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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 3 | Resistance to antimicrobial agents in lactobacilli isolated from caper fermentations显示文摘 | PULIDO R P OMAR N B LUCAS R | 2005 | Antonie van Leeuwenhoek2005，88，34： | 1 |
| 4 | Evidence for a role of safieylie acid in the oxidative damage generated by NaCI and osmotic s tess in A rabi dopsis seedlings显示文摘 | Omar B Victoriano V Miguel A B | 2001 | Plant Physiol2001，126，： | 1 |
| 5 | Convenient, room-temperature, amine-assisted routes to metal sulfides, sele-nides and tellurides显示文摘 | Dusastre V’Omar B Parkin I P | 1997 | J Chem SocfDalton Trans1997，，19： | 1 |
| 6 | Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes re- sistance in glucagon receptor deficient mice显示文摘 | Omar BA Andersen B Hald J | 2014 | Diabetes2014，63，1： | 1 |
| 7 | Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes 显示文摘 | Berggreen C Gormand A Omar B | 2009 | Am J Physiol Endocrinol Metab2009，296，4： | 1 |
| 8 | Systematic re- view of oncological outcomes following surgical man agement of localised renal cancer显示文摘 | MacLennan S Imanmra M Lapitan M C Omar M I Lain T B Hilvano-Cabungcal A M | 2012 | Eur Urol2012，61，97： | 1 |
| 9 | Polyphasic study of the spatial distribution of microorganisms in Mexican pozol, a fermented maize dough demonsWates the need for cultivation-independent methods to investigate traditional fermentations 显示文摘 | AMPE F OMAR B N MO IZAN C | 1999 | Applied Environmental Microbiology1999，65，： | 1 |
| 10 | Effects of metsulfur on methyl on amylase, urease and protease activities in two soils显示文摘 | lsmail B S Yapp K F Omar O | 2000 | Aust J SoilRes2000，，36： | 1 |
| 11 | Explicit nonlinear fi- nite element geometric analysis of parabolic leaf spring under various loads 显示文摘 | Kong Y S Omar M Z Chua L B | 2013 | The Scientific World Journal2013，，： | 1 |
| 12 | An adaptive local binarization method for document images based on a novel thresholding method and dynamic windows显示文摘 | Bataineh B Abdullah S N H S Omar K | 2011 | Pattern Recognition Letters2011，32，14： | 1 |
| 13 | Analysis of Amoxyeillin in Cpsules and Oral Suspensionsby High-performance Liquid Chromatography显示文摘 | Omar Shakoor Robert B Taylor Ronal R Moody | 1995 | Analyst1995，120，8： | 1 |
| 14 | Polyphasie Study of the Spatial Distribution of Microorganisms in Mexican Pozol, a Fermented Maize Dough, Demonstrates the Need for Cultivation-Independent Methods To Investigate Traditional Fermentations显示文摘 | Ampe F Omar N B Moizan C | 1999 | Appl Environ Microbiol1999，65，12： | 1 |
| 15 | Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts 显示文摘 | WANG B OMAR A ANGELOVSKA T | 2007 | Am J Physiol Heart Circ Physiol2007，293，： | 1 |
| 16 | Microbial Community Dynamics during Production of the Mexican Fermented Maize Dough Pozol 显示文摘 | Omar N B Ampe F | 2000 | Appl Environ Microbiol2000，66，9： | 1 |
| 17 | Web services architecture for user control and management of optical internet networks显示文摘 | Bill S Andrew B Omar C | 2004 | IEEE2004，92，9： | 1 |
| 18 | Injection moulded microcellular wood fibrepolypropylene composites 显示文摘 | Andrzej K B Omar F | 2006 | Compositesm ( Part A ) : Applied Science and Manufacturing2006，37，9： | 1 |
| 19 | Removal of Dyes and Industrial Dye Wastes by Magnesium Chloride 显示文摘 | Tan B H Teng T T Omar A K M | 2000 | Water Research2000，34，2： | 1 |
| 20 | Changes in fatty acid profile during larval development of freshwater prawn Macrobrachium rosenbergii (De Man) 显示文摘 | ROUSTAIAN P KAMARUDIN M S OMAR H B | 1999 | AquacRes1999，30，： | 1 |
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