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| 1 | 中国社区卫生服务该怎样满足患者需求:一项全国性的代表性调查显示文摘目的中国自2009年起开展社区卫生服务,截至2014年已建成社区卫生服务中心8 669家,拥有社区卫生服务工作者30万人。然而,至社区卫生服务中心就诊的患者数并不多,因为人们对全科医生缺乏信任,但对专科医生过度依赖。方法于2015年9—12月,采用分层随机抽样法,按社区卫生服务中心在城市和郊区的分布比例(2∶1)在中国东、中、西部地区抽取样本社区卫生服务中心,并采用不同问卷对在其工作的资深临床医生和全科医生进行调查。两套问卷内容均涉及所在社区卫生服务中心的服务人口特征、开办的临床和健康教育活动情况。158例资深临床医生和3 580例全科医生对调查进行了有效应答,问卷有效应答率分别为84%和86%。结果社区卫生服务中心的中位医生数为8例、中位护士数为13例,但仅半数医生注册为全科医生,极少数护士接受过专业的全科培训。98%的社区卫生服务中心配有听诊器,97%配有血压计,但仅43%配有检眼镜,64%配有妇科检查仪器。社区卫生服务中心倾向于有选择地向部分慢性病患者提供医疗服务。全科医生每天接诊的中位患者数为12.5例。多因素分析结果显示,在举办主体为私立医院的社区卫生服务中心、配有药剂师和护士的社区卫生服务中心,全科医生的每日接诊患者数较多。结论中国拥有规模较大的、以年轻人为主的全科医疗服务团队,并配有持续性专业培训;社区卫生服务中心配有基础医疗设备,但仅少数可为患者提供多种常见病的综合性医疗服务;社区卫生服务中心就诊患者数仍较少。 | WONG W C W JIANG S ONG J J 本刊编辑部 | 2017 | 中国全科医学2017，20，19： | 6 |
| 2 | Biomarkers in Barrett's esophagus and esophageal adenocarcinoma:Predictors of progression and prognosis显示文摘Barrett’s esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett’s esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett’s esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett’s esophagus and EA and to discuss what is required to move the field forward towards clinical application. | Chin-Ann J Ong Pierre Lao-Sirieix Rebecca C Fitzgerald | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 3 | Anemia and iron deficiency in gastrointestinal and liver conditions显示文摘Iron deficiency anemia(IDA) is associated with a number of pathological gastrointestinal conditions other than inflammatory bowel disease, and also with liver disorders. Different factors such as chronic bleeding, malabsorption and inflammation may contribute to IDA. Although patients with symptoms of anemia are frequently referred to gastroenterologists, the approach to diagnosis and selection of treatment as well as follow-up measures is not standardized and suboptimal. Iron deficiency, even without anemia, can substantially impact physical and cognitive function and reduce quality of life. Therefore, regular iron status assessment and awareness of the clinical consequences of impaired iron status are critical. While the range of options for treatment of IDA is increasing due to the availability of effective and well-tolerated parenteral iron preparations, a comprehensive overview of IDA and its therapy in patients with gastrointestinal conditions is currently lacking. Furthermore, definitions and assessment of iron status lack harmonization and there is a paucity of expert guidelines on this topic. This review summarizes current thinking concerning IDA as a common co-morbidity in specific gastrointestinal and liver disorders, and thus encourages a more unified treatment approach to anemia and iron deficiency, while offering gastroenterologists guidance on treatment options for IDA in everyday clinical practice. | Jürgen Stein Susan Connor Garth Virgin David Eng Hui Ong Lisandro Pereyra | 2016 | World Journal of Gastroenterology2016，22，35： | 5 |
| 4 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 5 | Nicotine and inflammatory neurological disorders显示文摘香烟烟是显著地包括肺癌症和呼吸感染增加疾病的发生的一个主要健康风险因素。然而,正在增加吸烟者们有煽动性的一些和 neurodegenerative 疾病的更低的发生的证据。烟碱是香烟烟的主要抑制免疫力的成分,它两个都禁止天生、适应的有免疫力的回答。不同于香烟烟,烟碱还没被认为是致癌物并且事实上,可以作为 neuroprotective 和反煽动性的代理人有治疗学的潜力。这评论提供在免疫系统上总结烟碱的效果的一个提要并且它的(烟碱) 在各种各样的神经病学的疾病上影响。 | Wen-Hua PIAO Denise CAMPAGNOLO Carlos DAYAO Ronald J LUKAS Jie WU Fu-D ong SHI | 2009 | Acta Pharmacologica Sinica2009，30，6： | 3 |
| 6 | Intestinal stem cells and the colorectal cancer microenvironment显示文摘Colorectal cancer(CRC)remains a highly fatal condition in part due to its resilience to treatment and its propensity to spread beyond the site of primary occurrence.One possible avenue for cancer to escape eradication is via stem-like cancer cells that,through phenotypic heterogeneity,are more resilient than other tumor constituents and are key contributors to cancer growth and metastasis.These proliferative tumor cells are theorized to possess many properties akin to normal intestinal stem cells.Not only do these CRC'stem'cells demonstrate similar restorative ability,they also share many cell pathways and surface markers in common,as well as respond to the same key niche stimuli.With the improvement of techniques for epithelial stem cell identification,our understanding of CRC behavior is also evolving.Emerging evidence about cellular plasticity and epithelial mesenchymal transition are shedding light onto metastatic CRC processes and are also challenging fundamental concepts about unidirectional epithelial proliferation.This review aims to reappraise evidence supporting the existence and behavior of CRC stem cells,their relationship to normal stem cells,and their possible dependence on the stem cell niche. | Bryan A Ong Kenneth J Vega Courtney W Houchen | 2014 | World Journal of Gastroenterology2014，20，8： | 2 |
| 7 | Moving element method for train-track dynamics显示文摘 | Koh C G Ong J S Y Chua D K H Feng J | 2003 | International Journal for Numerical Methods in Engineering2003，56，： | 1 |
| 8 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Water Research2003，37，： | 1 |
| 9 | Above and below groundinteraction in agroforestry system s显示文摘 | Ong C K Corlett J E Singh R P | 1991 | Forest Ecology andManagement1991，45，1： | 1 |
| 10 | Deposition of highly adhesive ZrO2 coating on Ti and CoCrMo implant materials using plasma spraying显示文摘 | Yang Y Ong J Tian J | 2003 | Biomaterials2003，24，： | 1 |
| 11 | Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia Miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells 显示文摘 | Liu J Shen H M Ong C N | 2001 | Life Sciences2001，69，16： | 1 |
| 12 | Vertebral artery domi- nance contributes to basilar artery culwatult and peri-verte brobasilar junctional infarcts显示文摘 | H ong J M Chung CS Bang OY | 2009 | J Neurol Neurosurg Psychia- try2009，80，： | 1 |
| 13 | An efficient method forcomputing leave-one-out error in support vector machines withgaussian kernels 显示文摘 | Lee M M S Keerthi S S Ong C J ei al | 2004 | IEEE Transition on Neural Networks2004，15，3： | 1 |
| 14 | The development of microalbuminuria is associated with raised longitudinal adiponectin levels in female but not male adolescent patients with type 1 diabetes显示文摘 | Amin R Frystyk J Ong K | | 0，，： | 1 |
| 15 | Thirty-day incidence and sixmonth clinical outcome of thrombotic stent occlusion after baremetal, sirolimus, or paclitaxel stent implantation 显示文摘 | Ong A T Hoye A Aoki J | 2005 | J Am Coll Cardiol2005，45，6： | 1 |
| 16 | Geographic-time distribution of ambulance calls in Singapore:utility of geographic information system in ambulance deployment (CARE 3)显示文摘 | ONG M E NG F S OVERTON J | 2009 | Ann Acad Med Singapore2009，38，3： | 1 |
| 17 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors 显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Water Res2003，37，3： | 1 |
| 18 | Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, siroli- mus, or paclitaxel stent implantation显示文摘 | Ong AT Hoye A Aoki J | 2005 | J Am Coil Cardiol2005，45，6： | 1 |
| 19 | Orientation characterization and photoconductive properties of ethylenediamine bridged silicon phthalocyanine polymer thin film显示文摘 | SIM J H ONG B S REED C A | 1996 | Thin Solid Films1996，40，2： | 1 |
| 20 | Texture determinants in cooked, parboiled rice Ⅰ: Rice starch amylose and the fine structure of amylopectin 显示文摘 | Ong M H Blanshard J M V | 1995 | J Cereal Sci1995，21，： | 1 |
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