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| 1 | ABC transporters and the hallmarks of cancer:roles in cancer aggressiveness beyond multidrug resistance显示文摘The ATP-binding cassette transporters(ABC transporters)have been intensely studied over the past 50 years for their involvement in the multidrug resistance(MDR)phenotype,especially in cancer.They are frequently overexpressed in both naive and post-treatment tumors,and hinder effective chemotherapy by reducing drug accumulation in cancer cells.In the last decade however,several studies have established that ABC transporters have additional,fundamental roles in tumor biology;there is strong evidence that these proteins are involved in transporting tumor-enhancing molecules and/or in protein-protein interactions that impact cancer aggressiveness,progression,and patient prognosis.This review highlights these studies in relation to some well-described cancer hallmarks,in an effort to re-emphasize the need for further investigation into the physiological functions of ABC transporters that are critical for tum or development.Unraveling these new roles offers an opportunity to define new strategies and targets for therapy,which would include endogenous substrates or signaling pathways that regulate these proteins. | Wanjiru Muriithi Lucy Wanjiku Macharia Carlos Pilotto Heming Juliana Lima Echevarria Atunga Nyachieo Paulo Niemeyer Filho Vivaldo Moura Neto | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 2 | Development, Processing and Applications Range of Magnesium Lithium Alloys显示文摘 | Haferkamp H. Niemeyer M. Boehm R. Holzkamp U. Jaschik Christian Kaese V | 2000 | Materials Science Forum2000，，350： | 3 |
| 3 | Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones显示文摘AIM An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid components of hepatic and gallbladder bile and its viscosity in patients with gallstones.METHODS Viscosity of bile ( mpa. s ) wasmeasured using rotation viscosimetry in regard to the non-Newtonian property of bile at law shear rates.RESULTS Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 ± 0.60 mpa. s, mean ± SEM, n --28) and mixed stones (3.50±0.68 mPa. s; n =8) compared to hepatic bile (0.92 ± 0.06 mpa. s,n -6). A positive correlation between mucin and viscosity was found in gallbladder biles (r=0.65; P<0.001) but not in hepatic biles. The addition of physiologic and supraphysiologic amounts of mucin to gallbladder bile resulted in a dose dependent non linear increase of its viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P<0.005) in gallbladder biles. However, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles.CONCLUSION The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones. | Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer Martin Wilhelmi Reginalddel Pozo | 2001 | World Journal of Gastroenterology2001，7，2： | 2 |
| 4 | 以亚琛数字能力中心为例浅析学习工厂4.0的教学方法显示文摘工业4.0迫使企业重新审视并完善发展其商业模式与产品。无论在技术还是人才方面,企业都面临着严峻的挑战。在此,学习工厂4.0可以为企业成功地应对这些挑战提供必要的支持。亚琛数字能力中心DCC是学习工厂很好的一个示例,其教学旨在培养企业员工的数字化能力,并为企业在数字化转型的道路上给予支持。为此,该学习工厂展示的是最新的数字解决方案,并通过提供量体裁衣的工作坊和培训,使员工能够为进入全新的职业世界做好准备。 | Consuelo Leona Niemeyer Nicolina Prass | 2020 | 应用型高等教育研究2020，5，2： | 2 |
| 5 | Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension: a beneficial side effect 显示文摘 | Cleophas TJ Grabewsky I Niemeyer MG | 2002 | Circulation2002，105，： | 1 |
| 6 | Immuno-PCR: High sensitivity detection of proteins by nucleic acid amplification 显示文摘 | Niemeyer C M Adler M Wacker R | 2005 | Trends Biotechnol2005，23，4： | 1 |
| 7 | Fractal dimen- sion of dielectric breakdown显示文摘 | Niemeyer L Piwtronero L Wiesmann H J | 1984 | Phys Rev Lett1984，52，12： | 1 |
| 8 | Anterior thoracoscopic surgery followed by posterior instrumentation and fusion in spinal deformity显示文摘 | Niemeyer T Freeman BJC Grevitt MP | 2000 | Eur Spine J2000，9，6： | 1 |
| 9 | Magnetic tunnel junctions with compensated magnetic moment by directly exchange-coupled NiFe/CoGd/NiFe trilayers 显示文摘 | NIEMEYER A REISS G BRUCKL H | 2006 | Appl Phys Lett2006，88，18： | 1 |
| 10 | A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative disease显示文摘 | Hasle H Niemeyer CM Chessells JM | 2003 | Leukemia2003，17，2： | 1 |
| 11 | Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: molecular classification and treatment options显示文摘 | Niemeyer CM Kratz CP | 2008 | Br J Haematol2008，140，6： | 1 |
| 12 | Confirmatory analysis of field- presumptive GSR test sample using SEM/EDS显示文摘 | Toal S J Niemeyer W D Conte S | 2014 | Proceedings of SPIE-The International Society for Optical Engineering2014，9236，92： | 1 |
| 13 | Fractal dimension of dielectric breakdown显示文摘 | Niemeyer L Piotronero L Weismann H J | 1984 | Physical Review Letters1984，52，14： | 1 |
| 14 | DNA-directed functionalization of colloidal gold with proteins 显示文摘 | Niemeyer C M Ceyhan B | 2001 | Angew Chem Int Ed Engl2001，40，19： | 1 |
| 15 | Stem cell transplantation for aplastic anemia an dmyelodysplastic syndrome显示文摘 | Stary J Locatelli F Niemeyer CM | 2005 | Bone Marrow Transplant2005，1，： | 1 |
| 16 | Control of microrna-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/ras signaling and its transcription factors 显示文摘 | Kern H B Niemeyer B F Parrish J K | 2012 | DNA Cell Biol2012，31，8： | 1 |
| 17 | Stable adaptive teleop- eration 显示文摘 | NIEMEYER G SLOTINE J J E | 1991 | IEEE Journal of Oceanic Engineering1991，16，1： | 1 |
| 18 | Telemanipulation with time delays显示文摘 | Niemeyer G | 2004 | The International Journal of Robotics Research2004，23，9： | 1 |
| 19 | Does a hyperon- eotic eardiopulmonary bypass prime affect extravaseular lung water and cardiopulmonary function in patients undergoing coronary artery bypass surgery显示文摘 | Eising GP Niemeyer M Gtinther T | 2001 | Eur J Cardiothorac Surg2001，20，2： | 1 |
| 20 | Dendrimer-activated solid supports for nucleic acid and protein microarrays显示文摘 | Benters R Niemeyer CM Wohrle D | 2001 | Chembiochem2001，2，9： | 1 |
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