|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Expression transforming growth factor-βeta isoforms in human glomerular disease显示文摘 | YAMAMOTO T NOBLE N A COHEN A H | 1996 | Kidney Int1996，49，2： | 2 |
| 3 | Transforming growth factor beta in tissue fibrosis显示文摘 | BORDER W A NOBLE N A | 1994 | N Engl J Med1994，331，19： | 1 |
| 4 | Targeting TGF-beta overexpression:maximizing the antifibrotic actions of angiotensin Ⅱ blockade in anti-Thy1 glomerulonephritis显示文摘 | PETERS H BORDER W A NOBLE N A | 1999 | Nephrol Dial Transplant1999，14，4： | 1 |
| 5 | Sustained expression of TGF-β显示文摘 | Yamamoto T Noble N Miller DE | | 0，，： | 1 |
| 6 | Transforming growth factor 13 in tissue fibrosis显示文摘 | Border W A Noble N A | 1994 | New Engl J Med1994，331，： | 1 |
| 7 | Three-dimensional shape of the dysplastic femur: implications for THR 显示文摘 | Noble PC Kamaric E Sugano N | 2003 | Clin Orthop Relat Res2003，，417： | 1 |
| 8 | Protein kinase inhibitors:insights into drug design from structure 显示文摘 | Noble M E Endicott J A Johnson L N | 2004 | Science2004，303，5665： | 1 |
| 9 | PTSD and dopaminergic genes, DRD2 and DAT, in muhigenerational families exposed to the Spitak earthquake 显示文摘 | BAILEY J N GOENJIAN A K NOBLE E P | 2010 | Psychiatry Res2010，178，3： | 1 |
| 10 | TGF-β1 a cytokine mediator of glomerulo- sclerosis and a target for therapeutic intervention显示文摘 | LonderW A Noble N A Ketteler M | 1995 | Kidney Int1995，47，49： | 1 |
| 11 | Dextransulfate promotes the rapid aggregation of porcine bone-marrow stromal cells 显示文摘 | Noble BS Dean V Loueridge N | 1995 | Bone1995，17，4： | 1 |
| 12 | Intra-arterialthromboly- sis for central retinal artery occlusion :a systematic review显示文摘 | Noble J Weizblit N Baerlocher MO | 2008 | Br J Ophtralmol2008，92，5： | 1 |
| 13 | Dextransulfate promotes the rapid aggregation of porcine bone-marrow stromal cells 显示文摘 | Noble BS Dean V Loueridge N | 1995 | Bone1995，17，4： | 1 |
| 14 | UK muhicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal translucency thickness at 10 - 14 weeks of ges- tation显示文摘 | Snijders RJM Noble P Sebire N Souka A Nicolaides KH | 1998 | Lancet1998，351，： | 1 |
| 15 | The three- dimensional shape of the dysplastic femur显示文摘 | Noble PC Kamatie E Sugano N | 2003 | Clin Orthop2003，417，： | 1 |
| 16 | Transforming growth factor 13 in tissue fibrosis显示文摘 | Border W A Noble N A | 1994 | New Engl J Med1994，331，： | 1 |
| 17 | The Near-infrared Combination and Frequencies of Dioctahedral Smectites, Micas, and Illites显示文摘 | Post J L Noble P N | 1993 | Clays and Clay Minerals1993，41，6： | 1 |
| 18 | Distinct pbosphorylation sites on the {beta} 2-adrenergic receptor establish a barcode that encodes differential fimctions of {beta}-arrestin显示文摘 | Nobles K N Xiao K Alan S | 2011 | Science signaling2011，4，185： | 1 |
| 19 | Increased expression of transforming growth factor beta isoforms ( beta 1, beta 2, beta 3) in bleomyein-indueed pulmonary fibrosis 显示文摘 | SANTANA A SAXENA B NOBLE N A | 1995 | Am J Respir Cell Mol Biol1995，13，1： | 1 |
| 20 | Antiphospholipid anti- bodies associated with recurrent pregnancy loss: prospective, mul- ticenter, controlled pilot study comparing treatment with low-molec- ular-weight heparin versus unfractionated heparin 显示文摘 | Noble LS Kutteh WH Lashey N | 2005 | Fertil Steril2005，83，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员