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| 1 | Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy显示文摘Molecular advances support the existence of an alternative pathway of colorectal carcinogenesis that is based on the hypermethylation of specific DNA regions that silences tumor suppressor genes. This alternative pathway has been called the serrated pathway due to the serrated appearance of tumors in histological analysis. New classifications for colorectal cancer(CRC) were proposed recently based on genetic profiles that show four types of molecular alterations: BRAF gene mutations, KRAS gene mutations, microsatellite instability, and hypermethylation of Cp G islands. This review summarizes what is known about the serrated pathway of CRC, including CRC molecular and clinical features, prognosis, and response to chemotherapy. | Oscar Murcia Miriam Juárez Eva Hernández-Illán Cecilia Egoavil Mar Giner-Calabuig María Rodríguez-Soler Rodrigo Jover | 2016 | World Journal of Gastroenterology2016，22，13： | 18 |
| 2 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)显示文摘暴露于ΣMWPm与任何胎儿大小或胎儿发育结局(见补充材料,表8)及所评估的出生结局(表2及补充材料表S7)都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性(-4.88%;95%CI:-8.36,-1.36),且与EFW增长减低也有显著相关性(-4.32%;95%CI:-8.33,-0.27)(图3及补充材料表S8)。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，9： | 3 |
| 4 | New insights into the molecular pathophysiology of polycystic kidney disease 显示文摘 | Murcia NS Sweeney WEJ Avner ED | 1999 | Kidney Int1999，55，4： | 2 |
| 5 | Long-term survival expectancy after liver transplantation in children显示文摘 | Migliazza L Santamaria L Murcia J | 2000 | J Pediatr Surg2000，35，1： | 1 |
| 6 | Peers' Influence On Exer- cise Enjoyment:A Self-determination Theory Approach 显示文摘 | Juan Antonio Moreno Murcia Maria Lopez de San Romfn Celestina Martinez Galindo Nestor Alonso David Gonzalez-Cutre | 2008 | Journal of Sports and Medicine2008，，1： | 1 |
| 7 | Grammar pedagogy in second and foreign language teaching显示文摘 | Celce -Murcia M | | 0，，03： | 1 |
| 8 | Assessment ofTREM2 rs75932628 association with Alzheimer's disease in apopulation -based sample : the cache county study 显示文摘 | Gonzalez Murcia JD Schmutz C Munger C | 2013 | NeurobiolAging2013，34，12： | 1 |
| 9 | Requirement of poly(ADP-ribose)polymerase in recovery from DNA damage in mice and cells显示文摘 | Murcia JM Niedergang C Trucco C | 2006 | Pro Nat Acad Sci2006，103，4： | 1 |
| 10 | Color flow Doppler characterization of foeal hepatic lesions显示文摘 | Nino - Murcia M Ralls PW Jeffrey Jr RB | 1992 | Am J Roentgenol1992，159，： | 1 |
| 11 | MDCT in pancreatic adenocarcinoma: prediction of vascular invasion and respectability using a mutiphase technique with curved planar reformation 显示文摘 | Vargas R Nino- Murcia M Trueblood W | 2004 | AJR2004，182，2： | 1 |
| 12 | Structure and function of poly ( ADP-rihose) polymerase 显示文摘 | de Murcia G Schreiber V Molinete M | 1994 | Mol Cell Biochem1994，138，12： | 1 |
| 13 | Facilesonochemical synthesis of highly luminescent ZnS-shelled CdSe quantum dots显示文摘 | Murcia M J Shaw D L Woodruff H | 2006 | Chemistry of materi-als2006，18，9： | 1 |
| 14 | Assessment of quality as perceived by users of an outpatient pharmaceutical care unit显示文摘 | ANTON T R MURCIA L A BORRAS B J | 2006 | Farm Hosp2006，30，2： | 1 |
| 15 | A KrCl exciplex flow-through photoreactor for degrading 4-chlorophenol: Experimental and modelling 显示文摘 | Gomez M Murcia M D Gomez J L | 2012 | Applied Catalysis B: Environmental(S0926-3373)2012，，： | 1 |
| 16 | Analysis of tantalum implants used for avascular necrosis of the femoral head:a review of five retrieved specimens显示文摘 | Fernández-Fairen M Murcia A Iglesias R | 2012 | J Appl Biomater Funct Mater2012，10，1： | 1 |
| 17 | Imaging the patient with right upper quadrant pain显示文摘 | Nino Murcia M Jeffrey RB Jr | 2001 | Semin Roentgenol2001，36，2： | 1 |
| 18 | Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization显示文摘 | Cano D A Murcia N S Pazour G J | 2004 | Development2004，131，14： | 1 |
| 19 | Spent mushroom substrates as component of growing media for ger- mination and growth of horticultural plants 显示文摘 | MEDINA E PAREDES C PEREZ~MURCIA M D | 2009 | Bioresource Technology2009，100，18： | 1 |
| 20 | The transdominant en- dogenous retrovirus enJS56A1 associates with and blocks intracellu- lar trafficking of Jaagsiekte sheep retrovirus Gag 显示文摘 | MURCIA P R ARNAUD F PALMARINI M | 2007 | J Virol2007，81，4： | 1 |
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