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| 1 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 2 | 世界家庭医生组织(WONCA)研究论文摘要汇编——帕金森病患者对诊断流程不满意度影响因素的横断面调查研究显示文摘背景帕金森病(PD)的诊断流程通常比较复杂。诊断流程可以影响到患者的自信、就医满意度以及对医务人员的信任情况。尽管诊断结果对患者造成的影响与医务人员无关,但是医务人员可以影响患者在诊断流程中的感受。本研究旨在调查PD患者对诊断流程的不满意度并探究相关影响因素。方法本项横断面研究在902例来自于荷兰帕金森病协会的PD患者中开展。每例患者均被要求书写其诊断流程。采用自行设计的赋值表对数据进行整理。各整理者之间的误差情况采用Cohen's kappa系数进行评价。使用χ~2检验和多因素Logistic回归分析评估患者对诊断流程的不满意度与性别、文化程度、诊断流程时长、患者与全科医生及神经科医生的沟通情况、参与诊断医务人员人数、是否存在二次诊断(包括提出进行二次诊断者)以及延迟诊断(患者认为有人导致了其延迟诊断也考虑在内)之间的关系。采用亚组分析探究不同性别患者对诊断流程不满意度之间的差异。结果 16.4%的PD患者明确表示对诊断流程不满意,4.8%的患者表示对诊断流程很满意。各整理者之间的误差情况Cohen's kappa系数为0.82。患者文化程度较低、参与诊断医务人员超过必要人数1人以上、患者提出进行二次诊断以及由医务人员原因导致的延迟诊断是PD患者对诊断流程不满意的危险因素。当只有全科医生与神经科医生参与诊断时,女性患者对诊断流程的不满意程度超过男性患者。结论 PD患者对诊断流程的不满意度与较低文化程度、患者提出进行二次诊断以及延迟诊断相关。了解这些因素后,如全科医生特别注意与患者进行沟通并且与患者一起进行临床决策,可以减少患者在诊断流程中的不良感受。此举有利于增加患者对医生的信任度,而患者对医生的信任度在以后的治疗过程中极其重要。 | PLOUVIER A O A OLDE HARTMAN T C DE BONT O A 本刊编辑部 | 2017 | 中国全科医学2017，20，29： | 2 |
| 3 | The cancer/testis genes:review,standardization,and commentary显示文摘 | Simpson A J Old L J | 2004 | Cancer Immunity2004，4，： | 1 |
| 4 | Selective etching of semicrystalline polymers:CF4 gas plasma treatment of poly (ethylene)显示文摘 | Olde Riekerink M B Terlingen J G A Engbers G H M | 1999 | Langmuir1999，15，14： | 1 |
| 5 | Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6显示文摘 | Nelson TE Olde Engberink A Hernandez R | 2012 | Brain behavior and immunity2012，26，6： | 1 |
| 6 | Selective etching of semicrystalline polymers: CF4 gas plasma treatment of poly(ethylene) 显示文摘 | Olde Riekerink M B Terlingen J G A Engbers G H M | 1999 | Langmuir1999，15，14： | 1 |
| 7 | An endotoxin induced serum factor that cause necrosis of tmors显示文摘 | Carswell E A Old L J Kassel R L | 1975 | Pris Natal Acad Aci USA1975，72，： | 1 |
| 8 | Design and deployment of a satellite constellation using collaborative optimization显示文摘 | Budianto I A Olds J R | | 0，，06： | 1 |
| 9 | Tumor rejection antigens of chemically induced sarcomas of in bred mice显示文摘 | Srivastava P K Deleo A B Old L J | 1986 | Proc Natl Acad Sci1986，83，34： | 1 |
| 10 | Design and deployment of satellite constellation using collaborative optimization显示文摘 | Budianto I A Olds J R | 2004 | Journal of Spacecraft and Rockets2004，41，6： | 1 |
| 11 | Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states显示文摘 | Old E A Malcangio M | 2012 | Curr Opin Pharmacol2012，12，： | 1 |
| 12 | The cancer/testis genes:review,standardization,and commentary显示文摘 | SCANLAN M J SIMPSON A J OLD L J | 2004 | Cancer Im-mun2004，4，： | 1 |
| 13 | Conciderations for phased array ultrasonics in a fully futomated inspertion systen显示文摘 | Kramb V A Olding R B Sebastian J R | | 0，，23： | 1 |
| 14 | T-cell-mediated cytotoxicity against autologous malignant melanoma: analysiswith interleukin 2-dependent T-cell cultures 显示文摘 | Knuth A Danowski B Oettgen HF Old LJ | 1984 | Proc Natl Acad Sci USA1984，81，： | 1 |
| 15 | High-permittivity temperature-stable ceramic dielectrics withlow microwave loss 显示文摘 | KELL R C GREENHAM A C OLDS G C E | 1973 | J Am Ceram Soc1973，56，7： | 1 |
| 16 | High-permittivicy temperature-stable ceramic dielectrics with low microwave toss 显示文摘 | KELL R C GREEN A C OLDS G | 1973 | J Am Ceram Soc1973，56，7： | 1 |
| 17 | Simultaneous humoral and cellular immune response against cancer-testis antigen NYESO-hdefinition of human histocompatibility leukocyte antigen (HLA) -A2-binding peptide epitopes 显示文摘 | J ger E Chen YT Drijfhout JW Karbach J Ringhoffer M Jager D Arand M Wada H Noguchi Y Stockert E Old LJ Knuth A | 1998 | J Exp Med1998，187，： | 1 |
| 18 | The cancer/testis genes:review,standardization,and commentary显示文摘 | SCANLAN M J SIMPSON A J OLD L J | 2004 | Cancer Immun2004，23，： | 1 |
| 19 | An endotoxin-induced serum factor that causes necrosis of tumors显示文摘 | Carswell E A Old L J Kassel R L | | 0，，： | 1 |
| 20 | Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice显示文摘 | Sela U Olds P Park A | 2011 | J Exp Med2011，208，12： | 1 |
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