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	题名	作者	年代	出处	被引量
1	Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease.	Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg	2021	Cell Research2021，31，5：	2
2	Genetic variation at CYP3 A is associated with age at menarche and breast cancer risk: a case - control study 显示文摘	Johnson N Dudbridge F Orr N	2014	Breast Cancer lies2014，16，：	1
3	Updated American college of critical care Medicine - Pediatric advanced Life support guidelines for management of pediatric and neonatal septic shock relevance to the emergency care clinician 显示文摘	KISSOON N ORR RA CARCILLO JA	2010	Pediatr Emerg Care2010，26，11：	1
4	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24显示文摘	Yeager M Orr N Hayes RB	2007	Nat Genet2007，39，：	1
5	Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk显示文摘	Brennan K Garcias-Closas M Orr N	2012	Cancer Res2012，72，9：	1
6	Metal ioncomplexesofwater-solublecalixarenes显示文摘	ATWOOD J L ORR G W MEANS N	1992	Inorg Chem1992，31，4：	1
7	Prevalence of the genes for Shigella enterotoxins 1 and 2 among clinical isolates of Shigella in israel显示文摘	Yavzori M Cohen D Orr N	2002	Epidemiol Infect2002，128，3：	1
8	Commitment point during GOG1 that controls entry into the cell cycle 显示文摘	LEA N C ORR S J STOEBER K	2003	Mol Cell Biol2003，23，7：	1
9	Updated American College of Critical Care Medicine-pediatric advanced life support guidelines for management of pediatric and neonatal septic shock:Relevance to the emergency care clinician 显示文摘	Kissoon N Orr R A Carcillo J A	2010	Pediatr Emerg Care2010，26，11：	1
10	Selectibity of protein oxidative damage during aging in Drosophila melanogaster显示文摘	Das N Levine RL Orr WC		0，，：	1
11	Pharmacological characterization of an epibatidine binding site in the nerve cord of Periplnaeta americana 显示文摘	Orr N Shaffner A J Watson G B	1997	Pestic Biochem Physiol1997，58，：	1
12	Selectivity of protein oxidative damage during aging in drosophila melanogaster显示文摘	Das N Levine RL Orr WC	2001	Biochem J2001，360，1：	1
13	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 显示文摘	Yeager M Orr N Hayes RB	2007	Nat Genet2007，39，5：	1
14	Early removal of drains and discharge of breast cancer surgery patients:a controlled prospective clinical trial显示文摘	Murphy C Orr N	1995	Ann R Coll Surg Engl1995，77，：	1
15	Quantitative relationship between phenylalanine ammonia-lyase levels and phenylpropanoid accumulation in transgenic tobacco identifies a rate-determining step in natural product synthesis 显示文摘	BATE N ORR J NI W	1994	Proc Natl Acad Sci USA1994，91，：	1
16	Prevalence of the genes for Shigella enterotoxins 1 and 2 among clinical isolates of Shigella in Israel显示文摘	YAVZORI M COHEN D ORR N	2002	Epidemiol Infect2002，128，3：	1
17	Dilatational elasticity moduli of water-crude oil interfaces using the oscillating pendant drop 显示文摘	ASKE N ORR R SJOBLOM J	2002	Journal of Dispersion Science and Technology2002，23，6：	1
18	Driving to Work and Overweight and Obesity: Findings from the 2003 New South Wales Health Survey, Australia显示文摘	Wen L Orr N Millett C	2006	International Journal of Obesity2006，30，5：	1
19	Characterization and quantitative analysis of serum IgG class and subclass response to Shigella sonnei and Shigella flexneri 2a lipopolysaccharide following natural Shigella infection 显示文摘	Robin G Cohen D Orr N	1997	J Infect Dis1997，175，5：	1
20	查看详情显示文摘	MARQUES F M LABICHE M ORR N A		0，，：	1

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