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| 1 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?显示文摘Growing prevalence of diabetes(type 2 as well as type 1) and its related morbidity due to vascular complications creates a large burden on medical care worldwide. Understanding the molecular pathogenesis of chronic micro-, macro- and avascular complications mediated by hyperglycemia is of crucial importance since novel therapeutic targets can be identified and tested. Thiamine(vitamin B1) is an essential cofactor of several enzymes involved in carbohydrate metabolism and published data suggest that thiamine metabolism in diabetes is deficient. This review aims to point out the physiological role of thiamine in metabolism of glucose and amino acids, to present overview of thiamine metabolism and to describe the consequences of thiamine deficiency(either clinically manifest or latent). Furthermore, we want to explain why thiamine demands are increased in diabetes and to summarise data indicating thiamine mishandling in diabetics(by review of the studies mapping the prevalence and the degree ofthiamine deficiency in diabetics). Finally, we would like to summarise the evidence for the beneficial effect of thiamine supplementation in progression of hyperglycemia-related pathology and, therefore, to justify its importance in determining the harmful impact of hyperglycemia in diabetes. Based on the data presented it could be concluded that although experimental studies mostly resulted in beneficial effects, clinical studies of appropriate size and duration focusing on the effect of thiamine supplementation/therapy on hard endpoints are missing at present. Moreover, it is not currently clear which mechanisms contribute to the deficient action of thiamine in diabetes most. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given. | Luká? Pácal Katarína Kuricová Katerina Kaňková | 2014 | World Journal of Diabetes2014，5，3： | 3 |
| 3 | Hydrogels in pharmaceutical formulation显示文摘 | Peppas NA Bures P Leobandung W | 2000 | Eur J Pharm Biopharm2000，50，1： | 2 |
| 4 | 高密度脂蛋白可追踪脑卒中恢复情况显示文摘前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。 | Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ Fazio S Pamir N 刘青(译) 刘莉(摘/审校) | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 5 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 6 | Growth factors as therapeutics for diabetic neuropathy显示文摘 | CALCUTT NA JOLIVAH CG FERNYHOUGH P | 2008 | Curt Drug Tmgets2008，9，1： | 1 |
| 7 | 3,5-Dimethylphenylcar- barnates of amylose, chitosan and cellulose bonded on silica gel Com- parison of their chiral recognition abilities as high-performance liquid chromatography chiral stationary phases显示文摘 | Franco P Senso A Minguillo'na C | 1998 | J Chromatography A1998，，： | 1 |
| 8 | Oncocytic renal neoplasmsdiagonostic considerations显示文摘 | ABRAHAMS NA TAMBOLI P | 2005 | Clin Lab Med2005，25，2： | 1 |
| 9 | Role of Rel/NF-kappa B tran- scription factors in apoptosis of human hepatocellular carcinoma cells 显示文摘 | CHIAO P J NA R NIU J | 2002 | Cancer2002，95，8： | 1 |
| 10 | Nomenclature of human platelet antigens 显示文摘 | Metcalfe P Watkins NA Ouwehand WH | 2003 | Vox Sang2003，85，3： | 1 |
| 11 | A highly efficient recombineering- based method for generating conditional knockout mutations 显示文摘 | Liu P Jenkins NA Copeland NG | 2003 | Genome Res2003，13，3： | 1 |
| 12 | Seleral remodeling during the development and recovery from axial myopia in the tree shrew 显示文摘 | Mcbrien NA Lawlor P Gentle A | 2000 | Invest Ophthalmol Vis Sei2000，41，12： | 1 |
| 13 | Electro- physiological correlates of respiratory failure in acute organo- phosphate poisoning: evidence for differential roles of musca- rinic and nicotinic stimulation显示文摘 | Jayawardane P Senanayake N Buekley NA | 2012 | Clin Toxicol(Phila)2012，50，4： | 1 |
| 14 | Dengue shock syndrome in an infant 显示文摘 | Aurpibul L Khumlue P Issaranggoon na ayuthaya S | 2014 | BMJ Case Rep2014，，20： | 1 |
| 15 | Abnormal calcium homeostasis in pe- ripheral neuropathies显示文摘 | Femyhough P Calcutt NA | 2010 | Cell Calcium2010，47，： | 1 |
| 16 | Antibacterial activity of chitosans and chitosan oligomers with different molecular weights显示文摘 | Hong K N Na Y P Shin H L | 2002 | International Journal of Food Microbiology2002，，74： | 1 |
| 17 | A highly efficient recombineering-based method for generating conditional knockout mutations显示文摘 | Liu P Jenkins NA Copeland NG | 2003 | Genome Res2003，13，3： | 1 |
| 18 | A finite ele- ment model of the shoulder: applicationto the comparison of normal and osteoarthritic joints 显示文摘 | Buchler P Ramaniraka NA Rakotomanana LR | 2002 | Clin Biomech2002，910，： | 1 |
| 19 | Identification of adhesions on CT in small-bowel obstruction 显示文摘 | Petrivic B Nikolaidis P Hammond NA | 2006 | Emerg Radiol2006，12，3： | 1 |
| 20 | Modified grid algorithm for noisy all-sky autonomous star identification显示文摘 | Na M Zheng D N Jia P F | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，2： | 1 |
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