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| 1 | 高级别(WHO G3)胰腺神经内分泌肿瘤分类中形态学和生物学的异质性:包括分化好和分化差的肿瘤显示文摘WHO(2010)分类推荐胰腺神经内分泌肿瘤(PanNETs)的分级建立在核分裂象和Ki-67增殖指数的基础上,2级(G2)PanNETs定义为核分裂象2~20个/10HPF或Ki-67增殖指数在3%~20%之间,3级(G3)胰腺神经内分泌癌(NEC)定义为核分裂象〉20个/10HPF或Ki-67增殖指数〉20%。 | Basturk O Yang Z Tang L H 魏建国 许春伟 邰艳红 | 2015 | 临床与实验病理学杂志2015，31，4： | 25 |
| 2 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 3 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 4 | Antibacterial activity of Lawsonia inermis Linn(Henna) against Pseudomonas aeruginosa显示文摘Objective:To investigate the antibacterial activity of henna(Lawsonia inermis Linn) obtained from different regions of Oman against a wide array of micro-organisms.Methods:fresh henna samples were obtained from different regions of Oman as leaves and seeds,100 g fresh and dry leaves and SO g of fresh and dry seeds were separately soaked in 500 mL of ethanol for three days,respectively,with frequent agitation.The mixture was filtered,and the crude extract was collected.The crude extract was then heated,at 48 ℃ in a water bath to evaporate its liquid content.The dry crude henna extract was then tested for its antibacterial activity using well-diffusion antibiotic susceptibility technique.Henna extracts were investigated for their antibacterial activity at different concentrations against a wide array of different micro-organisms including a laboratory standard bacterial strain of Pseudomonas aeruginosa(NCTC 10662)(A aeruginosa) and eleven fresh clinical isolates of P.aeruginosa obtained from patients attending the Sultan Qaboos University Hospital(SQUH).2-Hydroxy-p-Nathoqinone-Tech(2-HPNT, MW=174.16,C_(10)H_40_3) was included as control(at 50%concentration) along with the henna samples tested.Results:Henna samples demonstrated antibacterial activity against all isolates but the highest susceptibility was against P.aeruginosa with henna samples obtained from Al-sharqyia region.Conclusions:Omani henna from Al-sharqyia region demonstrates high in vitro anti-P. aeruginosa activity compared with many henna samples from different regions of Oman. | Habbal O Hasson SS El-Hag AH Al-Mahrooqi Z Al-Hashmi N Al-Bimani Z MS Al-Balushi Al-Jabri AA | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 5 | Application of WEAP Simulation Model to Hengshui City Water Planning显示文摘Like many river basins in China, water resources in the Fudong Pai River are almost fully allocated. This paper seeks to assess and evaluate water resource problems using water evaluation and planning (WEAP) model via its application to Hengshui Basin of Fudong Pai River. This model allows the simulation and analysis of various water allocation scenarios and, above all, scenarios of users' behavior. Water demand management is one of the options discussed in detail. Simulations are proposed for diverse climatic situations from dry years to normal years and results are discussed. Within the limits of data availability, it appears that most water users are not able to meet all their requirements from the river, and that even the ecological reserve will not be fully met during certain years. But the adoption of water demand management procedures offers opportunities for remedying this situation during normal hydrological years. However, it appears that demand management alone will not suffice during dry years. Nevertheless, the ease of use of the model and its user-friendly interfaces make it particularly useful for discussions and dialogue on water resources management among stakeholders. | OJEKUNLE Z O 赵林 李满洲 杨真 谭欣 | 2007 | Transactions of Tianjin University2007，13，2： | 3 |
| 6 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 7 | Molecular pathways of liver regeneration:A comprehensive review显示文摘The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its volume.Although knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute injury.In liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver diseases.The current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic injuries.Subsequent studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases. | Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov | 2021 | World Journal of Hepatology2021，13，3： | 2 |
| 8 | Experimental investigation and flow visualization of the resin transfer mould filling process for non-woven hemp reinforced phenolic composites 显示文摘 | Richardson M O W Zhang Z Y | 2000 | Composites: Part A2000，31，12： | 2 |
| 9 | Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents显示文摘 | Fernanda Leit?o Suzana G. Leit?o Mara Zélia de Almeida Jéssica Cantos Tatiane Coelho Pedro Eduardo A. da Silva | 2013 | Journal of Ethnopharmacology2013，，： | 2 |
| 10 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 11 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 12 | Influence of particle size and dissolution conditions on the degradation properties of polylactideco-glycolide particles 显示文摘 | Dunne M Corrigan O I Ramtoola Z | 2000 | Biomaterials2000，21，： | 1 |
| 13 | New synthesis method of a Si nanocomposite anode for Li - ion batteries 显示文摘 | Laurence L O Monique T David Z | 2008 | Chem Mater2008，20，4： | 1 |
| 14 | Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120显示文摘 | Wang Z Pekarskaya O Bcnchcikh M | 2003 | Virol2003，312，1： | 1 |
| 15 | Discontinuous Sturm-Liouville Problems with Eigenparameter-dependent Boundary and Transmissions Conditions显示文摘 | Akdogan Z Demirci M Mukhtarov O S | 2005 | Acta Applicandae Mathematacae2005，86，3： | 1 |
| 16 | Anoikis and metastatic potential of cloudman S91 melanoma cells显示文摘 | Sanchez-Sweatman O Huang X | 2001 | Cancer Res2001，61，4： | 1 |
| 17 | Effects of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men显示文摘 | Marcin O Jadwiga S | 1996 | Atherosclerosis1996，121，： | 1 |
| 18 | Cohesive fracture modeling of elastic-plastic crack growth in functionally graded materials显示文摘 | Jin Z H Paulino O H Dodds Jr R H | 2003 | Engineering Fracture Mechanics2003，70，14： | 1 |
| 19 | A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 显示文摘 | Park H Li Z Yang X O | 2005 | Nat Immunol2005，6，11： | 1 |
| 20 | Retrospective population pharma cokinetic analysis of cetirizine in children aged 6 months to 12 years显示文摘 | Pitsiu M Hussein Z Majid O | 2004 | Br J Glin Pharmacol2004，57，4： | 1 |
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