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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 3 | Validation of modifide multiple platform methods(MPM) of paradoxical sleep deprivation in rats显示文摘 | NUNES JR G TUFIK S | 1994 | Sleep Res1994，23，： | 1 |
| 4 | GSK-3/beta-catenin signaling axis in airway smooth muscle: role in mitogenic signaling显示文摘 | Nunes RO Sehmidt M Dueck G | 2008 | Am J Physiol Lung Cell Mol Physiol2008，，： | 1 |
| 5 | Aging effect on the reflectivity measurements of polychloroprene matrices containing carbon black and carbonyl-iron powder显示文摘 | Pinho M S Gregori M L Nunes R C R Soares B G | 2001 | Polymer Degradation and Stability2001，73，： | 1 |
| 6 | Excited-state proton transfer in gas-expanded liquids:the roles of pressure and composition in supercritical CO2/methanol mixtures显示文摘 | NUNES R M D ARNAUT L G SOLNTSEV K M | | 0，，34： | 1 |
| 7 | Validation of an immunoassay method for the determination of traces of carbaryl in vegetable and fruit extracts by liquid chromatography with photodiode array and mass spectrometric detection显示文摘 | Nunes G S Marco M P Ribeiro M L | 1998 | Journal of Chromatography A1998，823，1： | 1 |
| 8 | The NOD:Asignaling module that regulates apoptosis and host defense against pathogens显示文摘 | INOHARA N NUNE Z G | 2001 | Oncogene2001，20，： | 1 |
| 9 | Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death显示文摘 | Hockenbery D Nunes G Milliman C | 1990 | Nature1990，348，6299： | 1 |
| 10 | Bridged lamellae: crystal structure(s) of low molecular weight linear polyethylene 显示文摘 | Galland G B Mauler R S Nunes F F | 1999 | Macromolecules1999，32，： | 1 |
| 11 | RANi-mediated silencing of the myo- inositol phosphate synthase gene (GmMIPS) in trans-genic soybean inhibited seed development and reduced phytate content 显示文摘 | Nunes A C S Vianna G R Cuneo F Amaya F J Capdeville G Rech E L Arogao F J L | 2006 | P[anta2006，224，1： | 1 |
| 12 | Evaluation of a highly sensitive amperometric biosensor with low cholinesterase charge immobilized on a chemically modified carbon paste electrode for trace determination of carbamates in fruit, vegetable and water samples 显示文摘 | Nunes G S Grabaric B S Diaz-Cruz J M | 1999 | Analytica Chemica Acta1999，399，12： | 1 |
| 13 | Elect of neonatal hyperthyroidism on GH gene expression reprogramming and physiological repercussions in rat adulthood 显示文摘 | De Picoli Souzak Da Silva F G Nunes M T | 2006 | J Endocrinol2006，190，2： | 1 |
| 14 | Gating functions for multipath mitigation in GNSS BOC signals显示文摘 | Nunes F D Sousa F M G Leitao J M N | 2007 | IEEE Transactions on Aerospace and Electronic Systems2007，43，3： | 1 |
| 15 | A model for sustainable management of shellfish polyculture in coastal bays 显示文摘 | NUNES J P FERREIRA J G GAZEAU F | 2003 | Aquaculture2003，219，： | 1 |
| 16 | A model for sustainable management of shellfish polyculture in coastal bays 显示文摘 | Nunes J P Ferreira J G Gazeau F | 2003 | Aquaculture2003，219，14： | 1 |
| 17 | Gating functions for multipath mitigation in GNSS BOC signals显示文摘 | Nunes Fernando D Sousa Fernando M G Leitao Jose M N | 2007 | IEEE Transactions on Aerospace and Electronic Systems2007，43，3： | 1 |
| 18 | Varietal identification of coffee seeds by RAPD technique显示文摘 | Croehemore M L Nunes L M Andrade G A | 2004 | Brazilian Archives of Biology and Technology2004，47，1： | 1 |
| 19 | Excitedstate proton transfer in gas-expanded liquids:The roles of pressure and composition in supercritical CO2/methanol mixtures 显示文摘 | NUNES R M D ARNAUT L G SOLNTSEV K M | 2005 | J Am Chem Soc2005，127，11： | 1 |
| 20 | Validation of an immunoassay method for the determination of traces of carbaryl in vegetable and fruit extracts by liquid chromatography with photodiode array and mass spectrometric detection显示文摘 | NUNES G S MARCO M P RIBEIRO M L | 1998 | J Chromatogr A1998，823，12： | 1 |
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