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| 1 | From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases显示文摘Two of the most common neurodegenerative disorders-Alzheimer’s and Parkinson’s diseases-are characterized by synaptic dysfunction and degeneration that culminate in neuronal loss due to abnormal protein accumulation.The intracellular aggregation of hyper-phosphorylated tau and the extracellular aggregation of amyloid beta plaques form the basis of Alzheimer’s disease pathology.The major hallmark of Parkinson’s disease is the loss of dopaminergic neurons in the substantia nigra pars compacta,following the formation of Lewy bodies,which consists primarily of alpha-synuclein aggregates.However,the discrete mechanisms that contribute to neurodegeneration in these disorders are still poorly understood.Both neuronal loss and impaired adult neurogenesis have been reported in animal models of these disorders.Yet these findings remain subject to frequent debate due to a lack of conclusive evidence in post mortem brain tissue from human patients.While some publications provide significant findings related to axonal regeneration in Alzheimer’s and Parkinson’s diseases,they also highlight the limitations and obstacles to the development of neuroregenerative therapies.In this review,we summarize in vitro and in vivo findings related to neurogenesis,neuroregeneration and neurodegeneration in the context of Alzheimer’s and Parkinson’s diseases. | Debia Wakhloo Jane Oberhauser Angela Madira Sameehan Mahajani | 2022 | Neural Regeneration Research2022，17，12： | 2 |
| 2 | Varieties of calcium-acti-vated potassium channels显示文摘 | Oberhauser A Labarca P | 1989 | Annu Rev Physiol1989，51，： | 1 |
| 3 | Synergistic effect between few layer graphene and carbon nanotube supports for palladium catalyzing electrochemical oxidation of alcohols显示文摘Few layer graphene (FLG), multi-walled carbon nanotubes (CNTs) and a nanotube-graphene composite (CNT-FLG) were used as supports for palladium nanoparticles. The catalysts, which were characterized by transmission electron microscopy, Raman spectroscopy and X-ray diffraction, were used as anodes in the electrooxidation of ethanol, ethylene glycol and glycerol in half cells and in passive direct ethanol fuel cells. Upon Pd deposition, a stronger interaction was found to occur between the metal and the nanotube-graphene composite and the particle size was significantly smaller in this material (6.3 nm), comparing with nanotubes and graphene alone (8 and 8.4 nm, respectively). Cyclic voltammetry experiments conducted with Pd/CNT, Pd/FLG and Pd/CNT-FLG in 10 wt% ethanol and 2 M KOH solution, showed high specific currents of 1.48, 2.29 and 2.51 mA μg-1 Pd , respectively. Moreover, the results obtained for ethylene glycol and glycerol oxidation highlighted the excellent electrocatalytic activity of Pd/CNT-FLG in terms of peak current density (up to 3.70 mA μg-1 Pd for ethylene glycol and 1.84 mA μg-1 Pd for glycerol, respectively). Accordingly, Pd/CNT-FLG can be considered as the best performing one among the electrocatalysts ever reported for ethylene glycol oxidation, especially considering the low metal loading used in this work. Direct ethanol fuel cells at room temperature were studied by obtaining power density curves and undertaking galvanostatic experiments. The power density outputs using Pd/CNT, Pd/FLG and Pd/CNT-FLG were 12.1, 16.3 and 18.4 mW cm2 , respectively. A remarkable activity for ethanol electrooxidation was shown by Pd/CNT-FLG anode catalyst. In a constant current experiment, the direct ethanol fuel cell containing Pd/CNT-FLG could continuously deliver 20 mA cm2 for 9.5 h during the conversion of ethanol into acetate of 30%, and the energy released from the cell was about 574 J. | Bruno F. Machado Andrea Marchionni Revathi R. Bacsa Marco Bellini Julien Beausoleil Werner Oberhauser Francesco Vizza Philippe Serp | 2013 | Journal of Energy Chemistry2013，22，2： | 1 |
| 4 | Effects of angiotensin-(1~7)and other bioactive components of the rennin-angiotensin system on vascular resistance and noradrenaline release in rat kidney 显示文摘 | Stegbauer J Vonend O Oberhauser V | 2003 | Journal of Hypertension2003，21，7： | 1 |
| 5 | Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes 显示文摘 | Bilkovski R Schulte DM Oberhauser F | 2010 | J Biol Chem2010，285，9： | 1 |
| 6 | Transcrip- tion factor FBI - 1 acts as a dual regulator in adipogenesis by coor- dinated regulation of cyclin - A and E2F - 4 显示文摘 | LAUDES M BILKOVSKI R OBERHAUSER F | 2008 | J Mol Med (Berl)2008，86，5： | 1 |
| 7 | Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein(a)levels in human subjects with rheumatoid diseases显示文摘 | Schultz O Oberhauser F Saech J | 2010 | PLo S One2010，5，14： | 1 |
| 8 | Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein(a) levels in human subjects with rheumatoid diseases显示文摘 | Schultz O Oberhauser F Saech J | 2010 | PLoS One2010，5，14： | 1 |
| 9 | Thin Solid Films显示文摘 | Oberhauser P Abermann R | 1999 | 350:59-661999，350，： | 1 |
| 10 | Pulling on hair (pins)显示文摘 | Fernandez J M Chu S Oberhauser A F | 2001 | Science2001，292，5517： | 1 |
| 11 | Thin Solid Films显示文摘 | Oberhauser P Abermann R | 2003 | 434:24-292003，434，： | 1 |
| 12 | Investigating the dimen- sion functioning from a condition-specific perspective and the qualifier scale of the International Classification of Functioning, Disability and Health based on Rasch analyses 显示文摘 | Bostan C Oberhauser C Cieza A | 2012 | Am J Phys Med Rehabil2012，，： | 1 |
| 13 | Soft glassy dynamics in polypropylene-clay nanocomposites 显示文摘 | TREECE M A OBERHAUSER J P | 2007 | Macromolecules2007，40，： | 1 |
| 14 | RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome显示文摘 | Isken A Golczak M Oberhauser V | 2008 | Cell Metab2008，7，3： | 1 |
| 15 | Angotensin-(1-7) modulates vascular resistance and sympathetic neurotransmission in kidneys of spontaneously hypertensive rats 显示文摘 | Steghauer J Oberhauser V Vonend O | 2004 | Cardiovoscular Res2004，61，： | 1 |
| 16 | AT1 and AT2 receptor antagonists inhibit Ang Ⅱ mediated facilitation of noradrenal inereleasein humanatria显示文摘 | Eimuayed M Stegbauer J Oberhauser V | 2004 | J Cardiovasc Pharmaeol2004，43，2： | 1 |
| 17 | Secondary forest regeneration beneath pine (Pinus kesiya) plantations in the northern Thai highlands: a chronosequence study 显示文摘 | Oberhauser U | 1997 | Forest Ecology and Management1997，99，： | 1 |
| 18 | The molecular elasticity of tenascin,an extracellular matrix protein显示文摘 | Oberhauser A F Marszalek P E Erickson H P | 1998 | Nature1998，393，： | 1 |
| 19 | Reverse engineering of the giant muscle protein titin显示文摘 | Linke W A Oberhauser A F | 2002 | Nature2002，418，： | 1 |
| 20 | Varieties of Calcium -activated potassium channels 显示文摘 | Latorre R Oberhauser A Labarca D and Alvarez O | 1989 | Annu Rev Physiol1989，51，： | 1 |
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