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1Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO.Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy 2005World Journal of Gastroenterology2005,11,21:11
2Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting显示文摘Nagy N Legendre H Engels O 2003Cancer2003,97,8:1
3Open reduction and internal fixation of volar Barton's fractures:a prospective study 显示文摘Aggarwal A K Nagi O N 2004J Orthop Surg2004,12,2:1
4Doseresponse relationship to inhaled endotoxin in normal subjects 显示文摘MICHEL O NAGY A M SCHROEVEN M 1997Am J Respir Crit Care Med1997,156,:1
5查看详情显示文摘Spevak W Nagy J O Charych D H 0,,:1
6Delayed exercise-induced protection against arrhythmias in dogs--effect of celecoxib显示文摘Nagy O Hajnal A Parratt JR 2004Eur J Pharmacol2004,499,12:1
7Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assemble 显示文摘Charych D H Nagy J O Spevak W 1993Science1993,261,58:1
8Identification of vaccine candidate antigens of Staphylococcus aureus by serological proteome analysis 显示文摘Vytvytska O Nagy E Bluggel M 2002Proteomics2002,2,5:1
9Inhibition of micmflora assoeiated with oral malignancy显示文摘Nagy K keI O Sonkodi I 2000Oral Oncol2000,,:1
10Genome sequence and analysis of the tuber crop potato显示文摘Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G 2011Nature2011,475,7355:1
11Influence of physico-chemical control and of membrane composition on the coupled transport of copper(Ⅱ) ions through bulk liquid membranes显示文摘Scpakowska M Nagy O B 2000Journal of Membrane Science2000,168,:1
12Nitric oxide involvement in the delayed antiarrhythmic effect of treadmill exercise in dogs显示文摘Hajnal A Nagy O Litvai A 2005Life Sci2005,77,16:1
13Refined prognostic evaluation in colon carcinoma using immunohistochemicalgalectin fingerprinting显示文摘Nagy N Legendre H Engels O 2003Cancer2003,97,8:1
14查看详情显示文摘Nagy J O Bednarski M D 0,,:1
15Stabilit of supported liquid membranes containing Acorga P-50 as carrier显示文摘Szpakowska M Nagy O B 1997Journal of membrane science1997,,129:1
16D-dimer as a potential prognostic marker显示文摘Nagy Z Horv6th O K6das J 2012Pathol Oncol Res2012,30,18:1
17D-dimer as a potential prognosticmarker显示文摘Nagy Z Horváth O Kádas J 2012Pathol Oncol Res2012,18,3:1
18Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones显示文摘Maes C Goossens S Bartunkova S Drogat B Coenegrachts L Stockmans I Moermans K Nyabi O Haigh K Naessens M Haenebalcke L Tuckermann JP Tjwa M Carmeliet P Mandic V David J-P Behrens A Nagy A Carmeliet G Haigh JJ 0,,:1
19Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice 显示文摘A1-Shabanah O A Alam K Nagi M N 1999Life Sci1999,66,3:1
20Nitric oxide in- volvement in the delayed antiarrhythmic effectof tread- mill exercise in dogs显示文摘Hajnal A Nagy O Litvai A 2005Life Sci2005,77,16:1
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