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	题名	作者	年代	出处	被引量
1	Expression of β-catenin in hepatocellular carcinoma显示文摘AIM: The β-catenin has been recognized as a critical member of the Wnt signaling pathway and plays an important role in the generation/differentiation of many tissues. Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as its prognosis of hepatocellular carcinoma (HCC) has remained unclear. The purpose of this study is to analyze the expression of β-catenin in HCC in relation to histological grades and viral hepatitis backgrounds.METHODS: Thirty-two sections were selected at random from autopsy and surgical cases of HCC. Immuohistologically,the location and positivity of β-catenin expression in HCC was examined.RESULTS: Normal hepatocytes did not express β-catenin.In 78% of HCC β-catenin was expressed at the membrane of the cells, with or without cytoplasmic and/or nuclear expression. The tumor cells with well- and moderatelydifferentiated grades expressed frequently at the membrane and cytoplasm compared with poorly-differentiated type.Nuclear expression of β-catenin was prone to occur in the tumor cells of poorly-differentiated grade. There were 15% of hepatitis C virus (HCV) backgrounds with nuclear expression. In contrast, there was 38% with nuclear expression in hepatitis B virus (HBV) backgrounds. In nonBnonC hepatitis, no case expressed nuclear β-catenin.CONCLUSION: The β-catenin expression in HCC cells was heterogenous among types of hepatitis viral infection.Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background.	Liem Thanh Tien Masahiro Ito Mikiko Nakao Daisuke Niino Meirmanov Serik Masahiro Nakashima Chun-Yang Wen Hiroshi Yatsuhashi Hiromi Ishibashi	2005	World Journal of Gastroenterology2005，11，16：	8
2	Generation of protein crystals using a solution-stirring technique显示文摘	Adaehi H Niino A Matsumura H	2004	Jpn J Appl Phys Part 2-Lett & Express Lett2004，43，6：	1
3	The increasing cesarean rate globally and what we can do about it显示文摘	Yoshiko Niino	2011	BioScience Trends2011，5，4：	1
4	Rotational feedthrough using ultrasonic motor for high vacuum condition显示文摘	Morita T Niino T Asama H	2002	Vacuum2002，65，：	1
5	Solution-stirring method improves crystal quality of human triosephosphate isomerase显示文摘	Adachi H Niino A Kinoshita T	2006	J Biosc Bioeng2006，101，1：	1
6	Newly developed encapsulation- dehydration protocol for plant eryopreservation 显示文摘	Sakai A Matsumoto T Hirai D Niino T	2000	Cryoletters2000，21，1：	1
7	C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis显示文摘	Miyagishi R Niino M Fukazawa T	2003	J Neuroimmunol2003，145，12：	1
8	Long-term conservation of Diospyros germplasm using dormant buds by a prefreezing method 显示文摘	Matsumoto T Kurahashi T Niino T	2004	Plant Biotechnol2004，21，：	1
9	Two-dimensional mapping of fine structures in the Kuroshio Current using seismic reflection data显示文摘	Tsuji T Noguchi T Niino H	2005	Geophysical Research Letters2005，32，14：	1
10	Prognosis for patients with type B acute aortic dissection: risk analysis of early death and requirement for elective surgery显示文摘	Hata M Sezai A Niino T	2007	Circ J2007，71，8：	1
11	Multiple polar meso cyclones over the Japan sea on ll February 1997显示文摘	Fu Gang Hiroshi Niino Ryuii Kimura	2004	Mon Wea Rev2004，132，3：	1
12	Growth of a composite function of entire functions显示文摘	Niino K Suita N	1980	Kodai Math J1980，3，：	1
13	HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands 显示文摘	Kikuchi S Fukazawa T Niino M	2003	Neurology2003，60，：	1
14	A semiautomatic protein crystallization system with preventing evaporation of drops and surface sensor of solution显示文摘	Adachi Hiroaki Takano Kazufumi Matsumura Hiroyoshi Niino	2004	Japanese Journal of Applied Physics Part 2 : Letters2004，43，1：	1
15	Effects of logging road networks on the ecological functions of dung beetles in Peninsular Malaysia显示文摘	TetsuroHosaka Masahiro Niino Masahiro Kon Teruo Ochi Toshihiro Yamada Christine Fletcher Toshinori Okuda	2014	Forest Ecology and Management2014，326，：	1
16	Clinical significance of CD163( + ) tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma显示文摘	Komohara Y Niino D Saito Y	2013	Cancer Sci2013，104，7：	1
17	Multiple LED photographic curing of models for design verification 显示文摘	Kai Loose Toshiki Niino and Takeo Nakagawa	1999	Rapid Prototyping Journal1999，5，1：	1
18	Estrogen receptor gene polymorphism in Japanese patients with multiple sclerosis 显示文摘	Niino M Kikuchi S Fukazawa T	2000	J Neurol Sci2000，179，12：	1
19	Prognosis for patients withtype B acute aortic dissection:risk analysis of early death andrequirement for elective surgery显示文摘	Hata M Sezai A Niino T	2007	Circ J2007，71，8：	1
20	Ca2 + influx through P2X re- ceptors induces aetin eytoskeleton reorganization by the formation of eofilin rods in neuritis 显示文摘	Homma K Niino Y Hotta K	2007	Mol Cell Neurosei2007，37，：	1

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