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| 1 | Predictors of dehydration and acute renal failure in patients with diverting loop ileostomy creation after colorectal surgery显示文摘BACKGROUND Despite the potential benefits of fecal diversion after low pelvic anastomosis in colorectal surgery, diverting loop ileostomy construction is related to significant rates of complications. AIM To determine potential predictors of high output related complications in patients with diverting loop ileostomy creation after colorectal surgery. METHODS Patients who underwent open and laparoscopic colorectal surgery requiring a diverting loop ileostomy from January 2010 to March 2018 were retrospectively analyzed. We included patients older than 18 years, who underwent colorectal surgery with primary low pelvic anastomosis, and with the creation of a diverting loop ileostomy, at elective or emergency settings for the treatment of benign or malignant conditions. Univariate and multivariate logistic regression analysis was used to determine the effect of the potential predictors on the rate of high output related complications. The high output related complications were dehydration and acute renal failure that required visits to the emergency department and hospitalizations. RESULTS Of the 102 patients included in the study, 23.5%(n = 24) suffered high output related complications. In this group of patients at least one visit to the emergency department (mean 1.6), and at least one readmission to the hospital was needed. The factors associated with high-output ileostomy, in the univariate analysis, were: urgent surgical intervention (OR = 2.6;P = 0.047), the development of postoperative complications (OR = 3;P = 0.024), have ulcerative colitis (OR = 4.8;P = 0.017), use of steroids (OR = 4.3;P = 0.010), mean output at discharge greater than 1000 mL/24 h (OR = 3.2;P = 0.016), and use of loperamide at discharge (OR = 2.8;P = 0.032). Multivariate logistic regression analysis identified two independent risk factors for high output related complications: ulcerative colitis [OR = 7.6 (95%CI: 1.81-31.95);P = 0.006], and ileostomy output at discharge ≥ 1000 mL/24 h [OR = 3.3 (1.18-9.37);P = 0.023]. CONCLUSION In our study, patients with ulcerative colitis and those with an ileostomy output above 1000 mL/24 h at discharge, were at increased risk of high output related complications. | Omar Vergara-Fernández Mario Trejo-Avila Oscar Santes Danilo Solórzano-Vicu?a Noel Salgado-Nesme | 2019 | World Journal of Clinical Cases2019，7，14： | 2 |
| 2 | Acute kidney injury and electrolyte disorders in COVID-19显示文摘Acute kidney injury(AKI)and electrolyte disorders are important complications of hospitalized coronavirus disease 2019(COVID-19)patients.AKI is thought to occur due to multiple pathophysiological mechanisms,such as multiple organ dysfunction(mainly cardiac and respiratory),direct viral entry in the renal tubules,and cytokine release syndrome.AKI is present in approximately one in every ten hospitalized COVID-19 patients.The incidence rates of AKI increase in patients who are admitted to the intensive care unit(ICU),with levels higher than 50%.Additionally,renal replacement therapy(RRT)is used in 7%of all AKI cases,but in nearly 20%of patients admitted to an ICU.COVID-19 patients with AKI are considered moderate-to-severe cases and are managed with multiple interdisciplinary conducts.AKI acts as a risk factor for mortality in severe acute respiratory syndrome coronavirus 2 infection,especially when RRT is needed.Electrolyte disorders are also common manifestations in hospitalized COVID-19 patients,mainly hyponatremia,hypokalemia,and hypocalcemia.Hyponatremia occurs due to a combination of syndrome of inappropriate secretion of antidiuretic hormone and gastrointestinal fluid loss from vomiting and diarrhea.When it comes to hypokalemia,its mechanism is not fully understood but may derive from hyperaldosteronism due to renin angiotensin aldosterone system overstimulation and gastrointestinal fluid loss as well.The clinical features of hypokalemia in COVID-19 are similar to those in other conditions.Hypocalcemia is the most common electrolyte disorder in COVID-19 and seems to occur because of vitamin D deficiency and parathyroid imbalance.It is also highly associated with longer hospital and ICU stay. | Gabriel Martins Nogueira Noel Lucas Oliveira Rodrigues Silva Ana Flávia Moura Marcelo Augusto Duarte Silveira JoséA Moura-Neto | 2022 | World Journal of Virology2022，11，5： | 2 |
| 3 | Ovine pla- cental laetogen specifically binds to endometrial glands of the ovine uterus 显示文摘 | NOEL S HERMAN A JOHNSON G A | 2003 | Biol Reprod2003，68，： | 1 |
| 4 | Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies显示文摘 | Servais A Noel LH Roumenina LT | 2012 | Kidney Int2012，82，4： | 1 |
| 5 | Influence of environmen- tal Vertical wind shear on the intensity of hurricanne-strength tropical cyclones in the Australian region显示文摘 | Linda A P Barry N H Noel E D | 2005 | Mon Wea Rev2005，133，： | 1 |
| 6 | Assay of matrix metalloproteinases types 1,2,3 and 9 in breast cancer显示文摘 | Remacle AG Noel A Duggan C | | 0，，06： | 1 |
| 7 | Delivery of nficro- RNA-126 by apoptotic bodies induces CXCL12-dependent vascu- lar protection 显示文摘 | Zemecke A 13idzhekov K Noels H | 2009 | Sci Signal2009，2，100： | 1 |
| 8 | Learning Spanish as a second language:Learners'orientations and perceptions of their teachers'communicationstyle显示文摘 | NOELS K A | 2001 | Language Learning2001，51，1： | 1 |
| 9 | Anatomically accurate,finite model eye for optical modeling显示文摘 | Liou Hwey-Lan Brennan Noel A | 1997 | J Opt Soc Am A1997，14，8： | 1 |
| 10 | Reduction of apoptosis and proliferation in endometriosis显示文摘 | Beliard A Noel A Foidart JM | 2004 | Fertil Steril2004，82，1： | 1 |
| 11 | Membrane type-matrix metalloproteinases and tumor progression 显示文摘 | Sounni NE Noel A | 2005 | Biochimie2005，87，34： | 1 |
| 12 | New computerized color image analysis for the quantification of interstitial fibrosis in renal transplantation显示文摘 | Meas-Yedid V Servais A Noel LH | | 0，，： | 1 |
| 13 | Scedosporium apiosper- mum otitis complicated by a Temporomandibular arthritis: A case report and mini-review显示文摘 | Huguenin A Noel V Rogez A | 2015 | Mycopathologia2015，，： | 1 |
| 14 | Matrix metalloproteinase-9 contributes to choroidal neovascularization 显示文摘 | LAMBERT V MUNAUT C JOST M NOEL A WERB Z FOI- DART JM | 2002 | Am J Pathol2002，161，4： | 1 |
| 15 | Updated Kiel classification for lymphomas显示文摘 | Diebold J Noel H | 1988 | Lancet1988，1，： | 1 |
| 16 | Kinetic aspects of the glass transition behavior of maltose-water mixtures显示文摘 | Noel T R Riny S G Whittam M A | 1991 | Carbohydrates Research1991，，212： | 1 |
| 17 | Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow显示文摘 | Noel T Musacchio A J | 2011 | Org Lett2011，13，： | 1 |
| 18 | Bactericidal activity of multiple combinations of tigecycline and eolistin against NDM-l-producing Enterobacteriaceae 显示文摘 | Albur M Noel A Bowker K | 2012 | Antimicrob Agents Chemother2012，56，6： | 1 |
| 19 | Delivery of microRNA-126 by apoptotic bodies induces CXCL12-depend-ent vascular protection显示文摘 | Zernecke A Bidzhekov K Noels H | | 0，，100： | 1 |
| 20 | Cloning of choriocarcinoma cells shows that invasion correlates with expression and Activation of Gelatinase A显示文摘 | Crescimanno C Foidart JM Noel A | 1996 | Exp Cell Res1996，227，2： | 1 |
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