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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Interoperability of Design Intent in Integrated Product and Process Design显示文摘Concurrent engineering is currently an overwhelming t rend in product development since it takes the down-stream product development issues and product life-cycle issues into consideration in up-front design pro cess. At this stage, evaluation, verification and validation of design concepts and design schemes is critical to the right-to-market product development. I dentification and extraction of design intent from the part digital mock-ups in different data formats and created in different CAD systems for DFX considerati on, evaluation, verification, and validation is crucial too. Traditionally, fro m manufacturing point of view, feature identification and extraction is to get t he features and feature-related information for manufacturing planning and inte gration. Presently, from the viewpoint of product development and product servi ce life cycle, design intent identification and extraction is to get all the des ign-related information for DFX consideration in early design stage, such as de sign for assembly, design for service, design for tooling, design for functional ity and design for environment etc. Therefore, how to successfully extract desi gn intent such as design and machining features and design-related information from the prototyping digital mock-ups created by different CAD systems for DFX consideration in upstream design stage is a very useful topic in integrated prod uct and process design and development. Presently, there are heterogeneous CAD systems in the market and the interoperat ion among the different CAD systems is indispensable. The interoperability of d ifferent CAD systems is by way of data exchanged technology such as STEP and IGE S. The critical weakness of this interoperation technology is that much of the design intent is lost in the interoperation process. Once the product digital m ock-ups is exchanged via data exchange technology such as IGES or STEP, the des ign intent including the dimension-driven design features and other attributes embedded in the part model are lost in the data translation process. Models rea d out of CAD systems come into other systems as featureless chunks of geometry e ntities. Obviously, the interoperation technology does not satisfy the industry need. It has been reported that this poor interoperation technology, which pro vides poor CAD models in neutral-format geometry had cost the automobile indust ry alone $1 billon per year. Fortunately, some researchers have been aware of t he criticality of this since only the United States industry spends billons of d ollars as a result of poor interoperability between computer-aided engineering software tools. In the past, product development was often done within a single company by co-located design team. In more recent years, there has been a busi ness paradigm shift in product development as the product development is being d one more often by geographically and temporally distributed design teams. There is a high level of outsourcing, not only of manufacturing but also of actual pr oduct development effort. Besides, product development across companies, and ev en within a single company, is often done within a heterogeneous software tool e nvironment. How to improve the interoperability of design intent created in het erogeneous software tool environment geographically has become a critical issue in next-generation product development system. Design intent in this research is defined as the outcome of design process. Des ign process goes from the identification of needs to satisfaction of that needs. Design intent satisfies this kind of needs. In this research, design intent i s created in a CAD system and embedded in part CAD model. The detailed design i ntent here includes design and manufacturing features and the feature-relat ed information such as feature parameters, feature relationships and some relate d characteristics such as associativity. Interoperability refers to the ability to share and communicate in the heterogeneous environment or heterogeneous soft | M W Fu W F Lu A Y C Nee S K Ong | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 2 |
| 3 | Moving element method for train-track dynamics显示文摘 | Koh C G Ong J S Y Chua D K H Feng J | 2003 | International Journal for Numerical Methods in Engineering2003，56，： | 1 |
| 4 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Water Research2003，37，： | 1 |
| 5 | Research frontier: memetic computation-past,present & future 显示文摘 | ONG Y S LIM M H CHEN Xian-shun | 2010 | IEEE Computational Intelli- gence Magazine2010，5，2： | 1 |
| 6 | Critical cooling rates for glass formation in Zr-Al-Cu-Ni alloys 显示文摘 | HNG H H LI Y NG S C ONG C K | 1996 | J Non-Cryst Solids1996，208，12： | 1 |
| 7 | Deposition of highly adhesive ZrO2 coating on Ti and CoCrMo implant materials using plasma spraying显示文摘 | Yang Y Ong J Tian J | 2003 | Biomaterials2003，24，： | 1 |
| 8 | Asian medical staff attitudes to- wards witnessed resuscitation 显示文摘 | Ong M Chan Y Srither D | 2004 | Resuscitation2004，60，： | 1 |
| 9 | Sentinel surveillance for human enterovirus 71 in Sarawak,Malaysia: lessons from the first 7 years 显示文摘 | Podin Y Gias EL Ong F | 2006 | BMC Public Health2006，6，： | 1 |
| 10 | Optimal planar evasive aircraft maneuvers against proportional navigation missiles 显示文摘 | Ong S Y Pierson B L | 1996 | Journal of Guidance Control and Dynamics1996，19，6： | 1 |
| 11 | Hybrid genetic algorithm and simulated annealing approach for the optimization of process plans for prismatic parts显示文摘 | LI W D ONG S K NEE A Y C | 2002 | International Journal of Product Research2002，40，8： | 1 |
| 12 | Reactive pulsed laser deposition of CNx films 显示文摘 | Zhao X -A Ong C W Tsang Y C | 1995 | Appl Phys Lett1995，66，： | 1 |
| 13 | Glass forming ability of bulk glass forming alloys显示文摘 | Li Y Ng S N Ong C K | 1997 | Scripta Material1997，36，7： | 1 |
| 14 | Low temperature character/zation of nano-sized BaFe12-2xZnxSnxO19 particlesJournal of Magnetism and Magnetic Materials显示文摘 | Fang H C Ong C K Zhang X Y | 1999 | Journal of Magnetism and Magnetic Materials1999，191，： | 1 |
| 15 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors 显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Water Res2003，37，3： | 1 |
| 16 | Double-skinned forward osmosis membranes for reducing internal concentration po- larization within the porous sublayer显示文摘 | Wang K Y Ong R C Chung T S | 2010 | Industrial and En- gineering Chemistry Research2010，49，10： | 1 |
| 17 | Fermentation of starch for en- protease pumilus strain 显示文摘 | Feng Y Yang W Ong S | 2001 | Applied Microbiology and Biotechnology2001，57，12： | 1 |
| 18 | Cardiac arrest and resuscitation epidemiology in Singapore (CARE I study)显示文摘 | Eng Hock Ong M Chan Y H Anantharaman V | 2003 | Prehosp Emerg Care2003，7，4： | 1 |
| 19 | Investigation of thermal benefits of rooftop garden in the tropical environment显示文摘 | Wong N H Chen Y Ong G L | 2003 | Build Environ2003，38，： | 1 |
| 20 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Wat Ros2003，37，14： | 1 |
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