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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine显示文摘 | Ireson CR Jones DJ Orr S | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，1： | 1 |
| 3 | Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-kb interval around the corneodesmosin gene (CDSN)显示文摘 | Orrù S Giuressi E Carcassi C | | 0，，01： | 1 |
| 4 | Characteriza- tion of the interaction between the influenza A virus poly- merase subunit PB1 and the host nuclear import factor Ran- binding protein 5显示文摘 | Hutchinson E C Orr O E Man Liu S | 2011 | J Gen Virol2011，92，8： | 1 |
| 5 | Acoustic field variability induced by time-evolving internal wave fields显示文摘 | Finette S Orr M H Turgut A | 2000 | J Acoust Soc Am2000，108，： | 1 |
| 6 | Individualism and collectivism in Israeli society: comparing religious and secular high-school students 显示文摘 | SAGY S ORR E BAR-ON D | 1999 | Human Relations1999，52，3： | 1 |
| 7 | Evaluation of antimicrobialantibiofilm activity of a hydrogen peroxide decontaminating system used in dental unit water lines显示文摘 | Orrù G Del Nero S Tuveri E | | 0，，： | 1 |
| 8 | Personality and motiva- tions associated with Facebook use显示文摘 | Ross C Orr E S Sisic M | 2009 | Computers in human be havior2009，25，2： | 1 |
| 9 | Impaired mitochondrial trafficking in Huntington’s disease显示文摘 | Li XJ Orr AL Li S | 2010 | Biochim Biophys Acta2010，1802，1： | 1 |
| 10 | Commitment point during GOG1 that controls entry into the cell cycle 显示文摘 | LEA N C ORR S J STOEBER K | 2003 | Mol Cell Biol2003，23，7： | 1 |
| 11 | Personality and motiva- tions associated with Facebook use显示文摘 | Ross C Orr E S Sisic M | 2009 | Computers m human be havior2009，25，2： | 1 |
| 12 | Improvement of LDLC laboratory values achieved by participation in a cardiac or diabetes disease management program 显示文摘 | Orr P Hobgoed A Coberley S | 2006 | Dis Manag2006，9，： | 1 |
| 13 | Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine显示文摘 | lreson C R Jones D J Orr S | 2002 | Cancer Epidemiol Biomarkers Prey2002，11，1： | 1 |
| 14 | Factors influen- cing stresses in the lumbar spine after the insertion of interver tebral cages:finite element analysis显示文摘 | Polikeit A Ferguson S J Nolte L P Orr T E | 2003 | Eur Spine J2003，12，： | 1 |
| 15 | Siglec-E is up-regulated andphosphorylated following lipopolysaccharide stimulation in order tolimit TLR-driven cytokine production 显示文摘 | Boyd CR Orr SJ Spence S | 2009 | J Immunol2009，183，12： | 1 |
| 16 | Solar ultraviolet radiation and the spawning habitat of yellow perch, Perca flavescens显示文摘 | WILLIAMSON C E HARGREAVES B R ORR P S | 1997 | Ecological Applications1997，7，： | 1 |
| 17 | An approach for time-dependent bone modeling and remodeling:theoretical development显示文摘 | ORR T E CARTER D R | 1990 | Journal of Orthopaedic Research1990，，8： | 1 |
| 18 | Storage of COz in saline aqui- fers : Effects of gravity, viscous, and capillary forces on amount and timing of trapping显示文摘 | Taku Ide S Jessen K Orr F M | 2007 | International Journal of Greenhouse Gas Control2007，1，4： | 1 |
| 19 | Ephs and ephrins resurface in inflammation, immunity, and atherosclerosis显示文摘 | Funk S D Orr A W | 2013 | Pharmacol Res2013，67，1： | 1 |
| 20 | Reducing MCM levels in human primary T cells during the G(0) - - > G( 1 ) transition causes genomic instability during the first cell cycle显示文摘 | Orr S J Gaymes T Ladon D | 2010 | Oncogene2010，29，26： | 1 |
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