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| 1 | Sleep,immunity and inflammation in gastrointestinal disorders显示文摘Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research endeavors.An estimated 70 million Americans suffer from some form of sleep disorder.Certain sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance detriments.Recent research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause mortality.Several research studies support the associations among sleep,immune function and inflammation.Here,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal disorders.Different physiologic processes including immune system and inflammatory cytokines help regulate the sleep.The inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep disturbances.On the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory cytokines.Alterations in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal cancer.In turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal diseases.Knowledge of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients. | Tauseef Ali James Choe Ahmed Awab Theodore L Wagener William C Orr | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-kb interval around the corneodesmosin gene (CDSN)显示文摘 | Orrù S Giuressi E Carcassi C | | 0，，01： | 1 |
| 3 | Combination of SHS and SPS techniques for fabrication of fully dense ZrB2-ZrC-SiC composites显示文摘 | Licheri R Orrù R Musa C | | 0，，03： | 1 |
| 4 | PAK signaling regulates oxidant-dependent NF-κB activation by flow显示文摘 | Orr AW Hahn C Blackman B R | | 0，，06： | 1 |
| 5 | Characteriza- tion of the interaction between the influenza A virus poly- merase subunit PB1 and the host nuclear import factor Ran- binding protein 5显示文摘 | Hutchinson E C Orr O E Man Liu S | 2011 | J Gen Virol2011，92，8： | 1 |
| 6 | The effect of a modified functional appliance on obstructive sleep apnea显示文摘 | Bonham P E Currier G F Orr W C | 1988 | Am J Orthod Dentofac Orthop1988，94，5： | 1 |
| 7 | Characterisation ofthree related low-temperature-regulated cDNAs from winterBrassica napus显示文摘 | Weretilnyk E Orr W White T C | 1993 | Plant Physiol1993，101，： | 1 |
| 8 | Phase behavior of CO2 and crude oil in low-temperature reservoirs显示文摘 | Orr F M Jr Yu A D Lien C L | 1981 | SPE Journal1981，21，4： | 1 |
| 9 | Pyrite removal from Illinois #6 coal by CrCl2 reduction and effect of pyrite on the coprecessing of Illinois #6 coal with waste automotive oil 显示文摘 | Shi Yanlong Orr E C Shao Lian Eyring E M | 1999 | Fuel Process Tech1999，59，23： | 1 |
| 10 | Communication across the curriculum in animal science 显示文摘 | Orr C L | 1996 | Journal of Animal Science1996，74，： | 1 |
| 11 | Anthropogenic ocean acidifi- cation over the twenty-first century and its impact on calcifying organisms显示文摘 | Orr J C Fabry V J Aumont O | 2005 | Nature2005，437，： | 1 |
| 12 | The effect of modified functional appliance on obstructive sleep apnea 显示文摘 | Bonham P E Currier G F Orr W C | 1988 | Am J Orthod Dento Fac Orthop1988，94，5： | 1 |
| 13 | Stream Ecosystem Re-sponse to Small Dam Removal:Lessons from the Heartland显示文摘 | Doyle M W Stanley E H Orr C H | 2005 | Geomorphology2005，71，12： | 1 |
| 14 | A DNA test to sex most birds显示文摘 | Griffiths R Double M C Orr K | 1998 | Molecular ecology1998，7，8： | 1 |
| 15 | A semi empirical model for prediction of how Post retained crowns will fail under compressive loading 显示文摘 | Mitehell C A Orr J F Kennedy J G | 1992 | J Dent Res1992，71，9： | 1 |
| 16 | Personality and motiva- tions associated with Facebook use显示文摘 | Ross C Orr E S Sisic M | 2009 | Computers in human be havior2009，25，2： | 1 |
| 17 | Robotically assisted total laparoscopic radical trachelectomy for fertility sparing in stage ⅠB1 adenosarcoma of the cervix显示文摘 | GEISLER J P ORR C J MANAHAN K J | 2008 | J Laparoendosc Adv Surg Tech A2008，18，5： | 1 |
| 18 | A DNA test to sex most birds显示文摘 | GRIFFITHS R DOUBLE M C ORR K | 1998 | Mol Ecol1998，7，8： | 1 |
| 19 | Phase Behavior of CG2 and Crude Oil in Low Temperature Reservoirs显示文摘 | ORR F M JR Yu A D Lien C L | 1981 | SPE Journal1981，21，4： | 1 |
| 20 | Personality and motivations associated with Facebook use显示文摘 | Ross C Orr ES Sisic M | 2009 | Comput Human Behav2009，25，2： | 1 |
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