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| 1 | Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review显示文摘Neuroendocrine carcinoma (NEC) of the extrahepatic bile duct is rare, and only 22 cases have been reported. Only two of these were large-cell NEC (LCNEC); the vast majority were small-cell NEC. Here, we report a third case of LCNEC of the extrahepatic bile duct. A 76-year-old male presented to a local hospital with painless jaundice. Imaging studies revealed a tumor at the hepatic hilum. The patient underwent right hepatic lobectomy, bile duct resection, and cholecystectomy. The resection specimen showed a 5.0-cm invasive neoplasm involving the hilar bile ducts and surrounding soft tissue. Histologically, the tumor consisted of nests of medium to large cells with little intervening stroma. The tumor invaded a large portal vein branch. All four excised lymph nodes were positive for metastasis, and metastatic deposits were also present in the gallbladder wall. The tumor was diffusely positive for synaptophysin and focally positive for chromogranin A. Approximately 70%-80% of the tumor cells were positive for Ki-67, indicating strong proliferative activity. A diagnosis of LCNEC was made. A few bile ducts within and adjacent to the invasive tumor showed dysplasia of the intestinal phenotype and were focally positive for synaptophysin and chromogranin A, suggesting that the dysplastic intestinal-type epithelium played a precursor role in this case. A postoperative computer tomography scan revealed rapid enlargement of the abdominal and retroperitoneal lymph nodes. The patient died 21 d after the operation. NEC of the bile duct is an aggressive neoplasm, and its biological characteristics remain to be better defined. | Eizaburo Sasatomi Michael A Nalesnik J Wallis Marsh | 2013 | World Journal of Gastroenterology2013，19，28： | 4 |
| 2 | Bridging Locoregional Therapy for Hepatocellular Carcinoma Prior to Liver Transplantation显示文摘 | Jason T. Heckman MD Michael B. deVera MD J. Wallis Marsh MD MBA Paulo Fontes MD Nikhil B. Amesur MD Shane E. Holloway MD Michael Nalesnik MD David A. Geller MD Jennifer L. Steel PhD T. Clark Gamblin MD MS | 2008 | Annals of Surgical Oncology2008，，11： | 2 |
| 3 | The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression 显示文摘 | Nalesnik M A Jaffe R Starzl T E | 1988 | Am J Pathol1988，133，： | 1 |
| 4 | Enhanced synthesis and reduced metabolism of endothelin-1 (ET-1) by hepatocytes-an important mechanism of increased endogenous levels of ET-1 in liver cirrhosis显示文摘 | KUDDUS R H NALESNIK M A SUBBOTIN V M | 2000 | J Hepatol2000，33，： | 1 |
| 5 | Microchimerism, GVHD, and tolerance in solid organ transplantation 显示文摘 | Triulzi DJ Nalesnik MA | 2001 | Transfusion2001，41，3： | 1 |
| 6 | The effects of FK506 on the lewis rat renal ischemia model显示文摘 | Nalesnik MA Lai HS Todo S | 1990 | Transplant Proc1990，22，： | 1 |
| 7 | Epstein-Barr virus-induced posttransplant lymphoproliferative disorders, ASI/ASIP EBV-PTLD Task Fome and The Mayo Clinic Organized International Consensus Development Meeting 显示文摘 | Paya CV Fung JJ Nalesnik MA | 1999 | Transplantation1999，68，10： | 1 |
| 8 | Posttransplant lymphoproliferative disorders in liver transplantation:a 20-year experience显示文摘 | Jain A Nalesnik M Reyes J | 2002 | Ann Surg2002，236，4： | 1 |
| 9 | Immunohistochemical evaluation of hepatoblastomas with use of the hepatocyte-specific-marker,hepatocyte paraffin 1,and the polyclonal anti-carcinoembryonic antigen显示文摘 | Fasano M Theise ND Nalesnik M | 1998 | Mod Pathol1998，11，10： | 1 |
| 10 | Porcine cell mi?crochimerism but lack of productive porcine endogenous retrovirus infection in natve and humanized SCID-beige mice treated with porcine peripheral blood mononuclear cells显示文摘 | Kuddus RH Metes DM Nalesnik MA | 2004 | Transpl Immu?nol2004，，13： | 1 |
| 11 | Clinicopathologic characteristics of post-transplant lymphoproliferative disorders显示文摘 | Nalesnik MA | 2002 | Recent Results Cancer Res2002，159，： | 1 |
| 12 | Significance of As- pergillus species isolated from respiratory secretions in the diagno- sis of invasive pulmonary aspergillosis 显示文摘 | Nalesnik MA Myerowitz RL Jenkins R | 1980 | J Clin Microbiol1980，11，4： | 1 |
| 13 | Microchimerism, GVHD, and to- lerance in solid organ transplantation显示文摘 | Triulzi DJ Nalesnik MA | 2001 | Transfusion2001，41，3： | 1 |
| 14 | Minimal evidence of transdif- ferentiation from recipient bone marrow to parenchymal cells in regen- erating and long-surviving human allografts 显示文摘 | Wu T Cieply K Nalesnik MA | 2003 | Am J Transplant2003，3，9： | 1 |
| 15 | Hepatocyteparaffin 1:a monoclonal antibody that reacts with hepatocytes andcan be used for differential diagnosis of hepatic tumors显示文摘 | Wennerberg AE Nalesnik MA Coleman WB | 1993 | Am JPathol1993，143，4： | 1 |
| 16 | Clinicopathologic characteristics of post-transplant lymphoproliferative disorders 显示文摘 | Nalesnik MA | 2002 | Recent Results Cancer Res2002，159，5： | 1 |
| 17 | Epstein- Barr virus - negative post - transplant lymphoproliferative disorders: a distinct entity 显示文摘 | Nelson B P Nalesnik M A Bahler D W | 2000 | Am J Surg Pathol2000，24，3： | 1 |
| 18 | Madaria- ga J:Liver adenomatosis: clinical,histopathologic,and imaging find- ings in 15 patients显示文摘 | Grazioli L Federle MP Ichikawa T Balzano E Nalesnik M | 2000 | Radiology2000，216，： | 1 |
| 19 | Epstein-Barr virus induced posttransplant lymphoproliferative disorder显示文摘 | Paya CV Fung JJ Nalesnik MA | 1999 | Transplantation1999，68，10： | 1 |
| 20 | Hepatocyte paraffin 1:a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors显示文摘 | Wennerberg A Nalesnik M Coleman W | 1993 | Am J Pathol1993，143，： | 1 |
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