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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Treatment of cerebral vasospasm with biocompatible controlled-release systems for intraeranial drug delivery 显示文摘 | Omeis I Neil J A Murali R Abrahams J M | 2008 | Neurosurgery2008，63，6： | 1 |
| 4 | Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine显示文摘 | O'NEIL M M KENNEDY C A BARTON R W | 2001 | Gene Therapy2001，，8： | 1 |
| 5 | UKPDS 59: hyperglycemia and other potentially modifiable risk factors for peripheral vascular dis- ease in type 2 diabetes显示文摘 | Adler AI Stevens R J Neil A | 2002 | Diabetes Care2002，25，： | 1 |
| 6 | Oxygen isotope fractionation between synthetic aragonite and water: Influence of temperature and Mg2 concentration 显示文摘 | KIM S T O' NEIL J R HILLAIRE-MARCEL C MUCCI A | 2007 | Geochimica Et Cosmochimica Acta2007，71，19： | 1 |
| 7 | Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS:23)显示文摘 | Turner R C Millns H Neil H A W | 1998 | BMJ1998，318，： | 1 |
| 8 | Simultaneous nitrification and denitrification in aerobic chemostat cultures of Thiosphaera pantotroph Appl显示文摘 | ROBERTSON L A VAN NEIL E W J TORREMANS R A M | 1988 | Environ Mcrobiol1988，54，11： | 1 |
| 9 | Hydrogen peroxide and nitric oxide as signaling molecules in plants 显示文摘 | NEIL S J DESIKAN R CLARKE A | 2002 | Journal of Experimental Botany2002，53，： | 1 |
| 10 | Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials显示文摘 | Rod S Taylor Allan Brown Shah Ebrahim Judith Jolliffe Hussein Noorani Karen Rees Becky Skidmore James A Stone David R Thompson Neil Oldridge | 2004 | The American Journal of Medicine2004，，10： | 1 |
| 11 | Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23)显示文摘 | Turner R C Millns H Neil H A | 1998 | BMJ1998，316，7134： | 1 |
| 12 | Effects of microbial activity on theδ18O of dissolved inorganic phosphate and textural features of synthetic apatite显示文摘 | Blake R E O'Neil J R Garacia G A | 1998 | American Mineralogist1998，83，11122： | 1 |
| 13 | Risk factors for coronary artery disease in non - insulin dependent diabetes mellitus(UKP DS: 23) 显示文摘 | TUmer R C Millns H Neil H A | 1998 | Brit Med J1998，316，： | 1 |
| 14 | Biogeochemical cycling of phosphorus:insights from oxygen isotope effects of phosphoenzymes显示文摘 | Blake R E O'Neil J R Surkov A | 2005 | American Journal of Science2005，305，68： | 1 |
| 15 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 16 | A semi-automated method for mapping glacial geomorphology tested at Brei amerkurj kull,Iceland显示文摘 | CIARAN R LAN W NEIL A | 2015 | Remote Sensing of Environment2015，163，： | 1 |
| 17 | Gastrointestinal symptoms in patients with end-stage renal disease undergoing treatment by hemodialysis or peritoneal dialysis 显示文摘 | Cano A E Neil A K Kang J Y Barnabas A Eastwood J B Nelson S R | 2007 | Am J Gastroenterol2007，102，： | 1 |
| 18 | The carotenoid and abscisic acid content of viviparous kernels and seedings of Zea mays 显示文摘 | Neil S J Horgan R Parry A D | 1989 | Planta1989，169，： | 1 |
| 19 | Working area and angle of attack in three cranial base approaches: Pterional, orbitozygomatic, and maxillary extension of the orbitozygomatic approach显示文摘 | L Fernanso Gonzalez Neil R Crawford Michael A Horgan | 2002 | Neurosurgery2002，50，3： | 1 |
| 20 | Type of Vascular Access and Survival among Incident Hemodialysis Patients: The Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study显示文摘 | Brad C A Joseph A E Neil R P | 2005 | J Am Soc Nephrol2005，16，5： | 1 |
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