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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 3 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 4 | The health and economic benefits associated with pneumococcal vaccination of elderly persons with dhronic lung disease显示文摘 | Nichol KL Baken L Wurenma J | 1999 | Arch Intern Med1999，159，： | 1 |
| 5 | Assessment of BLS skills, Optimizing use of instructor and manikin measures显示文摘 | LYNCH B EINSPRUCH E L NICHOL G | 2008 | Resuscitation2008，76，2： | 1 |
| 6 | Pharmacodynamics and pharmacokinetics of AMG-531, a novel thrombopoietin receptor ligand 显示文摘 | Wang B Nichol J L Sullivan J T | 2004 | Clin Pharm Ther2004，76，6： | 1 |
| 7 | Swine manure characterization as affected by environmental-temperature, dietary level intake, and dietary-fat addition显示文摘 | Clanton C J Nichols D A Moser R L | 1991 | Transactions of the ASAE1991，34，： | 1 |
| 8 | Lagoon subsidence and tsunami on the West Coast of New Zealand 显示文摘 | Nichol S L Goff J R Devoy R J N | 2007 | Sedimentary Geology2007，200，： | 1 |
| 9 | Primary non-Hodgkin's lymphoma of lung: A study of 161 patients 显示文摘 | Koss MN Hochholzer L Nichols PW | 1983 | Hum Pahtol1983，14，19： | 1 |
| 10 | Rapid detection of vesicular stomatitis virus New Jersey serotype in clinical samples by using polymerase chain reaction显示文摘 | Rodriguez L L Lecthworth G J Nichol S T | 1993 | J Clin Microbiol1993，31，： | 1 |
| 11 | A randomised controlled trial of pre-hospital intravenous fluid replacement therapy in serious trauma 显示文摘 | Turner J Nicholl J Webber L | 2000 | Health Technol Assess2000，4，31： | 1 |
| 12 | Effectiveness of a 30-min CPR self-instruction program for lay responders: a controlled randomized study显示文摘 | LYNCH B EINSPRUCH E L NICHOL G | 2005 | Resuscitation2005，67，1： | 1 |
| 13 | Assessment of current turbine engine high cycle fatigue test methods显示文摘 | Nichol K L | 2003 | ASME Journal of Engineering for Gas Turbines and Power2003，125，3： | 1 |
| 14 | Primary non-Hodgkin's lymphoma and pseudolymphoma of lung:a study of 161 patients显示文摘 | Koss MN Hochholzer L Nichols PW | 1983 | Human pathology1983，14，： | 1 |
| 15 | Fuel ethanol from cellulosic biomass显示文摘 | Lind L R Cushman J H Nichols R J | 1992 | Science1992，251，： | 1 |
| 16 | Promoting early detection in leprosy-a literature review to identify proven and potential interventions addressing patient-related delay显示文摘 | Nicholls PG Ross L Smith WC | 2006 | Lepr Rev2006，77，4： | 1 |
| 17 | Low gradient permeability measurements in a triaxial system 显示文摘 | Nichols R W Rice T L | 1985 | Geotechnique1985，35，2： | 1 |
| 18 | Variability among Chinese Glycine soja and Chinese and North American soybean genotypes显示文摘 | Nichols D Wang L Z Pei Y L | 2007 | Crop Science2007，47，： | 1 |
| 19 | A Rac homolog functions downstream of Rasl to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans显示文摘 | Vallim M A Nichols C B Fernandes L | 2005 | Eukaryotic Cell2005，4，6： | 1 |
| 20 | Management of young goats during prolonged fasting affects carcass characteristics but not pre-slaughter live weight or cortisol显示文摘 | Greenwood P L Finn J A May T J Nicholls P J | | 0，，06： | 1 |
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