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| 1 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
| 2 | Regulation of vascular endothelial growth factor(VEGF) -C and VEGF-D expression by the organ microenvironment in human colon carcinoma 显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Euro J Cancer2004，40，10： | 1 |
| 3 | Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma:correlation with clinicopathological parameters显示文摘 | Onogawa S Kitadai Y Amoika T | 2005 | Cancer Lett2005，226，1： | 1 |
| 4 | Expression of VEGF- C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Cancer Sci2004，95，1： | 1 |
| 5 | Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with elinicopathological parameters 显示文摘 | ONOGAWA S KITADAI Y AMIOKA T | 2005 | Cancer Lett2005，226，： | 1 |
| 6 | Expression of vascular endothelial growth factor (VEGF) - C and VEGF - D in early gastric carcinoma: Correlation with clinicopath- ological parameters显示文摘 | Onogawa S Kitadai Y Amioka T | 2005 | Cancer Letters2005，226，： | 1 |
| 7 | Expression of VEGF - C and VEGF - D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma 显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Cancer Sci2004，95，1： | 1 |
| 8 | Expression' of VEGF- C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with col-orectal carcinoma 显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Cancer Sci2004，95，1： | 1 |
| 9 | Bile acids repress E-cad- herin through the induction of Snail and increase cancer invasive- hess in human hepatobibiary carcinoma 显示文摘 | Fukase K Ohtsuka H Onogawa T | 2008 | Cancer Sci2008，99，9： | 1 |
| 10 | Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Cancer Sci2004，95，1： | 1 |
| 11 | Regulation of vascular endothelial growth factor (VEGF)-C and VEGF-D expression by the organ microenvironment in human colon carcinoma 显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Eur J Cancer2004，40，10： | 1 |
| 12 | Development of low friction piston with a new flexible skirt structure for a gasoline engine显示文摘 | SHIBUGA N ONOGAWA K AKASAKA Y | 2002 | SAE Paper2002，，01： | 1 |
| 13 | Expression of VEGF-C and VEGF-D at the invasive edge correlate with lymph node metastasis and prognosis of patients witll colarectal carcinoma 显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Cancer Sci2004，95，1： | 1 |
| 14 | Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma:correlation with clinicopathological parameters显示文摘 | ONOGAWA S KITADAI Y AMIOKA T | 2005 | Cancer Lett2005，226，1： | 1 |
| 15 | Regulation of vascular endothelial growth factor (VEGF)-C and VEGF-D expression by the organ microenvironment in human colon carcinoma显示文摘 | ONOGAWA S KITADAI Y TANAKA S | 2004 | Eur J Cancer2004，40，10： | 1 |
| 16 | Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma 显示文摘 | KITADAI Y ONOGAWA S KUWAI T | 2004 | Oncology Reports2004，11，2： | 1 |
| 17 | Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma:correlation with clinicopathological parameters显示文摘 | Onogawa S Kitadai Y Amioka T | 2005 | Cancer Lett2005，226，1： | 1 |
| 18 | Animal studies supporting the inhibition of mast cell activation by Eriobotrya japonica seed extract显示文摘 | Onogawa M Sun G C Takuma D | 2009 | Journal of Pharmacy and Pharmacology2009，61，2： | 1 |
| 19 | Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma 显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Cancer Sci2004，95，1： | 1 |
| 20 | Expression of vascular endothelial growth factor(VEGF)-C and VEGF-D in early gastric carcinoma :correlation with clinicopathological parameters 显示文摘 | Onogawa S Kitadai Y Amioka T | 2005 | Cancer Lett2005，226，： | 1 |
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