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| 1 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 2 | Gene expression profilesand structural/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles 显示文摘 | Mirkin S Nikas G Hsiu JG | 2004 | J Clin Endocrinol Metab2004，89，： | 1 |
| 3 | Dimensional crossover of thermal transport in few-layer graphene显示文摘 | Ghosh S Bao W Nika D L | 2010 | Nature Materials2010，9，： | 1 |
| 4 | Multi-walled carbon nanotubes induce T lymphocyte apoptosis显示文摘 | Bottini M Bruckner S Nika K | 2006 | Toxicol Lett2006，160，： | 1 |
| 5 | The effect of Weber number on the central binary collision outcome between unequal-sized droplets显示文摘 | Nikolopoulos N Strotos G Nikas K S | 2012 | Interna- ~ional Journal of Heat and Mass Transfer2012，55，： | 1 |
| 6 | Biochemical analysis of the e IF2βγcomplex reveals a structural function for e IF2αin catalyzed nucleotide exchange显示文摘 | Nika J Rippel S Hannig E M | 2001 | J Biol Chem2001，276，2： | 1 |
| 7 | A functional variant of lymphoid tyrosine phosphatase is associated with type Ⅰ diabetes显示文摘 | Bottini N Musumeci L Alonso A Rahmouni S Nika K Rostamkhani M | 2004 | Nat Genet2004，36，： | 1 |
| 8 | Numerical simulation of the flow and the collection mechanisms inside a laboratory scale electrostatic precipitator显示文摘 | Nikas K S P Varonos A A Bergeles G C | 2005 | Journal of Electrostatics2005，63，5： | 1 |
| 9 | Multi-walled carbon nanotubes induce T lymphocyte apoptosis显示文摘 | Bottini M Bruckner S Nika K Bottini N Bellucci S Magrini A | 2006 | Toxicol Lett2006，160，： | 1 |
| 10 | Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease显示文摘AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative recurrence.METHODS Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.910, P = 0.043) were also predictors of postoperative recurrence. No association was revealed between postoperative recurrence and smoking status, postoperative prophylactic treatment and the presence of myenteric plexitis and relapse.CONCLUSION The presence of severe submucosal plexitis with lymphocytes in the proximal resection margin is more likely to result in postoperative relapse in CD. | Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás Molnár | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 1 |
| 11 | Effects of Irbesartan/diuretic combination treatment on serum uric acid levels in hypertensive patients显示文摘 | MIBIONIS H J NIKAS S ELISAF M S | 2001 | Am J Caodiol2001，88，9： | 1 |
| 12 | Effects of debris particles in sliding/rolling elastohydrodynamic contacts 显示文摘 | Nikas G K Sayles R S Ioannides E | 1998 | Proceedings of the Institution of Mechanical Engineers1998，212，5： | 1 |
| 13 | A numerical investigation of central binary collision of droplets 显示文摘 | Nikolopoulos N Nikas K S Bergeles G | 2009 | Computers & Fluids2009，38，： | 1 |
| 14 | PhononThermal Conduction in Graphene: Role of Umklapp andEdge Roughness Scattering 显示文摘 | Nika D L Pokatilov E P Askerov A S | 2009 | Phys Rev B2009，79，15： | 1 |
| 15 | Multi-welled carbon nanotubes induce T lymphocyte apoptosis显示文摘 | BOTTINI M BRUCKNER S NIKA K el al | 2006 | Toxicology Letters2006，160，2： | 1 |
| 16 | Modelling and optimization of composite rectangular reciprocating seals显示文摘 | Nikas G K Sayles R S | 2006 | Proc IMechE Part J:J Engineering Tribology2006，220，4： | 1 |
| 17 | Multiwalled carbon nanotubes induce T lymphocyte apoptosis显示文摘 | BOTTINI M BRUCKNER S NIKA K | 2006 | Toxiol Lett2006，160，2： | 1 |
| 18 | Multi-walled carbon nanotubes induce T lymphocyte apoptosis 显示文摘 | Bottini M Bruekner S Nika K | 2006 | Toxieol Lett2006，160，2： | 1 |
| 19 | Numerical simu lation of the flow and the collection mechanisms inside a labo ratory scale electrostatic preclpitator显示文摘 | Nikas K S P Varonos A A Bergeles G C | 2005 | Journal of Electro statics2005，63，5： | 1 |
| 20 | Study of leakage and friction of flexible seals for steady motion via a numerical approximation method显示文摘 | Nikas G K Saylss R S | 2006 | Tribol Int2006，39，9： | 1 |
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