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| 1 | Human thrombin for the treatment of gastric and ectopic varices显示文摘AIM:To evaluate the efficacy of human thrombin in the treatment of bleeding gastric and ectopic varices.METHODS:Retrospective observational study in a Tertiary Referral Centre.Between January 1999-October 2005,we identified 37 patients who were endoscopically treated with human thrombin injection therapy for bleeding gastric and ectopic varices.Patient details including age,gender and aetiology of liver disease/segmental portal hypertension were documented.The thrombin was obtained from the Scottish National Blood Transfusion Service and prepared to give a solution of 250 IU/mL which was injected via a standard injection needle.All patient case notes were reviewed and the total dose of thrombin given along with the number of endoscopy sessions was recorded.Initial haemostasis rates,rebleeding rates and mortality were catalogued along with the incidence of any immediate complications which could be attributable to the thrombin therapy.The duration of follow up was also listed.The study was conducted according to the United Kingdom research ethics guidelines.RESULTS:Thirty-seven patients were included.33 patients(89%) had thrombin(250 U/mL) for gastric varices,2(5.4%) for duodenal varices,1 for rectal varices and 1 for gastric and rectal varices.(1) Gastric varices,an average of 15.2 mL of thrombin was used per patient.Re-bleeding occurred in 4 patients(10.8%),managed in 2 by a transjugular intrahepatic portosystemic shunt(TIPSS)(one unsuccessfully who died) and in other 2 by a distal splenorenal shunt;(2) Duodenal varices(or type 2 isolated gastric varices),an average of 12.5 mL was used per patient over 2-3 endoscopy sessions.Re-bleeding occurred in one patient,which was treated by TIPSS;and(3) Rectal varices,an average of 18.3 mL was used per patient over 3 endoscopy sessions.No re-bleeding occurred in this group.CONCLUSION:Human thrombin is a safe,easy to use and effective therapeutic option to control haemorrhage from gastric and ectopic varices. | Norma C McAvoy John N Plevris Peter C Hayes | 2012 | World Journal of Gastroenterology2012，18，41： | 11 |
| 2 | An integrated system for planning, navigation and robotic assistance for skull base surgery显示文摘BACKGROUND: We developed an image-guided robot system to provide mechanical assistance for skull base drilling,which is performed to gain access for some neurosurgical interventions, such as tumour resection. The motivation for introduc-ing this robot was to improve safety by preventing the surgeon from accidentally damaging critical neurovascular structures dur- | Baird C Jallo G Hayes K Nakajima N Hata N Kazanzides P | 2008 | 中国神经肿瘤杂志2008，6，3： | 6 |
| 3 | HIGH-ENERGY IONS PRODUCED IN EXPLOSIONS OF SUPERHEATED ATOMIC CLUSTERS显示文摘 | T Ditmire J W G Tisch E Springate M B Mason N Hay R A Smith J Marangos and M H R Hutchinson | | 0，，： | 4 |
| 4 | California Simulation of Evapotranspiration of Applied Water and Agricultural Energy Use in California显示文摘The California Simulation of Evapotranspiration of Applied Water (Cal-SIMETAW) model is a new tool developed by the California Department of Water Resources and the University of California, Davis to perform daily soil water balance and determine crop evapotranspiration (ET c ), evapotranspiration of applied water (ET aw ), and applied water (AW) for use in California water resources planning. ET aw is a seasonal estimate of the water needed to irrigate a crop assuming 100% irrigation efficiency. The model accounts for soils, crop coefficients, rooting depths, seepage, etc. that influence crop water balance. It provides spatial soil and climate information and it uses historical crop and land-use category information to provide seasonal water balance estimates by combinations of detailed analysis unit and county (DAU/County) over California. The result is a large data base of ET c and ET aw that will be used to update information in the new California Water Plan (CWP). The application uses the daily climate data, i.e., maximum (T x ) and minimum (T n ) temperature and precipitation (P cp ), which were derived from monthly USDA-NRCS PRISM data (PRISM Group 2011) and daily US National Climate Data Center (NCDC) climate station data to cover California on a 4 km×4 km change grid spacing. The application uses daily weather data to determine reference evapotranspiration (ET o ), using the Hargreaves-Samani (HS) equation (Hargreaves and Samani 1982, 1985). Because the HS equation is based on temperature only, ET o from the HS equation were compared with CIMIS ET o at the same locations using available CIMIS data to determine correction factors to estimate CIMIS ET o from the HS ET o to account for spatial climate differences. Cal-SIMETAW also employs near real-time reference evapotranspiration (ET o ) information from Spatial CIMIS, which is a model that combines weather station data and remote sensing to provide a grid of ET o information. A second database containing the available soil water holding capacity and soil depth information for all of California was also developed from the USDA-NRCS SSURGO database. The Cal-SIMETAW program also has the ability to generate daily weather data from monthly mean values for use in studying climate change scenarios and their possible impacts on water demand in the state. The key objective of this project is to improve the accuracy of water use estimates for the California Water Plan (CWP), which provides a comprehensive report on water supply, demand, and management in California. In this paper, we will discuss the model and how it determines ET aw for use in water resources planning. | Morteza N Orang Richard L Snyder Shu Geng Quinn J Hart Sara Sarreshteh Matthias Falk Dylan Beaudette Scott Hayes Simon Eching | 2013 | Journal of Integrative Agriculture2013，12，8： | 3 |
| 5 | Stem cell differentiation and human liver disease显示文摘Human stem cells are scalable cell populations capable of cellular differentiation.This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells.Such an approach has the potential to improve our understanding of human biology and treating disease.In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases.In recent years,eff icient hepatic differentiation from human stem cells has been achieved by several research groups including our own.In this review we provide an overview of the f ield and discuss the future potential and limitations of stem cell technology. | Wen-Li Zhou Claire N Medine Liang Zhu David C Hay | 2012 | World Journal of Gastroenterology2012，18，17： | 3 |
| 6 | Discharge Coefficient of Turbine Cooling Hole:A Review显示文摘 | Hay N Lampard D | 1998 | Trans of ASME1998，120，： | 2 |
| 7 | Primary graft dysfunction after liver transplantation: From pathogenesis to prevention显示文摘 | Khalid I Bzeizi Rajiv Jalan John N Plevris Peter C Hayes | 2003 | Liver Transpl2003，，2： | 2 |
| 8 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 9 | The network weather service:A distributed resource performance forecasting service for metacomputing显示文摘 | Wolski R Spring N Hayes J | 1999 | Journal of Future Generation Computing Systems1999，15，5： | 2 |
| 10 | Update of endoscopy in liver disease:More than just treating varices显示文摘The management of complications in liver disease is often complex and challenging.Endoscopy has undergone a period of rapid expansion with numerous novel and specialized endoscopic modalities that are of increasing value in the investigation and management of the patient with liver disease.In this review,relevant literature search and expert opinions have been used to provide a brief overview and update of the current endoscopic management of patients with liver disease and portal hypertension.The main areas covered are safety of endoscopy in patients with liver disease,the use of standard endoscopy for the treatment of varices and the role of new endoscopic modalities such as endoscopic ultrasound,esophageal capsule,argon plasma coagulation,spyglass and endomicroscopy in the investigation and treatment of liver-related gastrointestinal and biliary pathology.It is clear that the role of the endoscopy in liver disease is well beyond that of just treating varices.As the technology in endoscopy expands,so does the role of the endoscopist in liver disease. | Christoforos Krystallis Gail S Masterton Peter C Hayes John N Plevris | 2012 | World Journal of Gastroenterology2012，18，5： | 2 |
| 11 | Review article : the management of acute liver failure 显示文摘 | Plevris J N Schina M Hayes P C | 1998 | Aliment Pharmacol Ther1998，12，5： | 1 |
| 12 | Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus 显示文摘 | Kauma SW Huff TF Hayes N | 1999 | J Clin Endocrinol Metab1999，84，6： | 1 |
| 13 | Upstream and downstream of mTOR显示文摘 | Hay N Sonenberg N | 2004 | Gnens Dev2004，18，16： | 1 |
| 14 | Characterisation of protective surface films formed on molten magnesium protect-ed by Air/SF6 atmospheres显示文摘 | CASHION S P RICKETTS N J HAYES P C | 2002 | Journal of Light Metals2002，2，1： | 1 |
| 15 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 16 | The kinetics and mechanisms of the thermal degradation of poly (methyl methacrylate) studied by thermal analysis-Fourier transform infrared spectroscopy显示文摘 | Holland B J Hay J N | 2011 | Polymer2011，42，11： | 1 |
| 17 | Hijacking leueyl-tRNA synthetase for amino acid-dependent regulation of TORC1 显示文摘 | Segev N Hay N | 2012 | Mol Cell2012，46，： | 1 |
| 18 | Genome-wide association study of prostate cancer identifies a second risk locus at 8q24显示文摘 | Yeager M Orr N Hayes RB | 2007 | Nat Genet2007，39，： | 1 |
| 19 | The network weather service: a distributed resource performance forecasting service for meta computing显示文摘 | WOLSKI R SPRING N HAYES J | 1999 | Future Generation Computer Systems1999，15，10： | 1 |
| 20 | The mechanism of protection of molten magnesium by cover gas mixtures containing sulphur hexafluoride显示文摘 | CASHION S P RICKETTS N J HAYES P C | 2002 | Journal of Light Metals2002，2，1： | 1 |
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