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| 1 | High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis显示文摘BACKGROUND The quantitative faecal immunochemical test for haemoglobin(FIT) has been revealed to be highly accurate for colorectal cancer(CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected CRC in low-risk symptomatic patients using a 10 μg Hb/g faeces threshold.Nevertheless, it is unknown whether FIT′s accuracy remains stable throughout the broad spectrum of possible symptoms.AIM To perform a systematic review and meta-analysis to assess FIT accuracy for CRC detection in different clinical settings.METHODS A systematic literature search was performed using MEDLINE and EMBASE databases from inception to May 2018 to conduct a meta-analysis of prospective studies including symptomatic patients that evaluated the diagnostic accuracy of quantitative FIT for CRC detection. Studies were classified on the basis of brand,threshold of faecal haemoglobin concentration for a positive test result,percentage of reported symptoms(solely symptomatic, mixed cohorts) and CRC prevalence(< 2.5%, ≥ 2.5%) to limit heterogeneity and perform subgroup analysis to assess the influence of clinical spectrum on FIT′s accuracy to detect CRC.RESULTS Fifteen cohorts including 13073 patients(CRC prevalence 0.4% to 16.8%) were identified. Pooled estimates of sensitivity for studies using OC-Sensor at 10 μg Hb/g faeces threshold(n = 10400) was 89.6% [95% confidence interval(CI): 82.7%to 94.0%). However, pooled estimates of sensitivity for studies formed solely by symptomatic patients(n = 4035) and mixed cohorts(n = 6365) were 94.1%(95%CI: 90.0% to 96.6%) and 85.5%(95%CI: 76.5% to 91.4%) respectively(P <0.01), while there were no statistically significant differences between pooled sensitivity of studies with CRC prevalence < 2.5%(84.9%, 95%CI: 73.4% to 92.0%)and ≥ 2.5%(91.7%, 95%CI: 83.3% to 96.1%)(P = 0.25). At the same threshold, OCSensor? sensitivity to rule out any significant colonic lesion was 78.6%(95%CI:75.6% to 81.4%). We found substantial heterogeneity especially when assessing specificity.CONCLUSION The results of this meta-analysis confirm that, regardless of CRC prevalence,quantitative FIT is highly sensitive for CRC detection. However, FIT ability to rule out CRC is higher in studies solely including symptomatic patients. | Noel Pin Vieito Sara Zarraqui?os Joaquín Cubiella | 2019 | World Journal of Gastroenterology2019，25，19： | 5 |
| 2 | Community knowledge,attitudes and practices related to schistosomiasis and associated healthcare-seeking behaviours in northern Côte d’Ivoire and southern Mauritania显示文摘Background:Among parasitic infections,schistosomiasis ranks second after malaria in terms of worldwide morbidity.Despite efforts to contain transmission,more than 230 million people are infected,of which 85%live in Sub-Saharan Africa.While the epidemiologic characteristics of schistosomiasis have been extensively studied across endemic settings,social factors have been paid less attention.The current study assesses community knowledge of schistosomiasis causes,transmission,signs,symptoms and prevention,as well as healthcare-seeking behaviours in two West African settings,with the aim of strengthening schistosomiasis control interventions.Methods:From August 2014 to June 2015,we conducted two cross-sectional surveys in Korhogo,Cote d’Ivoire and Kaedi,Mauritania.We applied a questionnaire to collect quantitative data at the household level in Korhogo(n=1456)and Kaedi(n=1453).Focus group discussions(Korhogo:n=32,Kaedi:n=32)and participatory photography(photovoice)(Korhogo:n=16,Kaedi:n=16)were conducted within the communities to gather qualitative data.In addition,semi-structured interviews were used to discuss with key informants from control programmes,nongovernmental organizations and health districts(Korhogo:n=8,Kaedi:n=7).Results:The study demonstrated that schistosomiasis is not well known by the communities;64.1%claimed to know the causes of the disease,but the reality is different.This knowledge is more from cultural than biomedical source.It was observed that social construction of the disease is different from the biomedical definition.In Korhogo,schistosomiasis was often associated with several other diseases,notably stomach ulcer and gonorrhoea.The populations believe that schistosomiasis is caused by exposure to goat or dog urine in the environment.In Kaedi,schistosomiasis is considered as a disease transmitted by environmenal elements such as sunshine and dirty water.In both settings,the care-seeking pathways were found to be strongly influenced by local customs and self-medication acquired from the informal sector.Conclusions:This study revealed that knowledge about the aetiology,transmission,symptoms,prevention and treatment of schistosomiasis among the populations in Korhogo and Kaedi is based on their local culture.Deep-rooted habits could therefore pose a significant obstacle to the elimination of schistosomiasis. | Amoin Jeanne d’Arc Koffi Mohamed Doumbia Gilbert Fokou Moussa Keita Brama Kone N’doumy Noel Abe | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 3 | Faecal immunochemical test outside colorectal cancer screening?显示文摘Faecal immunochemical tests(FITs)are the most widely colorectal cancer(CRC)diagnostic biomarker available.Many population screening programmes are based on this biomarker,with the goal of reducing CRC mortality.Moreover,in recent years,a large amount of evidence has been produced on the use of FIT to detect CRC in patients with abdominal symptoms in primary healthcare as well as in surveillance after adenoma resection.The aim of this review is to highlight the available evidence on these two topics.We will summarize the evidence on diagnostic yield in symptomatic patients with CRC and significant colonic lesion and the different options to use this(thresholds,brands,number of determinations,prediction models and combinations).We will include recommendations on FIT strategies in primary healthcare proposed by regulatory bodies and scientific societies and their potential effects on healthcare resources and CRC prognosis.Finally,we will show information regarding FIT-based surveillance as an alternative to endoscopic surveillance after high-risk polyp resection.To conclude,due to the coronavirus disease 2019 pandemic,FIT-based strategies have become extremely relevant since they enable a reduction of colonoscopy demand and access to the healthcare system by selecting individuals with the highest risk of CRC. | Noel Pin-Vieito Manuel Puga Daniel Fernández-de-Castro Joaquín Cubiella | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 4 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 5 | ASIC3,a sensor of acidic and primary inflammatory pain显示文摘 | Deval E Noel J Lay N | 2008 | EMBO J2008，27，22： | 1 |
| 6 | Influence of environmen- tal Vertical wind shear on the intensity of hurricanne-strength tropical cyclones in the Australian region显示文摘 | Linda A P Barry N H Noel E D | 2005 | Mon Wea Rev2005，133，： | 1 |
| 7 | No Genetic Diversity at Mo- lecular Markers and Strong Phenotypic Plasticity in Popula- tions of Ranunculus nodi? orus, an Endangered Plant Spe- cies in France 显示文摘 | Noel F Machon N Porcher E | 2007 | Annals of Botany2007，99，： | 1 |
| 8 | Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow显示文摘 | Tropel P Noel D Platet N Legrand P Benabid AL Berger F | 2004 | Exp Cell Res2004，295，2： | 1 |
| 9 | Isolation and char-acterization of mesenchymal stem cells from adult mouse bone marrow显示文摘 | Tropel P Noel D Platet N | 2004 | Exp Cell Res2004，295，33： | 1 |
| 10 | Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow显示文摘 | Tropel P Noel D Platet N | 2004 | Exp Cell Res2004，295，： | 1 |
| 11 | Carder phase tracking from turbo and LDPC coded signals affected by a frequency offset 显示文摘 | N Noels H Steendam M Moeneclaey | 2005 | IEEE Communications letters (S1089-7798)2005，9，91： | 1 |
| 12 | Enterprise logistics and supply chain structure: the role of fit显示文摘 | Gregory N Stock Noel P Greis John D Kasarda | 2000 | Journal of Operations Management2000，，5： | 1 |
| 13 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCYI, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance 显示文摘 | Papon N Noel T Florent M | 2007 | Antimicrob Agents Chemother2007，51，1： | 1 |
| 14 | Absorptive ca- pacity and NPD显示文摘 | Gregory N S Noel P G William A F | 2001 | Journal of High Technology Man-agement Research2001，，12： | 1 |
| 15 | Marketing and Technology: A Strategic co Alignment显示文摘 | Noel Capon and N Glazer | 1987 | Journal of Marketing1987，51，3： | 1 |
| 16 | 1 Population changes in Heterodera glycine sand its bacterial parasite Pasteuriasp, in naturally infested soil 显示文摘 | Atibalentja N Noel G R Liao T F et a | 1998 | Nematology1998，30，1： | 1 |
| 17 | A Theoretical Framework for Soft Information Based Synchronization in Iterative (Turbo) Receivers 显示文摘 | N Noels V Lottici A Dejonghe | 2005 | EURASIP Journal on Wireless Communications and Networking special issue on Advanced Signal Processing Algorithms for Wireless Communications ($1687-1472)2005，2005，2： | 1 |
| 18 | A new chemically defined medium for wine lactic acid bacteria显示文摘 | Terrade N Noel R Couillaud R | 2009 | Food Res Int2009，42，3： | 1 |
| 19 | Isolation and characterisation ofmesenchymal stem cells from adult mouse bone marrow显示文摘 | Tropel P Noel D Platet N | 2004 | Exp Cell Res2004，295，2： | 1 |
| 20 | The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla显示文摘 | JAILLON O AURY J M NOEL B POLICRITI A CLEPET C CASAGRANDE A CHOISNE N AUBOURG S VITULO N JU- BIN C VEZZI A LEGEAI F HUGUENEY P DASILVA C HORNER D MICA E JUBLOT D POULAIN J BRUYERE C BILLAULT A SEGURENS B GOUYVENOUX M UGARTE E CATTONARO F ANTHOUARD V VICO V DEL FABBRO C ALAUX M DI GASPERO G DUMAS V FELICE N PAILLARD S JUMAN I MOROLDO M SCALABRIN S CANAGUIER A LE CLAINCHE I MALACRIDA G DURAND E PESOLE G LAUCOU V CHATELET P MERDINOGLU D DELLEDONNE M PEZZOTYI M LECHARNY A SCARPELLI C ARTIGUE- NAVE F PE M E VALLE G MORGANTE M CABOCHE M ADAM-BLONDON A F WEISSENBACH J QUETIER F WINCKER P | 2007 | Nature2007，449，27： | 1 |
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