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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | Susceptibility of multiresistant Gram-negative bacteria to Fosfomycin and performance of different susceptibility testing methods显示文摘 | Perdig(a)o-Neto LV Oliveira MS Rizek CF | 2014 | Antimicrob Agents Chemother2014，58，3： | 1 |
| 3 | Alanine aminotransferase and high sensitivity C-reactive protein:correlates of cardiovascular risk factors in youth显示文摘 | Oliveira AC Oliveira AM Almeida MS | 2008 | J Pediatr2008，152，3： | 1 |
| 4 | Alzheimer disease and the role of free radicals in the pathogenesis of the disease:therapeutic implications显示文摘 | Moreira PI Santos MS Oliveira CR | 2008 | CNS Neurol Disord Drug Targets2008，7，1： | 1 |
| 5 | Conventional radiationbiological dosimetry using frequencies of unstable chromosome aberration显示文摘 | Ramalho AT Costa ML and Oliveira MS | 1998 | Mutat Res1998，404，12： | 1 |
| 6 | Additive anticonvulsant effects of creatine supplementation and physical exercise against pentylenetetrazol-induced seizures显示文摘 | RAMBO LM RIBEIRO LR OLIVEIRA MS | | 0，，05： | 1 |
| 7 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
| 8 | Is hepatitis C virus a cause of idiopathic dilated cardiomyopathy? A systematic review of literature显示文摘 | Dos Reis FJ de Sousa TA Oliveira MS | 2006 | Braz J Infect Dis2006，10，3： | 1 |
| 9 | Effects of nemorosone,isolated from the plant Clusia rosea,on the cell cycle and gene expression in MCF-7 BUS breast cancer cell lines显示文摘 | Camargo MS Oliveira MT Santoni MM | 2015 | Phytomedicine2015，22，1： | 1 |
| 10 | Ampicillin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp显示文摘 | Oliveira MS Prado GV Costa SF | | 0，，6： | 1 |
| 11 | MicroRNA-100 acts as a tumor suppressor in human bladder carcinoma 5637 cells 显示文摘 | Oliveira JC Brassesco MS Morales AG | 2011 | Asian Pac J Cancer Prey2011，12，11： | 1 |
| 12 | Prediction of activity mode with global positioning system and accelerometer data显示文摘 | Troped PJ Oliveira MS Matthews CE | 2008 | Med Sci Sports Exerc2008，40，5： | 1 |
| 13 | Ischemic myocardial injuries after cardiac malformation repair in infants may be associ-ated with oxidative stress mechanisms 显示文摘 | Oliveira MS Floriano EM Matin SC | 2011 | Cardiovasc Pathol2011，20，1： | 1 |
| 14 | MicroRNA-100 acts as a tumor suppressor in human bladder carcinoma 5637 cells显示文摘 | Oliveira JC Brassesco MS Morales AG | 2011 | Asian Pacific J Cancer Prev2011，12，11： | 1 |
| 15 | Outbreak of herpang- ina in Brazilian Amazon in 2009 caused by Enterovirus B显示文摘 | Oliveira DB Campos RK Soares MS | 2014 | Arch Virol2014，159，5： | 1 |
| 16 | Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats显示文摘 | de Oliveira MS da Silva Fernandes MJ Scorza FA Persike DS Scorza CA da Ponte JB | 2010 | Brain Res Bull2010，83，5： | 1 |
| 17 | Anti-proliferative effect of the gastrin-release peptide receptor antagonist RC-3095 plus temozolomide in experimental glioblastonm models 显示文摘 | De Oliveira MS Cechim G Braganhol E | 2009 | J Neurooncol2009，93，2： | 1 |
| 18 | Detection of calicivir- uses associated with acute infantile gastroenteritis in Salvador, an urban center in Northeast Brazil显示文摘 | Xavier MP Oliveira SA Ferreira MS | 2009 | Braz J Med Biol Res2009，42，5： | 1 |
| 19 | Ampicillin/sulbactamcompared with polymyxins for the treatment of infectionscaused by carbapenem-resistant Acinetobacter spp显示文摘 | Oliveira MS Prado GV Costa SF | 2008 | J Anti-microb Chemother2008，61，6： | 1 |
| 20 | GM1 ganlioside induces vasodilation and increases catalase content in the brain 显示文摘 | Furian AF Oliveira MS Royes LF | 2007 | Free Radie Biol Med2007，43，6： | 1 |
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