon fibrosis, oral administration of BAH (20, 50 mg/kg·d, for 17 days) prevented colon inflammation and fibrosis, as detected using immunohistochemistry and qPCR assays. BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, α-SMA) and inflammatory markers (F4/80+, CD3+, Il-1β, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. BHA displayed promising oral bioavailability, no significant activity against a panel of 68 potential pharmacological targets and was devoid of genotoxicity and cardiotoxicity. Taken together, our results provide evidence that oral administration of BAH can alleviate colon inflammation and colitis-associated fibrosis, identifying the enhancement of colon barrier integrity as a possible mechanism of action, and providing a solid rationale for additional clinical studies. | María EPrados Adela García-Martín Juan DUnciti-Broceta Belén Palomares Juan ACollado Alberto Minassi Marco ACalzado Giovanni Appendino Eduardo Muñoz | 2021 | Acta Pharmacologica Sinica2021，42，7： | 3 |
| 5 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 6 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 7 | A comparative evaluation of microalgae for the degradation of piggery wastewater under photosynthetic oxygenation显示文摘 | Ignacio de Godos Virginia A. Vargas Saúl Blanco María C. García González Roberto Soto Pedro A. García-Encina Eloy Becares Raúl Mu?oz | 2010 | Bioresource Technology2010，，14： | 2 |
| 8 | Goal programming approach to maintenance scheduling of generating unit in large scale power systems显示文摘 | Andrés Ramos | 1999 | IEEE Trans on Power Systems1999，14，3： | 1 |
| 9 | Mobilization of phosphorus from iron ore by the bacterium Burkholderia caribensis FeGL03显示文摘 | Delvasto P Ballester A Mu(n)oz J A | | 0，，01： | 1 |
| 10 | Synthesis and study of the crystallographic and magnetic structure of the ferromagnetic oxide ErFeMnO5显示文摘 | Mu(n)oz A Alonso J A | 2005 | Phys Rev B2005，72，18： | 1 |
| 11 | Recent advances in two-phase partitioning bioreactors for the treatment of volatile organic compounds显示文摘 | Mu(n)oz R Daugulis A J Hernández M | 2012 | Biotechnol Adv2012，30，6： | 1 |
| 12 | A generalized single - channel method for retrieving land surface temperature from remote sensing data 显示文摘 | JIMENEZ - MU OZ J C SOBRINO J A | 2003 | Journal of Geophysical Research2003，108，： | 1 |
| 13 | Rheological aspects of the rejuvenation of aged bitumen显示文摘 | Ramón Romera Anton Santamaría Juan José Pe?a Maria Eugenia Mu?oz Marisol Barral Esteban García Victorio Ja?ez | 2006 | Rheologica Acta2006，，4： | 1 |
| 14 | Meningeal carcinomatosis in a dog:magnetic resonance imaging features and pathological correlation显示文摘 | Mateo I Lorenzo V Mu(n)oz A | | 0，，： | 1 |
| 15 | Changes in organic matter and residual effect of amendment with two-phase olive-mill waste on degraded agricultural soils显示文摘 | Antonio López-Pi?eiro Sergio Murillo Carla Barreto Ana Mu?oz José M. Rato Angel Albarrán Arturo García | 2007 | Science of the Total Environment2007，，1： | 1 |
| 16 | Genetic Polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) Genes Associated With Pathological Characteristics of Prostate Cancer in the Ecuadorian Population显示文摘 | Andrés López-Cortés Gabriela Jaramillo-Koupermann María J. Mu?oz Alejandro Cabrera Carolina Echeverría Felipe Rosales Nicolás Vivar César Paz-y-Mi?o | 2013 | The American Journal of the Medical Sciences2013，，： | 1 |
| 17 | Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls显示文摘 | JARAMILLO P C MUOZ M A LANAS M C | 2006 | Clin Chim Acta2006，371，12： | 1 |
| 18 | Effect of bur roughness on bond to sclerotic dentin with self-etch adhesive systems显示文摘 | Luque-Martinez IV Mena-Serrano A Mu(n)oz MA | | 0，，01： | 1 |
| 19 | Forage biomass of 22 shrub species from Monfragae Natural Park(SW Spain)assessed by log- log regression models显示文摘 | Paton D u? ez J Bao D Mu? oz A | 2002 | Journal of Arid Enviroments2002，，52： | 1 |
| 20 | Anti-inflammatory effects of resveratrol,curcumin and simvastatin in acute small intestinal inflammation显示文摘 | Beresw ill S Muoz M Fischer A | 2010 | PLoS One2010，5，15： | 1 |
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