|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mycobacterium avium subspecies paratuberculosis causes Crohn's disease in some inflammatory bowel disease patients显示文摘Crohn’s disease(CD)is a chronic inflammatory condition that plagues millions all over the world.This debilitating bowel disease can start in early childhood and continue into late adulthood.Signs and symptoms are usually many and multiple tests are often required for the diagnosis and confirmation of this disease.However,little is still understood about the cause(s)of CD.As a result,several theories have been proposed over the years.One theory in particular is that Mycobacterium avium subspecies paratuberculosis(MAP)is intimately linked to the etiology of CD.This fastidious bacterium also known to cause Johne’s disease in cattle has infected the intestines of animals for years.It is believed that due to the thick,waxy cell wall of MAP it is able to survive the process of pasteurization as well as chemical processes seen in irrigation purification systems.Subsequently meat,dairy products and water serve as key vehicles in the transmission of MAP infection to humans(from farm to fork)who have a genetic predisposition,thus leading to the development of CD.The challenges faced in culturing this bacterium from CD are many.Examples include its extreme slow growth,lack of cell wall,low abundance,and its mycobactin dependency.In this review article,data from 60 studies showing the detection and isolation of MAP by PCR and culture techniques have been reviewed.Although this review may not be 100%comprehensive of all studies,clearly the majority of the studies overwhelmingly and definitively support the role of MAP in at least30%-50%of CD patients.It is very possible that lack of detection of MAP from some CD patients may be due to the absence of MAP role in these patients.The latter statement is conditional on utilization of methodology appropriate for detection of human MAP strains.Ultimately,stratification of CD and inflammatory bowel disease patients for the presence or absence of MAP is necessary for appropriate and effective treatment which may lead to a cure. | Saleh A Naser Sudesh R Sagramsingh Abed S Naser Saisathya Thanigachalam | 2014 | World Journal of Gastroenterology2014，20，23： | 9 |
| 2 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 3 | Association between hyperhomoeysteinaemia and hypertension in Sri Lankans显示文摘 | Mendis S Athauda SB Naser M | 1999 | J Int Med Res1999，27，1： | 1 |
| 4 | Preparation of polystyrene/poly(vinyl acetate) nanocomposites with a core-shell structure via emulsifier-free emulsion polymerization显示文摘 | Morteza S D Naser S S Nader N | 2006 | Journal of Applied Science2006，100，： | 1 |
| 5 | Stability of vertically bent pipelines buried insand 显示文摘 | Sahel N A Hamdan N A Junaid A S Ibrahim M A Naser A A | 2004 | Journal of Pressure Vessel Technology Transactions of the ASME2004，126，3： | 1 |
| 6 | Simulation of smoke from a burning vehicle and pollution levels caused by traffic jam in a road tunnel显示文摘 | BARI S NASER J | 2005 | Tunnelling and Underground Space Technology2005，20，： | 1 |
| 7 | Preparation of organic-inorganic nanocomposites with core-shell structure by inorganic powders显示文摘 | Nader N Naser S Baharak K N | 2006 | Appl Polym Sci2006，99，： | 1 |
| 8 | Activated clotting time level with weight based heparin dosing during percutaneous coronary intervention and its de- terminant factors 显示文摘 | Majid S Naser A Bahram S | 2014 | J Cardiovasc Thorac Res2014，6，2： | 1 |
| 9 | The effect of replacement feeding of some protein sources with pollen on honey bee population and colony performance显示文摘 | MOHAMMAD R D NASER M S ABOLFAZL A G | 2007 | Journal of Animal and Veterinary Advances2007，6，11： | 1 |
| 10 | Navigation Kalman Filter Design for Pipeline Pigging显示文摘 | Eun H S Naser E S | 2005 | The Jurnal of Navigation2005，58，1： | 1 |
| 11 | Association between hyperhomcysteinaemia and hypertension in Sfilankans 显示文摘 | Mends S Athanda SB Naser M | 1999 | Int Med Res1999，27，1： | 1 |
| 12 | Deep Nondestructive testing using a bulk high T,rf-SQUID显示文摘 | Naser S Alzayed Fan Changxin Lu D F | 1994 | Ieee Transaction on Applied Superconductivity1994，4，2： | 1 |
| 13 | An Unscented Kalman Filter for In-Motion Alignment of Low-Cost IMUs 显示文摘 | Eun H S Naser E | 2004 | IEEE Explore2004，1，： | 1 |
| 14 | Methane emissions from five paddy fields with different amounts of rice straw application in central Hokkaido,Japan显示文摘 | Naser HM Nagata O Tamura S | 2007 | Soil Science and Plant Nutrition2007，53，： | 1 |
| 15 | Association between hyperhomocysteinaemia and hypertension in Sri Lankans 显示文摘 | Mendis S Athauda SB Naser M | 1999 | J Int Med Res1999，27，1： | 1 |
| 16 | Association between hyperhomocyateinaemia and hypertension in Sri - Lan -kans 显示文摘 | Mendis S Athauda SBP Naser M | 1999 | J Int Med Res1999，27，1： | 1 |
| 17 | Simulation of airflow and pollution levels caused by severe traffic jam in a road tunnel显示文摘 | Bari S Naser J | 2010 | Tunnelling and Underground Space Technology2010，25，1： | 1 |
| 18 | Association between hyperhomocysteinaemia and hypertension in Sri Lankans显示文摘 | Mendis S Athauda SB Naser M | 1999 | Int Med Res1999，27，1： | 1 |
| 19 | Identification of lactobacilli by pheS and rpoA gene sequence analyses 显示文摘 | Naser S M Dawyndt P Hoste B | 2007 | Intemational Journal of System Evolutionary Microbiology2007，57，： | 1 |
| 20 | Simulation of smoke from a burning vehicle and pollution levels caused by traffic jam in a road tunnel显示文摘 | BARI S NASER J | 2005 | Tunnelling and Underground Spaceechnology2005，20，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员