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| 1 | Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions显示文摘AIM:To evaluate the utility of diffusion-weighted im-aging(DWI)in screening and differential diagnosis of benign and malignant focal hepatic lesions.METHODS:Magnetic resonance imaging(MRI)ex-aminations were performed using the Signa Excite Xl Twin Speed 1.5T system(GE Healthcare,Milwaukee,WI,USA).Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas(HCC),four cholangiocarcinomas,34 metastatic liver cancers,10 hemangiomas,and eight cysts] between April 2004 and August 2008 were retrospectively evaluated.Visu-alization of lesions,relative contrast ratio(RCR),and apparent diffusion coefficient(ADC)were compared between benign and malignant lesions on DWI.Su-perparamagnetic iron oxide(SPIO)was administered to 59 patients,and RCR was compared pre-and post-administration.RESULTS:DWI showed higher contrast between ma-lignant lesions(especially in multiple small metastatic cancers)and surrounding liver parenchyma than did contrast-enhanced computed tomography.ADCs(mean ± SD × 10-3 mm2/s)were signif icantly lower(P < 0.05)in malignant lesions(HCC:1.31 ± 0.28 and liver me-tastasis:1.11 ± 0.22)and were signifi cantly higher in benign lesions(hemangioma:1.84 ± 0.37 and cyst:2.61 ± 0.45)than in the surrounding hepatic tissues.RCR between malignant lesions and surrounding he-patic tissues signifi cantly improved after SPIO adminis-tration,but RCRs in benign lesions were not improved.CONCLUSION:DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for dif-ferential diagnosis. | Naoto Koike Akihiro Cho Katsuhiro Nasu Kazuhiko Seto Shigeyuki Nagaya Yuji Ohshima Nobuhiro Ohkohchi | 2009 | World Journal of Gastroenterology2009，15，46： | 38 |
| 2 | Current status, problems, and perspectives of non-alcoholic fatty liver disease research显示文摘Non-alcoholic fatty liver disease(NAFLD) is a major chronic liver disease that can lead to liver cirrhosis, liver cancer, and ultimately death. NAFLD is pathologically classified as non-alcoholic fatty liver(NAFL) or non-alcoholic steatohepatitis(NASH) based on the existence of ballooned hepatocytes,although the states have been known to transform into each other. Moreover,since the detection of ballooned hepatocytes may be difficult with limited biopsied specimens, its clinical significance needs reconsideration. Repeated liver biopsy to assess histological NAFLD activity for therapeutic response is also impractical, creating the need for body fluid biomarkers and less invasive imaging modalities. Recent longitudinal observational studies have emphasized the importance of advanced fibrosis as a determinant of NAFLD outcome. Thus,identifying predictors of fibrosis progression and developing better screening methods will enable clinicians to isolate high-risk NAFLD patients requiring early intensive intervention. Despite the considerable heterogeneity of NAFLD with regard to underlying disease, patient age, and fibrosis stage, several clinical trials are underway to develop a first-in-class drug. In this review, we summarize the present status and future direction of NAFLD/NASH research towards solving unmet medical needs. | Naoki Tanaka Takefumi Kimura Naoyuki Fujimori Tadanobu Nagaya Michiharu Komatsu Eiji Tanaka | 2019 | World Journal of Gastroenterology2019，25，2： | 29 |
| 3 | Impact of dendritic cell vaccines pulsed with Wilms’ tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers显示文摘 | Hidenori Takahashi Masato Okamoto Shigetaka Shimodaira Shun-ichi Tsujitani Masaki Nagaya Takefumi Ishidao Junji Kishimoto Yoshikazu Yonemitsu | 2012 | European Journal of Cancer2012，，： | 3 |
| 4 | Residual Displacement Response Spectrum显示文摘 | Kazuhiko Kawashima Gregory A. MacRae Jyun-ichi Hoshikuma Kazuhiro Nagaya | 1998 | Journal of Structural Engineering1998，，5： | 3 |
| 5 | Plasma Brain Natriuretic Peptide Levels Increase in Proportion to the Extent of Right Ventricular Dysfunction in Pulmonary Hypertension显示文摘 | Noritoshi Nagaya Toshio Nishikimi Yoshiaki Okano Masaaki Uematsu Toru Satoh Shingo Kyotani Sachio Kuribayashi Seiki Hamada Mikio Kakishita Norifumi Nakanishi Makoto Takamiya Takeyoshi Kunieda Hisayuki Matsuo Kenji Kangawa | 1998 | Journal of the American College of Cardiology1998，，1： | 2 |
| 6 | Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy: a multicenter analysis显示文摘 | Masanori Kobayashi Shigetaka Shimodaira Kazuhiro Nagai Masahiro Ogasawara Hidenori Takahashi Hirofumi Abe Mitsugu Tanii Masato Okamoto Sun-ichi Tsujitani Seiichi Yusa Takefumi Ishidao Junji Kishimoto Yuta Shibamoto Masaki Nagaya Yoshikazu Yonemitsu | 2014 | Cancer Immunology, Immunotherapy2014，，： | 2 |
| 7 | Hemodynamic,renal,and hormonal effects of adrenomedullin infusion with congestive heart failure显示文摘 | NAGAYA N SATOH T NISHIKIMI T | 2000 | Circulation2000，101，5： | 2 |
| 8 | Hemodynomic, renal and hormonal effects of adrenomedullin infusion in patients with congestive heart failure显示文摘 | Nagaya N Satch T Nishikimi T | 2000 | Circulation2000，101，5： | 2 |
| 9 | Development of an in-wheel drive with advanced dynamic-damper mechanism显示文摘 | Go Nagaya Yasumichi Wakao Akihiko Abe | 2003 | JSAE Review2003，，4： | 2 |
| 10 | Effects of ghrelin administration on left ventricular function,exercise capacity,and muscle wasting in patients with chronic heart failure显示文摘 | Moriya J Yasumura Y | 2004 | Circulation2004，110，24： | 1 |
| 11 | Plasma brain natriuretic peptide Levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension显示文摘 | Nagaya N Nishikimi T Okano Y | 1998 | J Am Coll Cardiol1998，31，1： | 1 |
| 12 | Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples 显示文摘 | Hosoda H Doi K Nagaya N | 2004 | Clin Chem2004，50，： | 1 |
| 13 | Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid显示文摘 | Mar CK Eimoto T Nagaya S | 2006 | Histopathotogy2006，48，7： | 1 |
| 14 | Sustained elevation of plasma brain natriuretic peptide levels associated with progressive ventricttlar remodelling after acute myocardial infarction显示文摘 | Nagaya N Goto Y Nishikimi T | 1999 | Clin Sci (Lond)1999，96，2： | 1 |
| 15 | Sustained elevation of plasma brain natriuretic peptide levels associated with progressive ventricular remodeling after acute myocardial infarction 显示文摘 | Nagaya N Goto Y Nishikimi T | 1999 | Clin Sci ( Lond)1999，96，2： | 1 |
| 16 | Markers of insulin resistance in day and shift workers aged 30–59 years显示文摘 | Teruo Nagaya Hideyo Yoshida Hidekatsu Takahashi Makoto Kawai | 2002 | International Archives of Occupational and Environmental Health2002，，8： | 1 |
| 17 | Preoperative evaluation of hepatic functional reserve following hepatectomy by technetium-99m galactosyl human serum albumin liver scintigraphy and computed tomography显示文摘 | Akihito Mitsumori Isao Nagaya Shin Kimoto Shiro Akaki Izumi Togami Yoshihiro Takeda Ikuo Joja Yoshio Hiraki | 1998 | European Journal of Nuclear Medicine1998，，10： | 1 |
| 18 | Analysis of patients with congenital diaphragmatic hernia requiring pre-operative extracorporeal membrane oxygenation (ECMO)显示文摘 | Nagaya M Kato J Niimi N | 1998 | Pediatr Surg Int1998，14，12： | 1 |
| 19 | Hemodynarnic and hormonal effects of human ghrelin in healthy volunteers显示文摘 | Nagaya N Kojima M Uematsu M | 2001 | Am J Physiol Regul Intogr Camp Physiol2001，280，5： | 1 |
| 20 | Oral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary pulmonary or thromboembolic pulmonary hypertension显示文摘 | Nagaya N Shimizu Y Satoh T | 2002 | Heart2002，87，4： | 1 |
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