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| 1 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 2 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 3 | Dynamics and control of a tethered flight vehi cle显示文摘 | No T S Jr C J E | 1995 | Journal of Guidance Control and Dynamics1995，18，1： | 1 |
| 4 | Hyperopic shift in refraction associated with implanta- tion of the single-piece Collatner intra-ocular lens 显示文摘 | SANDERS DR HIGGI RW OPATOWSKY IE CONFI- NO J | 2005 | J Cataract Refract Surg2005，32，12： | 1 |
| 5 | Hematogenous spreading of hepatocellular careinoma cells:possible participation in recurrence in the liver显示文摘 | Funaki NO Tanaka J Seto SI | 1997 | Hepatology1997，25，5： | 1 |
| 6 | Fabrication of PZT Thick Films on silicon Substrates for Piezoelectric Actuator显示文摘 | Jeon Y Chung J NO K | 2000 | Journal of Electroceramics2000，41，： | 1 |
| 7 | Hereditary thrombophilia in Korean patients with idiopathic pulmonary embolism显示文摘 | LEE M NO H J JANG S Y | 2012 | Yonsei Med J2012，53，： | 1 |
| 8 | Trace representation of legendre sequences mersenne prime period显示文摘 | No J S Lee H K | 1996 | IEEE Trans Inform Theory1996，42，11： | 1 |
| 9 | Hydrogen production by ethanol steam reforming over Cu-Ni supported catalysts显示文摘 | Vizcaíno A J Carrero A Calles J A | 2007 | Int J Hydrogen Energy2007，32，： | 1 |
| 10 | The expression of p53, bcl-2, bax, fas and fasL in the primary turnout and lymph node metastases of breast cancer 显示文摘 | Sjostrim-Mattson J Von Boguslawski K Bengtsson NO | 2009 | Acta Oncol2009，48，8： | 1 |
| 11 | New construction of quaternary sequences with good correlation using binary sequences with good correlation显示文摘 | Lira T No J S and Chung H | 2011 | IEICE Transactions on Fundamentals of Electronics Communications and Computer Sciences2011，94，8： | 1 |
| 12 | Endoscopic approach to pancreatic pseudocyst abscess and necrosis: review on recent progress 显示文摘 | CHEN J FUKAMI NO LI ZS | 2012 | Dig Endosc2012，24，5： | 1 |
| 13 | A dry-spot model of critical heat flux in pool and forced convection boiling显示文摘 | NO H C | 1998 | Int J Heat Mass Transfer1998，41，2： | 1 |
| 14 | A new family of binary pseudorandom sequences having optimal periodic correlation properties and large linear span显示文摘 | No J S Kumar P V | 1989 | IEEE Trans Inform Theory1989，35，2： | 1 |
| 15 | A modified SLM scheme with low complexity for PAPR reduction of OFDM systems显示文摘 | HEO S J NOH H S NO J S | 2007 | IEEE Transactions on Broadcast-ing2007，53，4： | 1 |
| 16 | Development of a flowsheet for iodine-sulfur thermo-ehemical cycle based on optimized Bunsen reaction 显示文摘 | Lee B J No H C Yoon H J | 2009 | International Journal of Hydrogen Energy2009，34，5： | 1 |
| 17 | ASIC3,a sensor of acidic and primary inflammatory pain显示文摘 | Deval E Nol J Lay N | 2008 | EMBO J2008，27，22： | 1 |
| 18 | A modified SLM scheme with low complexity for PAPR reduction of OFDM systems显示文摘 | HEO S J NOH H S NO J S | 2007 | IEEE Transactions on Broadcasting2007，53，4： | 1 |
| 19 | Improvement in demand-controlled ventilation simulation on multi-purposed facilities under an occupant based ventilation standard 显示文摘 | JEONG J W CHOI A NO S T | 2010 | Simulation Modelling Practice and Theory2010，18，1： | 1 |
| 20 | Nitrogen digestion and metabolism in sheep consuming diets containing contrasting forms and levels of nitrogen显示文摘 | Siddons R E No lan J V Boever D E | 1985 | British Journal of Nutrition1985，54，： | 1 |
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