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| 1 | Role of Nrf2 in chronic liver disease显示文摘Nuclear erythroid 2-related factor 2(Nrf2) is a central regulator of antioxidative response elements-mediated gene expression. It has a significant role in adaptive responses to oxidative stress by interacting with the antioxidant response element, which induces the expression of a variety of downstream targets aimed at cytoprotection. Previous studies suggested oxidative stress and associated damage could represent a common link between different forms of diseases. Oxidative stress has been implicated in various liver diseases, including viral hepatitis, nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease and drug-induced liver injury. Nrf2 activation is initiated by oxidative or electrophilic stress, and aids in the detoxification and elimination of potentially harmful exogenous chemicals and their metabolites. The expression of Nrf2 has been observed throughout human tissue, with high expression in detoxification organs, especially the liver. Thus, Nrf2 may serve as a major regulator of several cellular defense associated pathways by which hepatic cells combat oxidative stress. We review the relevant literature concerning the crucial role of Nrf2 and its signaling pathways against oxidative stress to protect hepatic cell from oxidative damage during development of common chronic liver diseases. We also review the use of Nrf2 as a therapeutic target to prevent and treat liver diseases. | Wei Tang Yong-Fang Jiang Murugavel Ponnusamy Mamadou Diallo | 2014 | World Journal of Gastroenterology2014，20，36： | 14 |
| 2 | Coinfection of hepatitis B and hepatitis C virus in HIV-infectedpatients in south India显示文摘AIM: To screen for the co-infection of hepatitis B (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected patients in southern India. METHODS: Five hundred consecutive HIV infected patients were screened for Hepatitis B Virus (HBsAg and HBV-DNA) and Hepatitis C virus (anti-HCV and HCV-RNA) using commercially available ELISA kits; HBsAg, HBeAg/ anti-HBe (Biorad laboratories, USA) and anti-HCV (Murex Diagnostics, UK). The HBV-DNA PCR was performed to detect the surface antigen region (pre S-S). HCV-RNA was detected by RT-PCR for the detection of the constant 5' putative non-coding region of HCV. RESULTS: HBV co-infection was detected in 45/500 (9%) patients and HCV co-infection in 11/500 (2.2%) subjects. Among the 45 co-infected patients only 40 patients could be studied, where the detection rates of HBe was 55% (22/40), antiHBe was 45% (18/40) and HBV-DNA was 56% (23/40). Among 11 HCV co-infected subjects, 6 (54.5%) were anti-HCV and HCV RNA positive, while 3 (27.2%) were positive for anti-HCV alone and 2 (18%) were positive for HCV RNA alone. CONCLUSION: Since the principal routes for HIV transmission are similar to that followed by the hepatotropic viruses, as a consequence, infections with HBV and HCV are expected in HIV infected patients. Therefore, it would be advisable to screen for these viruses in all the HIV infected individuals and their sexual partners at the earliest. | Shanmugam Saravanan Vijayakumar Velu Nagalingeswaran Kumarasamy Subhadra Nandakumar Kailapuri Gangatharan Murugavel Pachamuthu Balakrishnan Solomon Suniti Sadras Panchatcharam Thyagarajan | 2007 | World Journal of Gastroenterology2007，13，37： | 6 |
| 3 | Hetero-and metallasiloxanes derived from silanediols, disilanols, silanetriols, and trisilanols显示文摘 | MURUGAVEL R VOIGT A | 1996 | Chem Rev1996，96，： | 1 |
| 4 | Metal complexes of organophosphate esters and open-framework metal phosphates:synthesis,structure,transformations,and applications显示文摘 | Murugavel R Choudhury A Walawalkar M G | 2008 | Chemical Reviews2008，108，9： | 1 |
| 5 | Microwave Assisted Solid-state Synthesis of Functional Organotin Carboxylates from StericallyEncumbered 3,5-Di-tert-butylsalicylic Acid显示文摘 | Murugavel R Gogoi N | 2008 | Organomet Chem2008，693，： | 1 |
| 6 | Correlation of hepatitis B and C viral markers with aflatoxin and AFP in Hepatocellular carcinoma cases from Tamil Nadu显示文摘 | MURUGAVEL K G MOHAN K V PRAMOD N P | 1999 | Indian J Gastroenterol1999，18，： | 1 |
| 7 | Progresses in inclined type solar stills 显示文摘 | Kalidasa K Murugavel Anburaj P SamuelHanson R | 2013 | Renewable and Sustainable Energy Reviews2013，20，： | 1 |
| 8 | The single-phase multiferroic oxides:from bulk to thin film显示文摘 | Prellier W Singh M P Murugavel P | 2005 | J Phys:Condense Matter2005，17，48： | 1 |
| 9 | Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats 显示文摘 | Pail L Murugavel P | 2004 | J Appl Toxicol2004，24，1： | 1 |
| 10 | Ethnic variation in certain hematological and bio-chemical reference intervals in a south Indian healthy adult population 显示文摘 | Sundaram M Mohanakrishnan J Murugavel KG | 2008 | Eur J Intern Med2008，19，： | 1 |
| 11 | Ethnic variation in certain hematological and biochemical reference intervals in a south Indian healthy adult population显示文摘 | Sundaram M Mohanakrishnan J Murugavel KG | 2008 | Eur J Intern Med2008，19，1： | 1 |
| 12 | Bacterial vaginosis in fe- male sex workers in chennai, india 显示文摘 | Urea S Balakrishnan P Murugavel KG | 2005 | Sexual Health2005，2，4： | 1 |
| 13 | Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats显示文摘 | Pari L Murugavel P | 2004 | J Appl Toxicol2004，24，1： | 1 |
| 14 | Physicalproperties of multiferroic hexagonal HoMn03 thin films显示文摘 | Murugavel P Lee J H Lee D | 2007 | Applied Physics Letters2007，90，14： | 1 |
| 15 | Alpha-feto- protein as a tumor marker in hepatoeellular carcinoma:in- vestigations in south Indian subjects with hepatotropic vi- rus and aflatoxin etiologies显示文摘 | Murugavel KG Mathews S Jayanthi V | 2010 | Int J Infect Dis2010，12，6： | 1 |
| 16 | Titanosilicates: Recent devel- opments in synthesis and use as oxidation catalysts显示文摘 | Murugavel R Roesky H W | 1997 | An-gewandte Chemie International Edition1997，36，5： | 1 |
| 17 | Petri net modeling of gate and interconnect delays for power estimation显示文摘 | MURUGAVEL A K RANGANATHAN N | 2003 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2003，11，5： | 1 |
| 18 | The single-phase multiferroic oxides: From bulk to thin film显示文摘 | Prellier W Singh M P Murugavel P | 2005 | Phys Condens Matter2005，17，： | 1 |
| 19 | Cam- phorsulfonic acid catalysed facile tandem double Fried- lander annulation protocol for the synthesis of phenoxylinked bisquinoline derivatives and discovery of antitu- bereular agents 显示文摘 | Paul N Murugavel M Muthusubramanian S | 2012 | Bioorg Med Chem Lett2012，22，4： | 1 |
| 20 | Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats 显示文摘 | PARI L MURUGAVEL P | 2004 | J Appl Toxicol2004，24，1： | 1 |
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