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| 1 | Clinical correlates of common corneal neovascular diseases: a literature review显示文摘A large subset of corneal pathologies involves the formation of new vessels(neovascularization), leading to compromised visual acuity. This article aims to review the clinical causes and presentations of corneal neovascularization(CNV) by examining the mechanisms behind common CNV-related corneal pathologies, with a particular focus on herpes simplex stromal keratitis,contact lenses-induced keratitis and CNV secondary to keratoplasty. Moreover, we reviewed CNV in the context of different types of corneal transplantation and keratoprosthesis, and summarized the most relevant treatment available so far. | Nizar Saleh Abdelfattah Mohamed Amgad Amira A Zayed Hamdy Salem Ahmed E Elkhanany Heba Hussein Nawal Abd El-Baky | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 10 |
| 2 | Fast Texture Segmentation Based on Semi-Local Region Descriptor and Active Contour显示文摘In this paper,we present an efficient approach for unsupervised segmentation of natural and textural images based on the extraction of image features and a fast active contour segmentation model.We address the problem of textures where neither the gray-level information nor the boundary information is adequate for object extraction.This is often the case of natural images composed of both homogeneous and textured regions.Because these images cannot be in general directly processed by the gray-level information,we propose a new texture descriptor which intrinsically defines the geometry of textures using semi-local image information and tools from differential geometry.Then,we use the popular Kullback-Leibler distance to design an active contour model which distinguishes the background and textures of interest.The existence of a minimizing solution to the proposed segmentation model is proven.Finally, a texture segmentation algorithm based on the Split-Bregman method is introduced to extract meaningful objects in a fast way.Promising synthetic and real-world results for gray-scale and color images are presented. | Nawal Houhou Jean-Philippe Thiran Xavier Bresson | 2009 | Numerical Mathematics(Theory,Methods and Applications)2009，2，4： | 10 |
| 3 | Recircumscription of Huperzia serrata complex in China using morphological and climatic data显示文摘Huperzia serrata (Thunb ) Trevis。在中国的建筑群分类地包括把 taxa 与不清楚的边界混淆。在这个组的公认的 taxa 的数字长被辩论了并且与这,这个组经历了几个分类变化。H 的种类界限。在中国复杂的 serrata 不适当、未解决并且需要全面系统的研究。处理这些问题,我们试图推断通常认为的 taxa 之间的诊断差别并且约束 H 的种类边界。在用一条综合 multivariate 途径的中国复杂的 serrata。词法人物受到 multivariate 测试(主要部件分析,判别式分析, χ
2-test, 簇分析) 由变化和 Tukey 的 hoc 以后的测试的 univariate 分析列在后面。当模特儿的 MaxEnt 被用来创造壁龛相等和类似测试跟随的种类的分发模型。morphometric 分析清楚地把标本分开了成代表 H 的四不同的簇。crispata (京族) 京族, H。nanlingensis Y. H。Yan 与 N。H 的 Shrestha,和二簇。从地理上孤立的区域包括标本的 serrata。这四不同 taxa 的识别被气候的数据也支持。基于我们的分析与当模特儿的气候的数据和生态的壁龛词法我们认出了 H。crispata, H。nanlingensis,北中国 H。serrata,和南部的中国 H。serrata 作为四不同的种。我们识别了北中国 H。serrata 同样真的 H。serrata 和南部的中国 taxa 作为 H。javanica。然而,我们的结果没支持以前在 H 下面认出的另外的同物种的 taxa 的识别。serrata。 | Nawal Shrestha Xian-Chun Zhang | 2015 | Journal of Systematics and Evolution2015，53，1： | 6 |
| 4 | Molecular underpinnings of corneal angiogenesis:advances over the past decade显示文摘The cornea is maintained in an avascular state by maintaining an environment whereby anti-angiogenic factors take the upper hand over factors promoting angiogenesis. Many of the common pathologies affecting the cornea involve the disruption of such equilibrium and the shift towards new vessel formation, leading to corneal opacity and eventually-vision loss. Therefore it is of paramount importance that the molecular underpinnings of corneal neovascularization(CNV) be clearly understood, in order to develop better targeted treatments. This article is a review of the literature on the recent discoveries regarding pro-angiogenic factors of the cornea(such as vascular endothelial growth factors,fibroblast growth factor and matrix metalloproteinases)and anti-angiogenic factors of the cornea(such as endostatins and neostatins). Further, we review the molecular underpinnings of lymphangiogenesis, a process now known to be almost separate from(yet related to) hemangiogenesis. | Nizar Saleh Abdelfattah Mohamed Amgad Amira A.Zayed Heba Hussein Nawal AbdEl-Baky | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 6 |
| 5 | Cyclin A2:At the crossroads of cell cycle and cell invasion显示文摘Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of Rho A activity. Since this GTPase is involved in both cell rounding early in mitosis and later,in the formation of the cleavage furrow,this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together,these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis. | Abdelhalim Loukil Caroline T Cheung Nawal Bendris Bénédicte Lemmers Marion Peter Jean Marie Blanchard | 2015 | World Journal of Biological Chemistry2015，6，4： | 6 |
| 6 | Spatiotemporal variation in leaf size and shape in response to climate显示文摘叶片的形态变异是研究植物响应气候变化的重要指标之一。叶片大小与形状影响着植物与外界环境的碳、水等物质交换和能量交换。然而,叶片大小与形状如何响应气候变化仍缺乏研究。此外,大多研究忽略了叶大小与形状在时间和空间上的种内变异,而只关注种间变异。我们收集了中国98年(1910-2008年)7个代表性双子叶植物的植物标本馆标本6000多份,并测量了它们叶片的叶长和宽度。我们探索了叶片大小(叶长、叶宽和长×宽乘积)的地理模式和时间趋势,即研究了降水量和温度随时间和空间的变化对叶片大小和形状变化的影响。在控制了标本采集时间的影响后,全部物种的平均叶大小沿着纬度梯度的增加而减小,但这一关系在不同物种间存在差异。叶大小和形状的空间变异与温度和降水正相关。当控制了采集地点的影响后,全部物种的平均叶大小随着时间有变大的趋势。大多数物种叶大小的时间变化与降水正相关,而叶形状的时间变化则与温度正相关。我们的研究指出叶大小和形状在时空上的种内变异显著受气候的影响,同时说明植物标本可以为研究植物形态对气候变化的响应提供素材。 | Yaoqi Li Dongting Zou Nawal Shrestha Xiaoting Xu Qinggang Wang Wen Jia Zhiheng Wang | 2020 | Journal of Plant Ecology2020，13，1： | 4 |
| 7 | A chromosome-scale genome assembly of a diploid alfalfa,the progenitor of autotetraploid alfalfa显示文摘Alfalfa(Medicago sativa L.)is one of the most important and widely cultivated forage crops.It is commonly used as a vegetable and medicinal herb because of its excellent nutritional quality and significant economic value.Based on Illumina,Nanopore and Hi-C data,we assembled a chromosome-scale assembly of Medicago sativa spp.caerulea(voucher PI464715),the direct diploid progenitor of autotetraploid alfalfa.The assembled genome comprises 793.2 Mb of genomic sequence and 47,202 annotated protein-coding genes.The contig N50 length is 3.86 Mb.This genome is almost twofold larger and contains more annotated protein-coding genes than that of its close relative,Medicago truncatula(420 Mb and 44,623 genes).The more expanded gene families compared with those in M.truncatula and the expansion of repetitive elements rather than whole-genome duplication(i.e.,the two species share the ancestral Papilionoideae whole-genome duplication event)may have contributed to the large genome size of M.sativa spp.caerulea.Comparative and evolutionary analyses revealed that M.sativa spp.caerulea diverged from M.truncatula~5.2 million years ago,and the chromosomal fissions and fusions detected between the two genomes occurred during the divergence of the two species.In addition,we identified 489 resistance(R)genes and 82 and 85 candidate genes involved in the lignin and cellulose biosynthesis pathways,respectively.The near-complete and accurate diploid alfalfa reference genome obtained herein serves as an important complement to the recently assembled autotetraploid alfalfa genome and will provide valuable genomic resources for investigating the genomic architecture of autotetraploid alfalfa as well as for improving breeding strategies in alfalfa. | Ao Li Ai Liu Xin Du Jin-Yuan Chen Mou Yin Hong-Yin Hu Nawal Shrestha Sheng-Dan Wu Hai-Qing Wang Quan-Wen Dou Zhi-Peng Liu Jian-Quan Liu Yong-Zhi Yang Guang-Peng Ren | 2020 | Horticulture Research2020，7，1： | 3 |
| 8 | Chemical analysis and antioxidant content of various propolis samples collected from different regions and their impact on antimicrobial activities显示文摘Objective: To assess the antioxidant content, antimicrobial and antioxidant activities of various propolis samples. Methods: Seven propolis samples were collected from different locations in Morocco, which are characterized by different plant predominant vegetations. The resin, wax and balsam of hydroalcoholic extract of propolis content were identified, and the antioxidant content was analyzed with the use of HPLC and colorimetric methods. The antioxidant activity was assessed by DPPH, ABTS.^+ and ferric reducing power assays. The antimicrobial activity was assessed against bacterial species, including methicillin resistant Staphylococcus aureus and Candida albicans, and expressed as the minimal inhibitory concentration. Results: The propolis samples showed significant variations in the chemical composition and in the antioxidant or antimicrobial activities even when the samples were collected from the same location. Propolis with high resin and low wax content had high level of antioxidant compounds, and strong antioxidant and antimicrobial activities. Gram-positive bacteria, especially, methicillin resistant Staphylococcus aureus were more sensitive to all propolis samples than Gram-negative bacteria and Candida albicans. Conclusions: The chemical composition and the antioxidant and antimicrobial activities of various propolis samples are different and rely on the geographic and plant origin of propolis collection. Propolis samples with low wax and high resin content might be more suitable to be used in future preclinical or clinical investigations. | Soumaya Touzani Noori Al-Waili Nawal El Menyiy Bratko Filipic Adriana Pereyra Ilham EL Arabi Wail Al-Waili Badiaa Lyoussi | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，7： | 2 |
| 9 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 10 | Weed seedbank response to tillage and crop rotation in a semi-arid environment显示文摘 | Hani G Nawal A H | 2005 | Soil and Tillage Research2005，84，2： | 1 |
| 11 | Characterization of M-type barium heagonal ferritebased wide band microwave absorber 显示文摘 | Meshram M R Nawal K Agrawal Sinha B | 2004 | J Magn Magn Mater2004，271，： | 1 |
| 12 | Primary osteosarcoma of the breast: case report 显示文摘 | Saber B Nawal A Mohamed F | 2008 | Cases J2008，1，1： | 1 |
| 13 | Improved antibacterial activity of HAPgarlanded PLGA ultrafine fibers incorporated with CuO:synthesis and characterization显示文摘 | Musarat Amina M Shamshi Hassan Nawal Musayeib Al Musayeib | 2014 | Journal of Sol-Gel Science and Technology2014，71，1： | 1 |
| 14 | Characterization of M-type barium hexagonal ferrite-based wide band microwave absorber 显示文摘 | Meshram M R Nawal K Agrawal Bharoti Sinha | 2004 | Journal of Magnetism and Magnetic Materials2004，27，： | 1 |
| 15 | Hydrothermal-ly synthesized high silica mordenite as an efficient catalyst in al-kylation reaction under liquid phase condition 显示文摘 | Sujit Samanta Nawal Kishor Mai Prashant Kumar | 2004 | Journal of Mo-lecular Catalysis A : Chemical2004，，215： | 1 |
| 16 | Characterization of M-type barium hexagonal ferrite-based wide band microwave absorber显示文摘 | Meshram M R Agrawal Nawal K Bharoti Sinha | 2004 | J Magn Magn Mater2004，271，： | 1 |
| 17 | Assessment of left ventriculardiastolic dysfunction in sub-clinical hypothyroidism 显示文摘 | Meena CL MeenaRD Nawal R | 2012 | Acta InformMed2012，20，4： | 1 |
| 18 | Role of cone-beam com- puted tomography in diagnosis of vertical root fractures : a sys- tematic review and recta-analysis 显示文摘 | Talwar S Utneja S Nawal RR | 2016 | J Endod2016，42，1： | 1 |
| 19 | Characterization of Mtype barium hexagonal ferrite-based wide band microwave absorber 显示文摘 | Meshram M R Nawal K A Bharoti S | 2004 | Journal of Magnetism and Magnetic Materials2004，271，： | 1 |
| 20 | Compact analyt- ical threshold-voltage model of nanoscate fully depleted strained-Si on silicon germanium-on insulator (SGOI) MOSFETs 显示文摘 | VIVEK V NAWAL S KUMAR M J | 2007 | IEEE Transactions on Electron Devices2007，54，3： | 1 |
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