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| 1 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 2 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 3 | In situ monitoring of intrinsic stress changes during copper electrodepotion on Au (III)显示文摘 | Haiss W Nichols R J Sass J K | 1997 | Surface Science1997，338，： | 2 |
| 4 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 5 | Design of a modular UHV AC outdoor test system显示文摘 | JAMES R Booker DAVID K Nichols WILLIAM Larzelere | 1983 | IEEE Transactions on Power Apparatus and System1983，102，8： | 1 |
| 6 | Nonoperative treatment of traumatic pancreatic duct disruption using an endoscopically placed stent 显示文摘 | Age C Nichols K | 1996 | J Trauma1996，41，： | 1 |
| 7 | Experimental vesicular stomatitis virus infection of swine: extent of infection immunological response 显示文摘 | Nichol S Klieforth R | 1989 | Vet Immunol Immunopathol1989，20，2： | 1 |
| 8 | Cryplosporidium:Detection in water and food显示文摘 | Smith H V Nichols R | 2009 | Expermental Parasitology2009，123，4： | 1 |
| 9 | Nitrogen and phosphorus release from decaying water milfoil显示文摘 | NICHOLE D S KEENEY D R | 1973 | Hydrobiologia1973，42，： | 1 |
| 10 | Separation of Eperythrozoon ovis from erythrocytes显示文摘 | Lang F M Ferrier G R Nicholls T J | 1986 | Vet Rec1986，119，： | 1 |
| 11 | Plasma N-terminal pro-brain natriuretic peptide anddrenomedullin: prognosticutility and prediction of benefit from carvedilol in chronic ischaemic left ventricular dysfunction显示文摘 | Richards AM Doughty R Nicholls MG | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 12 | Realising new leisure opportunities for old urban parks: the internal reserve in Australia 显示文摘 | Freestone R Nichols D | 2004 | Landscape and Urban Planning2004，68，1： | 1 |
| 13 | Bile peritonitis after removeal of T --tube from the common bile duct显示文摘 | Corbett C R Fyfe N C Nicholls R J etal | 1986 | Br J Surg1986，73，64： | 1 |
| 14 | Comparative safety and immunogenicity of two yellow fever 17D vaccines(ARILVAX and YF-VAX)in a phase III multicenter,doubleblind clinical trial显示文摘 | Monath TP Nichols R Archambault WT | 2002 | Am J Trop Med Hyg2002，66，5： | 1 |
| 15 | A comparisonbetween the erosion behaviour of thermal spray andelectron beam physical vapour deposition thermal barriercoatings显示文摘 | Nicholls J R Deakin M J Rickerby D S | 1999 | Wear1999，，233235： | 1 |
| 16 | Resilience to natural hazards: how useful is this concept 显示文摘 | Klein R J T Nicholls R J Thomalla F | 2003 | Global Environmental Change Part B: Environmental Hazards2003，5，12： | 1 |
| 17 | Testing and commissioning of a modular UHV AC outdoor test system显示文摘 | DAVID K Nichols JAMES R Booker WILLIAM Larzelere | 1984 | IEEE Transactions on Power Apparatus and Sys tem1984，103，7： | 1 |
| 18 | Swine manure characterization as affected by environmental-temperature, dietary level intake, and dietary-fat addition显示文摘 | Clanton C J Nichols D A Moser R L | 1991 | Transactions of the ASAE1991，34，： | 1 |
| 19 | Lagoon subsidence and tsunami on the West Coast of New Zealand 显示文摘 | Nichol S L Goff J R Devoy R J N | 2007 | Sedimentary Geology2007，200，： | 1 |
| 20 | Obliteration offemoral artery pseudoaneurysm by thrombin injection 显示文摘 | Edgerton J R Moore DO Nichols D | 2002 | Ann Thorac Surg2002，74，4： | 1 |
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