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| 1 | Endoscopic stenting for inoperable malignant biliary obstruction: A systematic review and meta-analysis显示文摘AIM: To analyze through meta-analyses the benefits of two types of stents in the inoperable malignant biliary obstruction.METHODS: A systematic review of randomized clinical trials(RCT) was conducted, with the last update on March 2015, using EMBASE, CINAHL(EBSCO), MEDLINE, LILACS/CENTRAL(BVS), SCOPUS, CAPES(Brazil), and gray literature. Information of the selected studies was extracted in sight of six outcomes: primarily regarding dysfunction, complication and reintervention rates; and secondarily costs, survival, and patency time. The data about characteristics of trial participants, inclusion and exclusion criteria and types of stents were also extracted. The bias was mainly assessed through the JADAD scale. This meta-analysis was registered in the PROSPERO database by the number CRD42014015078. The analysis of the absolute risk of the outcomes was performed using the software Rev Man, by computing risk differences(RD) of dichotomous variables and mean differences(MD) of continuous variables. Data on RD and MD for each primary outcome were calculated using the MantelHaenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%, a subsequent assay was done and other findings were compiled. Student's t-test was used for the comparison of weighted arithmetic means regarding secondary outcomes.RESULTS: Initial searching identified 3660 studies; 3539 were excluded through title, repetition, and/or abstract, while 121 studies were fully assessed and were excluded mainly because they did not compare self-expanding metal stents(SEMS) and plastic stents(PS), leading to thirteen RCT selected, with 13 articles and 1133 subjects meta-analyzed. The mean age was 69.5 years old, that were affected mostly by bile duct(proximal) and pancreatic tumors(distal). The preferred SEMS diameter used was the 10 mm(30 Fr) and the preferred PS diameter used was 10 Fr. In the metaanalysis, SEMS had lower overall stent dysfunction compared to PS(21.6% vs 46.8%, P < 0.00001) and fewer re-interventions(21.6% vs 56.6%, P < 0.00001), with no difference in complications(13.7% vs 15.9%, P = 0.16). In the secondary analysis, the mean survival rate was higher in the SEMS group(182 d vs 150 d, P < 0.0001), with a higher patency period(250 d vs 124 d, P < 0.0001) and a lower cost per patient(4193.98 vs 4728.65 Euros, P < 0.0985).CONCLUSION: SEMS are associated with lower stent dysfunction, lower re-intervention rates, better survival, and higher patency time. Complications and costs showed no difference. | Leonardo Zorrón Pu Eduardo Guimaraes Hourneaux de Moura Wanderley Marques Bernardo Felipe Iankelevich Baracat Ernesto Quaresma Mendonca AndréKondo Gustavo Oliveira Luz Carlos Kiyoshi Furuya Júnior Everson Luiz de Almeida Artifon | 2015 | World Journal of Gastroenterology2015，21，47： | 10 |
| 2 | Human β-defensin-3 induction in H pylori-infected gastric mucosal tissues显示文摘AIM: To examine human β-defensin-3 (hBD-3) expression in inflamed gastric mucosal tissues or MKN45 gastric cancer cells with or without H pylori infection for better understanding the innate immune response to H pylori. METHODS: We used reverse transcription-polymerase chain reactions and immunohistochemistry to examine hBD-3 expression in inflamed gastric mucosal tissues or MKN45 gastric cancer cells with or without H pylori. Effects of hBD-3 against H pylori were also evaluated. RESULTS: The mean mRNA expression of hBD-3 in H pylori -positive specimens was significantly higher than that in H pylori-negative specimens (P = 0.0002, Mann-Whitney). In addition, unlike uninfected samples, 8 of 15 (53.33%) infected mucosal samples expressed hBD-3 protein. H pylori dose-dependently induced mRNA expression of hBD-3 in MKN45 cells, an effect inhibited by adding anti-toll-like receptor (TLR)-4 antibody. HBD-3 protein completely inhibited H pylori growth. CONCLUSION: Our results suggest that like hBD-2, hBD-3 may be involved in the pathophysiology of H pylori-induced gastritis. | K Kawauchi A Yagihashi N Tsuji N Uehara D Furuya D Kobayashi N Watanabe | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 3 | Selection of an internal control gene for quantitation of mRNA in colonic tissues显示文摘 | Tsuji N Kamagata C Furuya M et a1 | 2002 | Anticancer Res2002，22，6： | 1 |
| 4 | The evolutionarily eonserved domain of Beclin 1 is required for Vps34 binding,autophagy and tumor suppressor function显示文摘 | Furuya N Yu J Byfield M | | 0，，01： | 1 |
| 5 | Selection of an internal control gene for quantitation of mRNA in colonic tissues显示文摘 | Tsuji N Kamagata C Furuya M | 2002 | Anticancer Res2002，22，6： | 1 |
| 6 | In vitro and in vivo anti- bacterial activities of L- 084, a novel oral carbapenem, against causative organisms of respiratory tract infections 显示文摘 | Miyazaki S Hosoyama T Furuya N | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 7 | The MAP1-LC3 conjugation system is involved in lipid droplet formation显示文摘 | Shibata M Yoshimura K Furuya N | 2009 | Biochemical and Biophysical Research Communications2009，382，2： | 1 |
| 8 | The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function 显示文摘 | Furuya N Yu J Byfield M | 2005 | Autophagy2005，1，： | 1 |
| 9 | The MAP1-LC3 conju- gation system is involved in lipid droplet formation 显示文摘 | Shibata M Yoshimura K Furuya N | 2009 | Biochem Biophys Res Commun2009，382，2： | 1 |
| 10 | Single minimum incisionendoscopic radical nephrectomy for renal tumors with preoperative virtual navigation using 3D-CT volume rendering 显示文摘 | Kamai T Furuya N Kambara T | 2010 | BMC Urol2010，10，： | 1 |
| 11 | Pathogenesis and phylogenetic analyses of canine distemper virus strain 007Lm,a new isolate in dogs显示文摘 | LAN N T YAMAGUCHI R FURUYA Y | 2005 | Vet Microbiol2005，110，34： | 1 |
| 12 | Incidence and characteristics of peroperative pulmonary thromboembilism in Japan in 2003显示文摘 | Kuroiwa M Furuya H Seo N | 2005 | Masui2005，54，7： | 1 |
| 13 | Magnetic resonance imaging is accurate to detect bleeding in the seminal vesicles in patients with hemospermia显示文摘 | Furuya S Furuya R Masumori N | 2008 | Urology2008，72，4： | 1 |
| 14 | Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene显示文摘 | Qu X Yu J Bhagat G Furuya N | | 0，，12： | 1 |
| 15 | 显示文摘 | Nishimoto A Agehara K Furuya N | 1999 | Macromolecules1999，32，： | 1 |
| 16 | Cell therapy with adipose tissue-derived stem/stromal cells for elastase- induced pulmonary emphysema in rats显示文摘 | Furuya N Takenaga M Ohta Y | 2012 | Regen Med2012，7，4： | 1 |
| 17 | Progressive de- velopment of the osteoblast phenotype during differentiation of os- teoprogenitor cells derived from fetal rat calvaria: model for in vitro bone formation 显示文摘 | YAMAMOTO N FURUYA K HANADA K | 2002 | Biol Pharm Bull2002，25，4： | 1 |
| 18 | Identification of the endophytic bacterial isolates and their in vitro and in vivo antago- nism against Ralstonia solanacearum 显示文摘 | Long H H Furuya N Yamamoto I | 2004 | Journal of the Faculty of Agriculture2004，49，2： | 1 |
| 19 | Applications of magnesium alloys for aerospace structure systems显示文摘 | FURUYA H KOGISO N | 2001 | Mater Sci Forum2001，，： | 1 |
| 20 | Application of the gas diffusion electrode of high performance to high- speed zinc electrowinning cells 显示文摘 | Furuya N Motoo S | 1984 | J Appl Electrochem1984，79，12： | 1 |
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