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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Analysis of Alloys by Prompt Gamma-ray Neutron Activation显示文摘 | Nair AGC Sudarshan K Raje N | 2004 | Nuclear Instruments and Methods in Physics Research A2004，516，1： | 1 |
| 3 | Biocompatibility of b-tricalcium phosphate root replicas in porcine tooth extraction sockets-A correlative histological,ultrastructural,and Xray microanalytical pilot study显示文摘 | Nair P N R Luder H U Maspero F A | 2006 | J Biomater Appl2006，20，： | 1 |
| 4 | Adsorption and Photocatalytic Oxidation of Acetone on TiO2 :An in Situ Transmission FT-IR Study显示文摘 | El-Maazawi M Finken A N Nair A B | 2000 | Catal2000，191，： | 1 |
| 5 | Fine Structure Constant Defines Visual Transparency of Graphene显示文摘 | Nair R R Blake P Grigorenko A N | 2008 | Science2008，320，5881： | 1 |
| 6 | Determination of optical parameters of human breast tissue from spatially resolved fluorescence: a diffusion theory model 显示文摘 | Nair M Ghosh N Raju N | 2002 | Appl Opt2002，41，19： | 1 |
| 7 | Production of artemisinin in tissue cultures of Artemisia annua显示文摘 | Nair M S R Acton N Klayman D C | 1986 | J Nat Prod1986，49，3： | 1 |
| 8 | Investigations on the cure chemistry and polymer properties of benzoxazine - eyanate ester blends显示文摘 | Santhosh Kumar K S Reghunadhan Nair C P Ninan K N | 2009 | European Polymer Journal2009，45，2： | 1 |
| 9 | In-plane and transverse rubber composites显示文摘 | Das J N Nair N G Subramaniam N | 1993 | Rubber and Composites:Processing and Applications1993，22，： | 1 |
| 10 | Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana 显示文摘 | JAYAPRAKASAM B SEERAM N P NAIR M G | 2003 | Cancer Letters2003，189，1： | 1 |
| 11 | Fine structure constant defines visual transparency of graphene显示文摘 | Nair R R Blake P Grigorenko A N | 2008 | Science2008，320，5881： | 1 |
| 12 | L - arginine supplementation in peripheral arterial disease: no benefit and possible harm 显示文摘 | Wilson AM Harada R Nair N | 2007 | Circulation2007，116，2： | 1 |
| 13 | Pemetrexed/gemcitabine as front-line therapy for advanced NSCLC:A randomized,phase Ⅱtrial of three schedules显示文摘 | Adjei AA Nair S Reuter N | 2004 | Proc Am Soc Clin Oncol2004，23，： | 1 |
| 14 | Pathophysiologyandmanagementofneurocar-diogenicsyncope显示文摘 | Nair N Padder FA Kantharia BK | 2003 | Am J Manag Care2003，9，4： | 1 |
| 15 | Fuzzy Models for Single-period Inventory Problem 显示文摘 | Li L Kabadi S N Nair K P K | 2002 | Fuzzy sets and systems2002，，132： | 1 |
| 16 | Phosphazene Triazine Cyclomatrix Network Polymers:Some Aspects of Synthesis, Thermal- and Flame-retardant Characteristics显示文摘 | Mathew D Nair C P R Ninan K N | 2000 | Polym Int2000，49，1： | 1 |
| 17 | Serum proealcitonin and infective exacerbations of asthma显示文摘 | Dsilva L Hassan N Nair P | 2011 | Chest2011，140，5： | 1 |
| 18 | An overview of the recent developments in polyl_actide ( PEA ) research 显示文摘 | Madhavan Nampoothiri K Nair N R John R P | 2010 | Bioresource Technol2010，101，22： | 1 |
| 19 | Characterization of polystyrene filled with HgS nanoparticles显示文摘 | P Sreekumari Nair T Radhakrishnan N Revaprasadu | 2004 | Materials Letter2004，58，34： | 1 |
| 20 | Permutation Entropy Based Real-Time Chatter Detection Using Audio Signal in Turning Process显示文摘 | Nair U Krishna B M Namboothiri V N N | | 0，，01： | 1 |
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