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| 1 | Hepatectomy for hepatocellular carcinoma with portal vein tumor thrombus显示文摘Despite surgical removal of tumors with portal vein tumor thrombus(PVTT) in hepatocellular carcinoma(HCC) patients, early recurrence tends to occur, and overall survival(OS) periods remain extremely short. The role that hepatectomy may play in long-term survival for HCC with PVTT has not been established. The operative mortality of hepatectomy for HCC with PVTT has also not been reviewed. Hence, we reviewed recent literature to assess these parameters. The OS of patients who received hepatectomy in conjunction with multidisciplinary treatment tended to be superior to that of patients who did not. Multidisciplinary treatments included the following: preoperative radiotherapy on PVTT; preoperative transarterial chemoembolization(TACE); subcutaneous administration of interferon-alpha(IFN-α) and intra-arterial infusion of 5-fluorouracil(5-FU) with infusion chemotherapy in the affected hepatic artery; cisplatin, doxorubicin and 5-FU locally administered in the portal vein; and subcutaneous injection of IFN-α, adjuvant chemotherapy(5-FU + Adriamycin) administration via the portal vein with postoperative TACE, percutaneous isolated hepatic perfusion and hepatic artery infusion and/or portal vein chemotherapy. The highest reported rate of operative mortality was 9.3%. In conclusion, hepatectomy for patients affected by HCC with PVTT is safe, has low mortality and might prolong survival in conjunction with multidisciplinary treatment. | Toshiya Kamiyama Tatsuhiko Kakisaka Tatsuya Orimo Kenji Wakayama | 2017 | World Journal of Hepatology2017，9，36： | 8 |
| 2 | Significance of functional hepatic resection rate calculated using 3D CT/^(99m)Tc-galactosyl human serum albumin singlephoton emission computed tomography fusion imaging显示文摘AIM: To evaluate the usefulness of the functional hepatic resection rate(FHRR) calculated using 3D computed tomography(CT)/^(99m)Tc-galactosyl-human serum albumin(GSA) single-photon emission computed tomography(SPECT) fusion imaging for surgical decision making. METHODS: We enrolled 57 patients who underwent bi- or trisectionectomy at our institution between October 2013 and March 2015. Of these, 26 patients presented with hepatocellular carcinoma, 12 with hilar cholangiocarcinoma, six with intrahepatic cholangiocarcinoma, four with liver metastasis, and nine with other diseases. All patients preoperatively underwent three-phase dynamic multidetector CT and ^(99m)Tc-GSA scintigraphy. We compared the parenchymal hepatic resection rate(PHRR) with the FHRR, which was defined as the resection volume counts per total liver volume counts on 3D CT/^(99m)Tc-GSA SPECT fusion images.RESULTS: In total, 50 patients underwent bisectionectomy and seven underwent trisectionectomy.Biliary reconstruction was performed in 15 patients, including hepatopancreatoduodenectomy in two. FHRR and PHRR were 38.6 ± 19.9 and 44.5 ± 16.0, respectively; FHRR was strongly correlated with PHRR. The regression coefficient for FHRR on PHRR was 1.16(P < 0.0001). The ratio of FHRR to PHRR for patients with preoperative therapies(transcatheter arterial chemoembolization, radiation, radiofrequency ablation, etc.), large tumors with a volume of > 1000 m L, and/or macroscopic vascular invasion was significantly smaller than that for patients without these factors(0.73 ± 0.19 vs 0.82 ± 0.18, P < 0.05). Postoperative hyperbilirubinemia was observed in six patients. Major morbidities(Clavien-Dindo grade ≥ 3) occurred in 17 patients(29.8%). There was no case of surgeryrelated death.CONCLUSION: Our results suggest that FHRR is an important deciding factor for major hepatectomy, because FHRR and PHRR may be discrepant owing to insufficient hepatic inflow and congestion in patients with preoperative therapies, macroscopic vascular invasion, and/or a tumor volume of > 1000 m L. | Yosuke Tsuruga Toshiya Kamiyama Hirofumi Kamachi Shingo Shimada Kenji Wakayama Tatsuya Orimo Tatsuhiko Kakisaka Hideki Yokoo Akinobu Taketomi | 2016 | World Journal of Gastroenterology2016，22，17： | 6 |
| 3 | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion显示文摘 | Akira Orimo Piyush B. Gupta Dennis C. Sgroi Fernando Arenzana-Seisdedos Thierry Delaunay Rizwan Naeem Vincent J. Carey Andrea L. Richardson Robert A. Weinberg | 2005 | Cell2005，，3： | 3 |
| 4 | Microstructural analyses of all-solid-state Li–S batteries using LiBH4-based solid electrolyte for prolonged cycle performance显示文摘Complex hydride materials have been widely investigated as potential solid electrolytes because they have good compatibility with the lithium metal anodes used in all-solid-state batteries. However, the development of all-solid-state batteries utilizing complex hydrides has been difficult as these cells tend to have short cycle lives. This study investigated the capacity fading mechanism of all-solid-state lithium–sulfur(Li–S) batteries using Li4(BH4)3I solid electrolytes by analyzing the cathode microstructure. Crosssectional scanning electron microscopy observations after 100 discharge–charge cycles revealed crack formation in the Li4(BH4)3I electrolyte and an increased cathode thickness. Raman spectroscopy indicated that decomposition of the Li4(BH4)3I solid electrolyte occurred at a constant rate during the cycling tests.To combat these effects, the cycle life of Li–S batteries was improved by increasing the amount of solid electrolyte in the cathode. | Kazuaki Kisu Sangryun Kim Ryuga Yoshida Hiroyuki Oguchi Naoki Toyama Shin-ichi Orimo | 2020 | Journal of Energy Chemistry2020，29，11： | 3 |
| 5 | Lithium ion conductivity of complex hydrides incorporating multiple closo–type complex anions显示文摘We report the lithium ionic conductivities of closo –type complex hydrides synthesized from various molar ratios of lithium borohydride(LiBH4) and decaborane(B10H14) as starting materials. The prepared closo –type complex hydrides comprised [B12H12]^2-, [B11H11]^2-, and [B10H10]^2- complex anions. In addition, increasing the LiBH4 content in the starting materials increased the amounts of [B11H11]^2- and [B10H10]^2-, leading to an improved ion conductivity of the prepared sample. The present study offers useful insights into strategies for controlling the complex anion composition in emerging solid electrolytes of closo-type complex hydrides at the molecular level, and improving their ionic conductivities. | Naoki Toyama Sangryun Kim Hiroyuki Oguchi Toyoto Sato Shigeyuki Takagi Masaru Tazawa Genki Nogami Shin-ichi Orimo | 2019 | Journal of Energy Chemistry2019，28，11： | 2 |
| 6 | High HbA1c is a risk factor for complications after hepatectomy and influences for hepatocellular carcinoma without HBV and HCV infection显示文摘Background:Currently,the population with type 2 diabetes mellitus(DM)is increasing worldwide.However,the influence of DM or hyperglycemia on the outcome of resected hepatocellular carcinoma(HCC)is unclear.Methods:We analyzed 756 patients with HCC who underwent hepatectomy.These patients were assigned to an HbA1c≥7.0%(H-A1c;n=100)or HbA1c<7.0%(L-A1c;n=656)group depending on their HbA1c level at admission.We investigated prognoses,clinicopathological characteristics and surgical outcomes including morbidities of HCC patients with high HbA1c,prognoses according to the treatment for DM were also investigated.Results:Among all patients and those with hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,overall survival(OS)and relapse-free survival(RFS)did not differ significantly between the H-A1c and L-A1c groups.In contrast,the 5-year OS rate of the H-A1c group was 55%and that of the L-A1c group 71%among patients without HBV and HCV(NBNC patients)(P=0.03).Among NBNC patients,the median RFS of the H-A1c group was 13 months,and that of the L-A1c group was 26 months(P=0.02).In addition,metformin use was an independent favorable factor for both OS and RFS.The H-A1c group had significantly higher rates of hyperbilirubinemia,wound infection,and pneumonia.Conclusions:HCC patients with high HbA1c might have poor prognoses for both survival and recurrence in NBNC-HCC.High HbA1c may also be a risk factor for morbidities after hepatectomy.Metformin use may constitute a good option for NBNC patients with HCC. | Shingo Shimada Toshiya Kamiyama Tatsuya Orimo Akihisa Nagatsu Hirofumi Kamachi Akinobu Taketomi | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 2 |
| 7 | Stromal fibroblasts in cancer:A novel tumor-promoting cell type显示文摘 | Weinberg RA | 2006 | Cell Cycle2006，5，15： | 1 |
| 8 | Li-N based hydrogen storage materials显示文摘 | Nakamori Y Orimo S.Mat | | 0，，108： | 1 |
| 9 | Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion 显示文摘 | Orimo A Gupta P B Sgroi D C | 2005 | Cell2005，121，3： | 1 |
| 10 | IIydroqcn propcrtics of the Mg2Ni syslcm syathes:zcd by rcaction mchanncial grinding,显示文摘 | Fujii | 1996 | J Alloys Compounds1996，23，2： | 1 |
| 11 | Hydrogen in the mechanically prepared nanostructured graphite显示文摘 | Orimo S Majer G Fukunaka T | 1999 | Appl Phys Lett1999，75，： | 1 |
| 12 | Destabilization of Li-based complex hydrides显示文摘 | Nakamori Y Orimo S | | 0，，370： | 1 |
| 13 | Efp as a primary estrogenresponsive gene in human breast cancer显示文摘 | Ikeda K Orimo A Higashi Y | 2000 | FEBS Lett2000，472，1： | 1 |
| 14 | Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion显示文摘 | Orimo A Gupta PB Sqroi DC | 2005 | Cell2005，121，3： | 1 |
| 15 | Cobalt-and copper-substitution effects on thermal stabilities and hydriding properties of amorphous MgNi显示文摘 | Ikeda K Orimo S | 1998 | JAlloysComp1998，280，： | 1 |
| 16 | Destabilization and enhanced dehydriding reaction of LiNH 2:an electronic structure viewpoint显示文摘 | Orimo S Nakamori Y Kitahara G Miwa K. Ohba N. Noritake T. Towata S | | 0，，79： | 1 |
| 17 | Reviewing the definition of elderly显示文摘 | Orimo H | 2006 | Nippon Ronen Igakkai Zasshi2006，43，1： | 1 |
| 18 | Dehydriding and rehydriding reactions of LiBH4 显示文摘 | Orimo S Nakamori Y Kitahara G | 2005 | J Alloys and Compounds2005，404，406： | 1 |
| 19 | The mechanism of mineralization and the role of alka- line phosphatase in health and disease 显示文摘 | Orimo H | 2010 | J Nippon Med Sch2010，77，1： | 1 |
| 20 | Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion显示文摘 | Orimo A Gupta PB Sgroi DC | 2005 | Cell2005，121，3： | 1 |
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