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| 1 | Management and prevention of acute and chronic lateral ankle instability in athletic patient populations显示文摘Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance. | Brendan J Mc Criskin Kenneth L Cameron Justin D Orr Brian R Waterman | 2015 | World Journal of Orthopedics2015，6，2： | 20 |
| 2 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 3 | Thermodynamic functions of iron 显示文摘 | Orr R L Chipman J | 1967 | Trans AIME1967，239，： | 1 |
| 4 | Bayesian neural networkswith confidence estimations applied to data mining 显示文摘 | Orre R Lansner A Bate A | 2000 | Com- putational Statistics & Data Analysis2000，34，： | 1 |
| 5 | Combination of SHS and SPS techniques for fabrication of fully dense ZrB2-ZrC-SiC composites显示文摘 | Licheri R Orrù R Musa C | | 0，，03： | 1 |
| 6 | PAK signaling regulates oxidant-dependent NF-κB activation by flow显示文摘 | Orr AW Hahn C Blackman B R | | 0，，06： | 1 |
| 7 | Gender differences in premorbid adjustment of patients with first episode psychosis显示文摘 | Preston NJ Orr KG Date R | 2002 | Schizophr Res2002，55，： | 1 |
| 8 | Effect of ball milling on simultaneous spark plasma synthesis and densification of TiC-TiB2 composites显示文摘 | Locci A M Orr'u R Can G | 2006 | Materials Science and Engineering A2006，，434： | 1 |
| 9 | Perylene in basin sediments off southern California显示文摘 | ORR W L GRADY J R | 1967 | Geoehimica et Cosmochimica Acta1967，31，： | 1 |
| 10 | 显示文摘 | Luboshitzky R Lavie L Shen - Orr Z el al | 2005 | Obes Res2005，13，4： | 1 |
| 11 | Peach (Prunus persica) Endopolygalacturonase cDNA isolation and mRNA analysis in melting and nonmelting peach cultivers显示文摘 | LESTER D R SPEIRS J ORR G | 1994 | Plant Physiology1994，105，： | 1 |
| 12 | The use of amplified fragment length polymorphism (AFLP) in the isolation of sex-specific markers显示文摘 | Griffiths R Orr K | 1999 | Molecular Ecology1999，8，4： | 1 |
| 13 | The role of apoptosis in cell killing by cisplatin:a know cytometric study显示文摘 | Ormerod M G Orr R M Peacock J H | 1999 | Br J cancer1999，69，： | 1 |
| 14 | Respiratory mechanisms and timing during sleep in occlusive sleep apnea显示文摘 | Martin R Pennock B Orr W | 1980 | J Appl Physiol1980，48，： | 1 |
| 15 | Extending the methods used to screen the WHO drug safety database towards analysis of complex associations and improved accuracy for rare events显示文摘 | Nor6n GN Bate A Orre R | 2006 | Stat Med2006，25，21： | 1 |
| 16 | A comparison between maternal serum free beta-human chorionic gonadotrophin and pregnancy-associated plasma protein A levels in first-trimester twin and singleton pregnancies 显示文摘 | Mashiach R Orr U A Yaron Y | 2004 | Fetal Diagn Ther2004，19，2： | 1 |
| 17 | DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 显示文摘 | Rogakou E P Pilch D R Orr A H | 1998 | J Biol Chem1998，273，10： | 1 |
| 18 | A DNA test to sex most birds显示文摘 | Griffiths R Double M C Orr K | 1998 | Molecular ecology1998，7，8： | 1 |
| 19 | Interactions between cancer cells and the endothelium in metastasis显示文摘 | Orr F W Wang H H Lafrenie R M | 2000 | J Pathol2000，190，3： | 1 |
| 20 | DNA sex identification in the three-spined stickleback显示文摘 | Griffiths R Orr K J Adam A | 2000 | Journal of Fish Biology2000，57，5： | 1 |
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