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| 1 | Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration:In vivo structural and functional assessment显示文摘Peripheral nerve injuries account for roughly 3%of all trauma patients with over 900,000 repair procedures annually in the US.Of all extremity peripheral nerve injuries,51%require nerve repair with a transected gap.The current gold-standard treatment for peripheral nerve injuries,autograft repair,has several shortcomings.Engineered constructs are currently only suitable for short gaps or small diameter nerves.Here,we investigate novel nerve guidance conduits with aligned microchannel porosity that deliver sustained-release of neurogenic 4-aminopyridine(4-AP)for peripheral nerve regeneration in a critical-size(15 mm)rat sciatic nerve transection model.The results of functional walking track analysis,morphometric evaluations of myelin development,and histological assessments of various markers confirmed the equivalency of our drug-conduit with autograft controls.Repaired nerves showed formation of thick myelin,presence of S100 and neurofilament markers,and promising functional recovery.The conduit’s aligned microchannel architecture may play a vital role in physically guiding axons for distal target reinnervation,while the sustained release of 4-AP may increase nerve conduction,and in turn synaptic neurotransmitter release and upregulation of critical Schwann cell neurotrophic factors.Overall,our nerve construct design facilitates efficient and efficacious peripheral nerve regeneration via a drug delivery system that is feasible for clinical applications. | Ohan S.Manoukian Swetha Rudraiah Michael R.Arul Jenna M.Bartley Jiana T.Baker Xiaojun Yu Sangamesh G.Kumbar | 2021 | Bioactive Materials2021，6，9： | 2 |
| 2 | Traurnatic subarachnoid hemorrhage: our current understanding and its evolution over the past half century显示文摘 | Arrnin SS Col ohan AR Zhang JH | 2006 | Neurol Res2006，28，4： | 1 |
| 3 | Aberrant serum adiponectin levels in women with uterine leiomyomas显示文摘 | Chen H$ Ohan TF Chung YF et aI | 2004 | Gynecol Obstet Invest2004，56，3： | 1 |
| 4 | Expression of interleukin-10 in advanced human atherosclerotic plaques:relation to in clucible nitric oxide synthase expression and cell death显示文摘 | Mallat I Heymes C Ohan J | 1999 | Arterioscler Thromb Vasc Biol1999，19，3： | 1 |
| 5 | Colocalization of CPP32 with apoptotic cells in human atherosclemtic plaques显示文摘 | Mallat Z Ohan J Leseche G | 1997 | Circulation1997，96，2： | 1 |
| 6 | Review on material properties of AZO thin films useful as epi-n-TCOs in opto-electronic (SIS soar cells, polymeric LEDs)devices显示文摘 | RANMAMOORTHY K KUMAR K CHANDRAM- OHAN R | 2006 | Mater Sei Eng B2006，126，1： | 1 |
| 7 | Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity 显示文摘 | Mallat Z Huge1 B Ohan J | 1999 | Circulation1999，99，3： | 1 |
| 8 | Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects显示文摘 | Ohanning GL Tamura T Johnston KE | 2000 | J Med Genet2000，37，12： | 1 |
| 9 | Expression of interleukin- 10 in advanced human atherosclerotic plaques: Relation to inducible nitric oxide synthas expression and cell death 显示文摘 | Mallat Z Heymes C Ohan J | 1999 | Arterioseler Thromb Vasc Biol1999，19，3： | 1 |
| 10 | High-reso- lution photonic bandgap fiber-based biochemical sensor 显示文摘 | Sun Jian Ohan Ohi-Ohiu Dong Xin-Yong | 2007 | : Journal of Biomedical Optics2007，12，04： | 1 |
| 11 | Expression of interleukin-10 in advanced human atherosclerotic plaques:relation to inducible nitric oxide synthase expression and cell death显示文摘 | Heymes C Ohan J | 1999 | Arterioscler Thromb Vasc Biol1999，19，： | 1 |
| 12 | Expression of interleukin-10 in advanced human atherosclerotic plaques :relation to inducible nitric oxide synthase expression and cell death 显示文摘 | Mallat Z Heymes C Ohan J | 1999 | Arterioscler Thromb Vasc Biol1999，19，3： | 1 |
| 13 | Above-knee femoropopliteal bypass grafting using endothelial cell seeded PTFE grafts: five-year clinical experience显示文摘 | Leseche G Ohan J Bouttier S | 1995 | Ann Vasc Surg1995，，： | 1 |
| 14 | Evaluation of suspected pulmonary embolism utili- zing end-tidal CO2 and D-dimer显示文摘 | ]OHANNING J M VEVERKA T J BAYS R A | 1999 | Am J Surg1999，178，2： | 1 |
| 15 | Expression of interleukin-10in advanced human afllerosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death 显示文摘 | Mallat Z Heymes C Ohan J | 1999 | Arterioscler Thromb Vasc Biol1999，19，3： | 1 |
| 16 | Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen 显示文摘 | Ohan M P Weadock K S Duma M G | 2002 | Journal of Biomedecial Material Research2002，60，： | 1 |
| 17 | Clinical characteristics of an outbreak of hand, foot and mouth disease in Singapore显示文摘 | Shah VA Chong CY Ohan KP | 2005 | Ann Acad Ned Singapore2005，52，5： | 1 |
| 18 | Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques:a role for apoptsis in plaque thrombogenicity显示文摘 | Mallat Z Hugel B Ohan J | 1999 | Circulation1999，99，： | 1 |
| 19 | Damperwinding influence onunbalanced magnetic pull in salient pole gen-erators with rotor eccentricity 显示文摘 | MATTIAS WALLIN OHAN BLADH URBAN LUNDIN | 2013 | IEEE Transactions on Magnet-ics2013，49，9： | 1 |
| 20 | Expression of interleukin IL-10 in advanced human atherosclerotic plaques:relation to inducible nitric oxide synthase expression and cell death显示文摘 | MALLAT Z HEYMES C OHAN J | 1999 | Atheroscler Thromb Vasc Biol1999，19，3： | 1 |
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