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| 1 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020,7,2: | 10 |
| 2 | Dyslipidemia management in primary prevention of cardiovascular disease:Current guidelines and strategies显示文摘Cardiovascular disease is the leading cause of death in the United States. In 2010, the Centers for Disease Control and Prevention estimated that $444 billion was spent on cardiovascular diseases alone, about $1 of every $6 spent on health care. As life expectancy continues to increase, this annual cost will also increase, making costeffective primary prevention of cardiovascular disease highly desirable. Because of its role in development of atherosclerosis and clinical events, dyslipidemia management is a high priority in cardiovascular prevention. Multiple major dyslipidemia guidelines have been published around the world recently, four of them by independent organizations in the United States alone. They share the goal of providing clinical guidance on optimal dyslipidemia management, but guidelines differ in their emphasis on pharmacotherapy, stratification of groups, emphasis on lifestyle modification, and use of a fixed target or percentage reduction in low density lipoprotein cholesterol. This review summarizes eight major guidelines for dyslipidemia management and considers the basis for their recommendations. Our primary aim is to enhance understanding of dyslipidemia management guidelines in patient care for primary prevention of future cardiovascular risk. | Aditya D Hendrani Tolulope Adesiyun Renato Quispe Steven R Jones Neil J Stone Roger S Blumenthal Seth S Martin | 2016 | World Journal of Cardiology2016,8,2: | 5 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017,17,27: | 3 |
| 4 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004,7,5: | 2 |
| 5 | Treatment of cerebral vasospasm with biocompatible controlled-release systems for intraeranial drug delivery 显示文摘 | Omeis I Neil J A Murali R Abrahams J M | 2008 | Neurosurgery2008,63,6: | 1 |
| 6 | Oxygen isotope fractionation divalent metal carbonates显示文摘 | O'Neil J R Clayton R N Mayada T K | 1969 | Chemistry Geophysics1969,51,: | 1 |
| 7 | The value of the world’s ecosystemservices and natural capita1显示文摘 | Costanza R Arge R Groot R Farberk S Grasso M HannonB Limburg K Naeem S O’Neil R Paruelo J Raskin R Suttonkk P &Belt M | 1997 | Nature1997,387,: | 1 |
| 8 | Oxygen iso- tope fractionation between synthetic aragonite and water: in-fluence of temperature and Mgz+ concentration显示文摘 | Kim S-T O'Neil J R Hillaire-Mareel C | 2007 | Geochimica et Cosmochimica Acta2007,71,: | 1 |
| 9 | UKPDS 59: hyperglycemia and other potentially modifiable risk factors for peripheral vascular dis- ease in type 2 diabetes显示文摘 | Adler AI Stevens R J Neil A | 2002 | Diabetes Care2002,25,: | 1 |
| 10 | Temkin vacuum electronics high power terahertz sources 显示文摘 | John H Booske Richard J Dobbs Colin D Joye Carol L Kory George R Neil Gunn-sik Park Jaehun Park Richard J | 2011 | IEEE transactions on terahertz science and technolo- gy2011,1,1: | 1 |
| 11 | Mercury concentration in coal-unraveling the puzzle 显示文摘 | TOOLE-O NEIL B TEWALT S J FINKELMAN R B | 1999 | Fuel1999,78,: | 1 |
| 12 | Mercury concentration in coal-unraveling the puzzle显示文摘 | Toole-O'Neil B Tewalt S J Finkelman R B | 1999 | Fuel1999,78,1: | 1 |
| 13 | Oxygen isotope fractionation between synthetic aragonite and water: Influence of temperature and Mg2 concentration 显示文摘 | KIM S T O' NEIL J R HILLAIRE-MARCEL C MUCCI A | 2007 | Geochimica Et Cosmochimica Acta2007,71,19: | 1 |
| 14 | A comparison be tween the high temperature electrode/electrolyte reactions of LixCoO2 and LixMn2O4显示文摘 | Hatchaid T D Dahn J R | 2001 | J Electrochem Soc2001,148,7: | 1 |
| 15 | Oxygen isotope exchange between quartz and water 显示文摘 | Clayton R N O'Neil J R Mayeda T K | 1972 | Journal of Geophysical Research1972,77,: | 1 |
| 16 | Midcourse space experiment: introduction to the spacecraft, instruments, and scientific objectives 显示文摘 | Mill J D O'Neil R R Price S | 1994 | Journal of Spacecraft and Rockets1994,31,5: | 1 |
| 17 | Indices of landscape pattern显示文摘 | Krummel J R | 1988 | Landscape Ecology1988,1,: | 1 |
| 18 | Oxygen isotope exchange between quartz and water 显示文摘 | Clayton R N O'Neil J R Mayeda T K | 1972 | Journal of Geophysical Research1972,77,: | 1 |
| 19 | Dissociation of oceanic methane hydrate as a cause of the carbon isotope ezcursion at the end of the Paleocene显示文摘 | Dickens G R O'Neil J R Rea D K | 1995 | Paleoceanography1995,10,: | 1 |
| 20 | Soybean aphid pred- ators and their use in integrated pest management 显示文摘 | Rutledge C E O'Neil R J Fox T B | 2004 | Ann En- tomol Soc Am2004,97,: | 1 |