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| 1 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 2 | J Phys Chem B显示文摘 | Nikolai Gaponik Talapin D V Rogach A L | 2002 | 106:7 1772002，106，： | 1 |
| 3 | Tumor-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells显示文摘 | Nikolai NK Jianqing Y Edwardine L | 2003 | J Cell Sci2003，116，6： | 1 |
| 4 | Monitoring ultrathin film photopoly- merization of tetra-alkylepoxyporphyrin by UV-Vis spectroscopy显示文摘 | Kalle L Linda S Alexander E Sami H Risto A Nikolai T Helge L | 2009 | Journal of Polymer Science Part A: Polymer Chemistry2009，47，22： | 1 |
| 5 | Lightning activity related to satellite and radar observations of a mesocale con- vective system over Texas on 7 - 8 April 2002 显示文摘 | Nikolai D Rabin R M Carey L D | 2005 | Atmos- pheric Research2005，76，： | 1 |
| 6 | A Comparison of Published Accounting Research and Qualities of Accounting Faculty and doctoral programs 显示文摘 | BAZLEY J D NIKOLAI L A | 1975 | The Accounting Review1975，，6： | 1 |
| 7 | Customer- specific adaptation by providers and their perception of 3PL-relationship success 显示文摘 | RUDOLF O L NIKOLAI K RAHEL K H | 2011 | International Journal of Physical Distribution & Logistics Management2011，41，9： | 1 |
| 8 | Tumor-endothelium interactions in co-culture:coordinated changes of gene expression profiles and phenotypic properties of endothelial cells显示文摘 | Nikolai NK Jianqing Y Edwardine L | 2003 | J Cell Sci2003，116，6： | 1 |
| 9 | Lightning activity related to satellite and radar observations of a mesoscale convective system over Texas on 7 - 8 April 2002 显示文摘 | Nikolai D Rabin R M Carey L D | 2005 | Atmospheric Research2005，76，： | 1 |
| 10 | Synthesis and reactions of 1, 1- diamino-2, 2-dinitroethylene 显示文摘 | Nikolai V L Jan Bergman | 1998 | Tetrahedron1998，54，11： | 1 |
| 11 | Toward efficient blue-emitting thiol-capped ZnI - Cd Se nanocrystals 显示文摘 | Vladimir L Alexei P Nikolai G | 2008 | Journal of Materials Chemistry2008，18，42： | 1 |
| 12 | Plasma opening switch with isolation by extrinsic magnetic field 显示文摘 | GEORGI L D NIKOLAI B DAMITRI D | 2002 | IEEE Transactions on Pulsed Power Plasma Science2002，2，2： | 1 |
| 13 | Local maternal control of seed size by KLUH/CYP78A5-dependent growth signaling显示文摘 | Nikolai M Adamskia ElenaA Sven E Carmel M O'Neillc Michael L | | 0，，： | 1 |
| 14 | Stability of the aqueous suspensions of nanotubes in lhe presence of nonionic surfactant显示文摘 | Milana O L Nikolai I L Olexander V M | 2006 | Colloid Interface Sci2006，299，： | 1 |
| 15 | STAT1 is Overexpressed in Tumors Selected for Radioresistance and Confers Protection from Radiation in Transduced Sensitive Cells显示文摘 | NIKOLAI NK MICHAEL B EDWARDINE L THOMAS D BERNARD R RALPH R W | 2004 | Proc Natl Acad Sci U S A2004，101，6： | 1 |
| 16 | Tumor-endothelium interactions in co-culture:coordinated changes of gene expression profiles and phenotypic properties of endothelial cells显示文摘 | Nikolai NK Jianqing Y Edwardine L | 2003 | J Cell Sci2003，116，6： | 1 |
| 17 | Digital Communication Using Chaotic - Pulse - Position Modulation 显示文摘 | NIKOLAI F MIKHIAIL M SUSHCHIK L S | 2001 | IEEE Transactions and Systems2001，48，12： | 1 |
| 18 | Assessment of molecular structure using frame-independent orientational restraints derived from residual dipolar couplings显示文摘 | Nikolai R Skrynnikov N R Kay L E | 2000 | J Biomol NMR2000，18，： | 1 |
| 19 | Frequency Converters in Water Supply Syste-ms for Energy Saving显示文摘 | Nikolai l | | 0，，05： | 1 |
| 20 | Tumor-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells 显示文摘 | Nikolai NK Jianqing Y Edwardine L | 2003 | J Cell Sci2003，116，6： | 1 |
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