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| 1 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 2 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 3 | Structure and properties of alkylammonium monolayers self-assembled on montmorillonite platelets 显示文摘 | Osman M A Ploetze M Skrabal P | 2004 | Journal of Physical Chemistry B2004，108，8： | 1 |
| 4 | Comparison of key enzymes in thezebra mussel,Dreissen a polymorpha,the earthworm Allolobophorachlorotica and Chironomus ripariuslarvae显示文摘 | OSMAN A M MVANNOORT P C | 2007 | Ecotoxicology andEnvironmental Safety2007，67，： | 1 |
| 5 | Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos显示文摘 | Bao J Lin H Ouyang Y Lei D Osman A Kim TW Mei L Dai P Ohlemiler KK Ambron RT | | 0，，： | 1 |
| 6 | Life cycle assessment study of solar PV systems:an example of a 27 kWp distributed solar PV system in Singapore显示文摘 | Kannan R Leong K C Osman R Ho H K Tso C P | | 0，，05： | 1 |
| 7 | Cardiac filling pressures are not ap- propriate to predict hemodynamic response to volume challenge 显示文摘 | Osman D Ridel C Ray P | 2007 | Cfit Care Med2007，35，1： | 1 |
| 8 | Imaging evaluation of maternal complicati- ons associated with repeat cesarean de- liveries显示文摘 | Moshiri M Osman S Bhargava P | 2014 | Radiol Clin North Am2014，52，5： | 1 |
| 9 | MicroRNA -214 contributes to melanoma tumour progression through suppression of TFAP2C显示文摘 | Penna E Orso F Cimino D Tenag|ia E Lembo A Quaglino E Poliseno L Haimovic A Osella-Abate S De Pitta C Pinatel E Stadler M B Provero P Bemengo M G Osman I Taverna D | 2011 | EMBO Journal2011，30，10： | 1 |
| 10 | Human gamma delta T cells:a lymphoid lineage capable of professional phagocytosis显示文摘 | Wu Y Wu W Wong WM Ward E Thrasher AJ Goldblatt D Osman M Digardz P Canaday DH Gustafsson K | 2009 | J Immunol2009，183，9： | 1 |
| 11 | Cardiac filling pressures are not appro-priate to predict hemodynamic response to volume challenge显示文摘 | Osman D Ridel C Ray P | 2007 | CritCare Med2007，35，1： | 1 |
| 12 | Renal artery stenosis:a cor-rectable cause of resistant hypertension显示文摘 | Dupler S Zack P M Osman A | 2012 | JAAPA2012，25，3： | 1 |
| 13 | Hrbird traveling wave/boundary protection for monopolar HVDC line显示文摘 | Liu Xiaolei Osman A H Malik O P | 2009 | IEEE Transactions on Power Delivery2009，24，2： | 1 |
| 14 | Thermal inactivation of tepary bean (Phaseolus acutifolius ), soybean and lima bean protease inhibitors: effect of acidic and basic pH显示文摘 | Osman M A Reid P M Weber C W | 2002 | Food Chemistry2002，78，4： | 1 |
| 15 | Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge 显示文摘 | I Osman D Ridel C Ray P | 2007 | Crit Care Med2007，35，1： | 1 |
| 16 | On the design of ejec-tors for deep hole machining 显示文摘 | Astakhov V P Suhramanva P S Osman M 0 M | 1996 | Tools Manufact1996，36，2： | 1 |
| 17 | Diffusion-weightec imaging of the liver: a comprehensive review显示文摘 | Mannelli L Bhargava P Osman SF | 2013 | Curr Probl Diagn Radiol2013，42，3： | 1 |
| 18 | Cardiac filling pressures are notappropriate to predict hemodynamic response to volume challenge显示文摘 | Osman D Ridel C Ray P et a1 | 2007 | Crit Care Med2007，35，： | 1 |
| 19 | Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge显示文摘 | Osman D Ridel C Ray P | 2007 | Crit Care Med2007，35，： | 1 |
| 20 | Thermal inactivation of tepary bean (Phaseolus acutifolius ), soybean and lima bean protease inhibitors:effect of acidic and basic pH显示文摘 | Osman M A Reid P M Weber C W | 2002 | Food Chemistry2002，78，： | 1 |
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