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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 3 | Multilocular cystic renal cell carcinoma显示文摘 | Murad T Komaiko W Oyasu R | 1991 | Am J Clin Pathol1991，95，5： | 1 |
| 4 | Comparative effectiveness for survival and renal function of partial and radical nephrectomy for localized renal tumors:A systematic review and metaanalysis显示文摘 | KIM S P MURAD M H THOMPSON R H | 2012 | J Urol2012，，： | 1 |
| 5 | Associated factors affecting the successful pregnancy rate of intrauterine insemi- nation at International Islamic University Malaysia Fertility Centre显示文摘 | Azantee YW Murad ZA Roszaman R | 2011 | Med J Malaysia2011，66，3： | 1 |
| 6 | Phase Ⅱ trial of the combination of paclitaxel and 5-fluorouracil in the treatment of advanced gastric cancer:a novel,safe,and effective regimen显示文摘 | Murad A M Petroianu A Guimaraes R C | 1999 | Am J Clin Oncol1999，22，6： | 1 |
| 7 | Factors controlling groundwater quality in Eastern United Arab Emirates:A chemical and isotopic approach显示文摘 | Murad A A Krishnamurthy R V | 2004 | Journal of Hydrology2004，286，14： | 1 |
| 8 | Associated factors affecting the successful pregnancy rate of intrauterine insemination at International Islamic University Malaysia (IIUM) Fertility Cen- tre 显示文摘 | Azantee YW Murad ZA Roszaman R | 2011 | Med J Malaysia2011，66，3： | 1 |
| 9 | Cigarette smoke activates guanylate cyclase and increases guanosine 3′, 5′-monophosphate in tissues 显示文摘 | ARNOLD W P ALDRED R MURAD F | 1977 | Science1977，198，4320： | 1 |
| 10 | Accuracy of diagnostic tests fbr Cushing's syndrome:a systematic review and metaanalyses 显示文摘 | Elamin MB Murad MH Mullan R | 2008 | Joural of clinical Endocrinology & Metabolism2008，93，5： | 1 |
| 11 | Agonist-induced endothelium-dependent re- laxation in rat thoracic aorta may be mediated through cGMP显示文摘 | Rapoport R M Murad F | 1983 | Circ Res1983，52，3： | 1 |
| 12 | Multilocular cystic renal carcinoma显示文摘 | Murad T Komaiko W Oyasu R | 1991 | Am J Clin Pathol1991，95，5： | 1 |
| 13 | Comparative effectiveness for survival and renal function of partial and radical nephrectomy for localized renal tumors:a systematic review and meta-analysis显示文摘 | Kim S P Murad M H Thompson R H | 2012 | Journal of Urology2012，188，1： | 1 |
| 14 | Identification of a cowpea gamma-thionin with bactericidal activity显示文摘 | Franco O Murad A M Leite J R | 2006 | FEBS J2006，273，15： | 1 |
| 15 | A chemical method for the preparation of thin films of CdO and ZnO 显示文摘 | BENRAMDANE N MURAD W A MISHO R H | 1997 | Mater Chem Phys1997，48，11： | 1 |
| 16 | The effect of left subclavian artery coverage on morbidity and mortality in patients undergoing endovascular thoracic aortic interventions:A systematic review and meta-analysis显示文摘 | Rizvi A Z Murad M H Fairman R M | | 0，，： | 1 |
| 17 | How to teach evidence- based medicine to teachers: reflections from a workshop experience 显示文摘 | Murad MH Montori VM Kunz R | 2009 | J Eval Clin Pract2009，15，6： | 1 |
| 18 | Multilucular cystic renal cell carcinoma显示文摘 | Murad T komaiko W Oyasu R | 1991 | Am J Clin Pathol1991，95，5： | 1 |
| 19 | Accuracy of diagnostic tests for Cushing syndrome:a systematic review and meta-analyses显示文摘 | Elamin MB Murad MH Mullan R | | 0，，05： | 1 |
| 20 | Multilocular cystic renal carcinoma显示文摘 | Murad T Komaiko W Oyasu R | 1991 | Am J Clin Pathol1991，95，5： | 1 |
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