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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 3 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 4 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 5 | Adsorption of thiacyanine dyes on silver hilide nanoparticles:study of the adsorption site显示文摘 | Jeunieau L Alin V Nagy B | 2000 | Langmuir2000，16，： | 1 |
| 6 | Enterotoxigenic Escherichia coli (ETEC) in farm animal显示文摘 | NAGY B FEKETE P Z | 1999 | VET Res1999，30，： | 1 |
| 7 | Primary small bowel tumors:a radiologic-pathologic correlation显示文摘 | Verma V Vaiphei K | 2001 | Abdom Imaging2001，26，5： | 1 |
| 8 | Enterotoxigenic Escherichia coli, rotavirus, porcine epidemic diarrhoea virus, adenovirus and calici-like virus in porcine postweaning diarrhoea in Hungary 显示文摘 | NAGY B NAGY G MEDER M | 1996 | Acta Vet Hung1996，44，1： | 1 |
| 9 | Enterotoxigenic Escherichia coil(ETEC) in farm animial显示文摘 | NAGY B FEKETE P Z | 1999 | VET Res1999，30，23： | 1 |
| 10 | Carbohydrates as ligands: coordination equilibria and structure of the metal complexes显示文摘 | Gyurcsik B Nagy L | 2000 | Coordination Chemistry Reviews2000，203，1： | 1 |
| 11 | Elevated human epididymis protein 4 concentrations inchronic kidney disease显示文摘 | Béla Nagy Jr Krasznai ZT Balla H | 2012 | Ann Clin Biochem2012，49，4： | 1 |
| 12 | Incorporation of boron in tetrahedral sites of ZSM-5 framework during crystallization: a high resolution solid state MAS H B-NMR study 显示文摘 | Gabelica Z Debras G Nagy B | 1984 | Stud Surf Sci Catal1984，，19： | 1 |
| 13 | etc The study of carbon nanotubes produced by catalytic method显示文摘 | Ivanov V Nagy J B Lambin P | 1994 | Chem Phys Lett1994，223，： | 1 |
| 14 | Polymer structure and antimicrobial activity of polyvinylpyrrolidone-based iodine nanofibers prepared with high-speed rotary spinning technique显示文摘 | Sebe I Szabo B Nagy ZK | 2013 | Int J Pharm2013，458，1： | 1 |
| 15 | The cost-effectiveness of ulipristal acetate tablets in treating patients with moderate to severe symtoms of uterine fibroids显示文摘 | Nagy B Timar G Jozwiak-Hagymasy J | 2014 | Eur J Obstet Gynecol Reprod Biol2014，，175： | 1 |
| 16 | Catalytic production and purification of nanotubules having fullerence-seale diameter显示文摘 | Vanov V I Fonseca A Nagy J B | 1995 | Carbon1995，33，12： | 1 |
| 17 | Enterotoxigenic Escherichia coli,rotavirus,porcine epidemic diarrhoea virus,adenovirus and calici-like virus in porcine postweaning diarrhoea in Hungary显示文摘 | Nagy B Nagy G Meder M | 1996 | Acta Vet Hung1996，44，1： | 1 |
| 18 | High frequency of methylenetetrahydr-ofolate reductase 677TT genotype in Hungarian HELLP syndromepatients determined by quantitative real-time PCR显示文摘 | Nagy B’Hupuczi P Papp Z | 2007 | J HumHypertens2007，21，2： | 1 |
| 19 | 13C NMR quantitative analysis of catalyst carbon deposits显示文摘 | FONSECA A ZEUTHEN P NAGY J B | 1996 | Fuel1996，75，12： | 1 |
| 20 | Autopsy versus clinical findings in patients with systemic sclerosis in a case series from patients of the EUSTAR database显示文摘 | Sandmeier B J?ger VK Nagy G | 2015 | Clin Exp Rheumatol2015，91，4： | 1 |
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