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| 1 | Quantitative analysis using ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal cancer,liver metastasis of colorectal cancer and hepatocellular carcinoma显示文摘TO THE EDITOR Angiogenesis consists of the sprouting of capillaries from pre-existing vessels . It is well-known that tumor growth is angiogenesis-dependent. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) stimulated vascular endothelial cell proliferation and are involved in the neoplastic angiogenesis of several types of tumors including those of the intestinal tract.Authors usually investigated VEGF and bFGF protein expressions using immunohistochemistry or Western blotting and VEGF and bFGF transcripts using reverse transcriptase polymerase chain reaction (RT-PCR). We recently reported in a previous issue of the World Journal of Gastroenterology that cirrhotic liver tissue levels of these two | Muriel Mathonnet Bernard Descottes Denis Valleix Francois Labrousse Véronique Truffinet Yves Denizot | 2006 | World Journal of Gastroenterology2006，12，23： | 27 |
| 2 | Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways显示文摘AIM To study the molecular mechanisms involved in the hepatoprotective effects of naringenin(NAR)on carbon tetrachloride(CCl4)-induced liver fibrosis.METHODS Thirty-two male Wistar rats(120-150 g)were randomly divided into four groups:(1)a control group(n=8)that received 0.7%carboxy methyl-cellulose(NAR vehicle)1 m L/daily p.o.;(2)a CCl4 group(n=8)that received 400 mg of CCl4/kg body weight i.p.3 times a week for 8 wk;(3)a CCl4+NAR(n=8)group that received 400 mg of CCl4/kg body weight i.p.3times a week for 8 wk and 100 mg of NAR/kg body weight daily for 8 wk p.o.;and(4)an NAR group(n=8)that received 100 mg of NAR/kg body weight daily for 8 wk p.o.After the experimental period,animals were sacrificed under ketamine and xylazine anesthesia.Liver damage markers such as alanine aminotransferase(ALT),alkaline phosphatase(AP),γ-glutamyl transpeptidase(γ-GTP),reduced glutathione(GSH),glycogen content,lipid peroxidation(LPO)and collagen content were measured.The enzymatic activity of glutathione peroxidase(GPx)was assessed.Liver histopathology was performed utilizing Masson’s trichrome and hematoxylin-eosin stains.Zymography assays for MMP-9 and MMP-2 were carried out.Hepatic TGF-β,α-SMA,CTGF,Col-I,MMP-13,NF-κB,IL-1,IL-10,Smad7,Smad3,p Smad3 and p JNK proteins were detected via western blot.RESULTS NAR administration prevented increases in ALT,AP,γ-GTP,and GPx enzymatic activity;depletion of GSH and glycogen;and increases in LPO and collagen produced by chronic CCl4 intoxication(P<0.05).Liver histopathology showed a decrease in collagen deposition when rats received NAR in addition to CCl4.Although zymography assays showed that CCl4 produced an increase in MMP-9 and MMP-2gelatinase activity;interestingly,NAR administration was associated with normal MMP-9 and MMP-2 activity(P<0.05).The anti-inflammatory,antinecrotic and antifibrotic effects of NAR may be attributed to its ability to prevent NF-κB activation and the subsequent production of IL-1 and IL-10(P<0.05).NAR completely prevented the increase in TGF-β,α-SMA,CTGF,Col-1,and MMP-13 proteins compared with the CCl4-treated group(P<0.05).NAR prevented Smad3phosphorylation in the linker region by JNK since this flavonoid blocked this kinase(P<0.05).CONCLUSION NAR prevents CCl4 induced liver inflammation,necrosis and fibrosis,due to its antioxidant capacity as a free radical inhibitor and by inhibiting the NF-κB,TGF-β-Smad3 and JNK-Smad3 pathways. | Erika Hernández-Aquino Natanael Zarco Sael Casas-Grajales Erika Ramos-Tovar Rosa E Flores-Beltrán Jonathan Arauz Mineko Shibayama Liliana Favari Víctor Tsutsumi José Segovia Pablo Muriel | 2017 | World Journal of Gastroenterology2017，23，24： | 10 |
| 3 | Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma显示文摘瞄准:激活血小板的因素(PAF ) 是一个支持 inflammatory 和 angiogenic 类脂化合物调停人。这里,我们试图调查 PAF 的层次, lyso-PAF ( PAF 先锋),磷脂酶 A ( 2 )( PLA ( 2 ),产生 lyso-PAF 的酶的活动), acetylhydrolase 活动(啊哈, PAF 降级的酶)并且在硬变肝和肝细胞癌( HCC )的 PAF 受体( PAF-R )抄本。方法:有 HCC 的 29 个病人在这研究被注册。肝硬化在十四个病人是在场的,七没有肝疾病。织物 PAF 层次被血小板聚集试金调查。Lyso-PAF 在它的化学乙酰化作用以后被估计进 PAF。啊哈被降级决定[(3 ) H ]-PAF。PLA (2 ) 层次被 EIA 估计。PAF-R 抄本用 RT-PCR 被调查。结果:PAF 和 PAF-R 抄本的提高的数量(白血球类型) 1 作为与非肝脏硬化症的相比在肝脏硬化症的纸巾被发现。PAF 和 PAF-R 抄本的更高的数量(织物类型) 1 和 2 作为与非肿瘤纸巾相比在 HCC 纸巾被发现。PLA (2 ) , lyso-PAF 和啊哈层次没在肝脏硬化症的纸巾和 HCC 被改变。结论:当 PAF 的角色在肝生理学当前是未知的时,这研究在在 HCC 期间在硬变肝并且在 angiogenic 反应发现的煽动性的网络建议它的潜在的参与。 | Muriel Mathonnet Bernard Descottes Denis Valleix Véronique Truffinet Franois Labrousse Yves Denizot | 2006 | World Journal of Gastroenterology2006，12，17： | 7 |
| 4 | Meta-DiSc: a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 5 | Meta-DiSc:a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 6 | Meta-DiSc : a software for Meta- analysis of test accuracy data 显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 7 | Meta-DiSc:a softwarefor meta-analysis of test accuracy data 显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med ResMethodol2006，6，： | 1 |
| 8 | Meta-Disc:a software for meta-analysis of test accuracy data 显示文摘 | Zarnora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，1： | 1 |
| 9 | Meta-DiSc: asoftware for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 10 | Evidence for interfacial uptake in hexadecane degradation by Rhodococcusequi:the importance of cell flocculation显示文摘 | Murielle B N Blanchet D Bardin V | 2001 | Microbiology2001，147，： | 1 |
| 11 | Meta-DiSc : a software for me- ta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 12 | Thalidomide ameliorates carbon tetrachlofide induced cirrhosis in the rat 显示文摘 | Muriel P Femgmdez Martinez E Alvarez V | 2003 | Eur J Gastroenteml Hepatol2003，15，9： | 1 |
| 13 | Meta-DiSc:a software formeta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 14 | Effects of s2adeno2syl212methionine and interfer on 2alpha2bon liver damage induced by bile ductligation in rats 显示文摘 | Muriel P Gastro V | 1998 | J Appl Toxicol1998，18，2： | 1 |
| 15 | Meta-DiSc:a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，，6： | 1 |
| 16 | Meta-DiSc:a software for metaanalysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 17 | Proteomic analysis of dendritic cell-derived exosomcs: a secreted subcellular compartment distinct from apoptotic vesicles显示文摘 | Clotilde T Muriel B Philippe V | 2001 | J lmmunol2001，166，12： | 1 |
| 18 | Haemophilus parasuis-novel proteins-hopes for vaccine显示文摘 | Mcvicker J Tabatabai L Muriel V S | 2005 | Respiratory Diseases of Livestock2005，10，： | 1 |
| 19 | Hatmophilus parasuis-novel proteins-hopes for vaccine显示文摘 | Mcvicker J Tabatabal L Muriel V S | 2005 | Respiratory diseases of livestock2005，10，： | 1 |
| 20 | Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease 显示文摘 | Muriel MP Bernard V Levey AI | 1999 | Ann Neurol1999，46，1： | 1 |
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