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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Production of Normal Mice From Spermatozoa Denatured with High Alkali Treatment before ICSI显示文摘 | Li C Mizutani E Ono T | 2009 | Reproduction2009，137，5： | 1 |
| 3 | J Power Sources显示文摘 | Matsuoka O Hiwara A Omi T Toriida M Hayashi T Tanaka C Saito Y Ishida T Tan H Ono S S Yamamoto S | 2002 | 108:1282002，108，： | 1 |
| 4 | Expression of estrogen receptor 13 in rat bones显示文摘 | Onoe Y Miyaura C Ohta H | 1997 | Endocrinology1997，138，： | 1 |
| 5 | 查看详情显示文摘 | Ryo Ono Tobaru C Teramoto Y Oda T | | 0，，： | 1 |
| 6 | Lignan derivatives and a norditerpene from the seeds of Vitex negundo显示文摘 | Ono M Nishida Y Masuoka C | 2004 | J Nat Prod2004，67，12： | 1 |
| 7 | Expression of estrogen receptor beta in rat bone显示文摘 | Onoe Y Miyaura C Ohta H | 1997 | Endocrinology1997，138，10： | 1 |
| 8 | Inhibition of class Ⅱb histone deacetylase significantly improves cloning efficiency in mice显示文摘 | Ono T Li C Mizutani E Terashita Y Yamagata K and Wakayama T | | 0，，06： | 1 |
| 9 | Real time diagnostics of gas/water assisted injection moulding using integrated ultrasonic sensors显示文摘 | Mulvaney-Johnson L Cheng C C Ono Y | 2007 | Plastics Rubber and Composites2007，36，3： | 1 |
| 10 | Extensive MHC variability in cichlid fishes on Lake Malwi显示文摘 | Klein D Ono H O'huigin C | | 0，，： | 1 |
| 11 | Real-time diagnosis of coinjection molding using ultrasound显示文摘 | Cheng C C Ono Y Jen C K | 2007 | Polymer Engineering and Science2007，47，9： | 1 |
| 12 | Ictal SPECT and paired stimulation SEP recovery curve in a patient with paroxysmal kinesigenic choreoathetosis显示文摘 | Yamashiro D Aihara M Ono C | 2002 | No To Hattasu2002，34，： | 1 |
| 13 | Exon-intron organization of fish major histocompatibility complex class Ⅱ B genes显示文摘 | Ono H O'hUigin C Vincek V | 1993 | Immunogenetics1993，38，3： | 1 |
| 14 | Propagation of senescent mice using nuclear transfer embryonic stem cell lines 显示文摘 | Mizutani E Ono T Li C | 2008 | Genesis2008，46，9： | 1 |
| 15 | Modified POSSUM to predict postoperative morbidity following gastrectomy 显示文摘 | Otsuka Y Kunisaki C Ono H | 2007 | Hepatogastroenterology2007，54，76： | 1 |
| 16 | Intracytoplasmic sperm in- jection with mouse spermatozoa preserved without freezing for six months can lead to full-term development 显示文摘 | Li C Mizutani E Ono T | 2011 | Biol Reprod2011，85，6： | 1 |
| 17 | NMR structure of the histidine kinase domain of the E coli osmosensor EnvZ显示文摘 | Tanaka T Saha S K Tomomori C Ishima R, Liu D, Tong K I, Park H, Dutta R, Qin L, Swindells M B, Yamazaki T, Ono A M, Kainosho M, Inouye M, Ikura M | | 0，，： | 1 |
| 18 | Mulberry latex rich in antidiabetic sugarmimic alkaloids forces dieting on caterpillars显示文摘 | Konno K Ono H Nakamura M Tateishi K Hirayama C Tamura Y Hattori M Koyama A Kohno K | | 0，，： | 1 |
| 19 | Antiproliferative and apoptosis-inducing activity of nobiletin against three subtypes of human breast cancer cell lines 显示文摘 | CHEN C ONO M TAKESHIMA M | 2014 | Anticancer Res2014，34，4： | 1 |
| 20 | C-prolinylquercelins from the Yellow Cocoon Shell of the Silkworm, Bombyx mori显示文摘 | HIRAYAMA C ONO H TAMURA Y | 2006 | Phytochemistry2006，，67： | 1 |
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