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| 1 | Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis显示文摘AIM To determine the effect of overexpression of fibrinogenlike protein 2(FGL2) on regulatory T cell(Treg) and effector T(Teff) cell function on T cell-induced colitis in Rag1-/-mice.METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2 Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/-mice. RESULTS In vitro, fgl2 Tg Treg had enhanced immunosuppressive activity, and fgl2 Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice(fgl2+/+) into Rag1-/-mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2 Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/-Treg were only partially protective. In mice that received fgl2 Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2 Tg mice did not produce colitis. CONCLUSION Here we show that fgl2 Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2 Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease. | Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy | 2017 | World Journal of Gastroenterology2017，23，15： | 2 |
| 2 | Placental transfer and decay of maternally acquired antimeasles antibodies in Nigerian children 显示文摘 | Hartter HK Oyedele OI Dietz K | 2000 | Pediatr Infect Dis J2000，19，7： | 1 |
| 3 | Passive immunity to measles in the breastmilk and cord blood of some Nigerian subjects 显示文摘 | Oyedele OO Odemuyiwa SO Ammerlaan W | 2005 | J Trop Pediatr2005，51，1： | 1 |
| 4 | Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa显示文摘 | Odemuyiwa SO Mulders MN Oyedele OI | 2001 | J Med Virol2001，65，3： | 1 |
| 5 | Soil physical and chemical properties under continuous maize cultiva- tion as influenced by hedgerow trees species on an alfisol in South Western Nigeria显示文摘 | Oyedele D J Awotoye O O Popoola S E | 2009 | African Journal of Agri- cultural Research2009，4，8： | 1 |
| 6 | Tillage effects on bulk density, hydraulic conductivity and strength of a loamy sand soil in southwest- ern Nigeria 显示文摘 | Osunbitan J A Oyedele D J Adekalu K O | 2005 | Soil and Tillage Research2005，82，1： | 1 |
| 7 | Protective levels of canine distemper virus antibody in urban dog population using plaque reduction neutralization test 显示文摘 | Onderstepoort J Vet Res Oyedele O I Oluwayelu D O | 2004 | 71 ( 3 ) : 227 - 2302004，71，3： | 1 |
| 8 | Tillage effects on bulk density, hydraulic conductivity and strength of a loamy sand soil in southwestern Nigeria显示文摘 | J.A. Osunbitan D.J. Oyedele K.O. Adekalu | | Soil & Tillage Research0，，： | 1 |
| 9 | Aggregation and organic matter fractions of three Nigerian soils as affected by soil disturbance and incorporation of plant material显示文摘 | Durodoluwa Joseph Oyedele Per Schjùnning Erik Sibbesen | 1999 | Soil and Tillage Research1999，50，2： | 1 |
| 10 | Tillage effects on bulk density,hydraulic conductivity and strength of a loamy sand soil in southweatern Nigeria显示文摘 | Osunbitan J A D J Oyedele K O Adekalu | 2005 | Soil and Tillage Besearch2005，，82： | 1 |
| 11 | Effect of osmotic pretreatment on air drying characteristics and color of pepper 显示文摘 | Kolawole Olumuyiwa Falade Olaniyi O Oyedele | 2010 | J Food Sic Technol2010，，： | 1 |
| 12 | Cooperative adoption of complex systems: a comprehen- sive model within and across networks 显示文摘 | ANGELA HAUSMAN WESLEY F FOHNSTON ADESEGUN OYEDELE | 2005 | Journal of Business & Industrial Marketing2005，20，45： | 1 |
| 13 | Co-morbidities associated with molar-incisor hypomineralisation in 8 to 16 year old pupils in Ile-Ife,Nigeria显示文摘 | Oyedele TA Folayan MO Adekoya-Sofowora CA | 2015 | BMC Oral Health2015，15，1： | 1 |
| 14 | Placental transfer and de- cay of maternally acquired antimeasles antibodies in Nigerian chil- dren显示文摘 | Hartter HK Oyedele OI Dietz K | 2000 | Pediatr Infect Dis J2000，19，7： | 1 |
| 15 | Total building perfo-rmance approach in building evaluation: a case study of an office building in Singapore 显示文摘 | OYEDELE L O KWOK Wai Tham FADEYI M O | 2011 | Journal of Energy Engineering2011，138，1： | 1 |
| 16 | University, education district, and schools collaboration in the preparation of local level educational leaders: the zimbabwean experience显示文摘 | QUARSHIE J D OYEDELE V | 2011 | Procedia - Social and Behavioral Sciences2011，29，： | 1 |
| 17 | Women's attitude to prenatal screening services for eongenltal abnormalities in Nigeria显示文摘 | Oloyede OAO Oyedele RA | 2008 | Journal of Obstetrics and Gynaecology2008，28，4： | 1 |
| 18 | Cooperative adoption of complex systems: A comprehensive model within and across networks显示文摘 | Hausman A Johnston W J Oyedele A | 2005 | Journal of Business & Industrial Marketing2005，20，45： | 1 |
| 19 | Formu- lation of an effective mosquito-repellent topical product from lcmong:'ass oil 显示文摘 | OYEDELE A O GBOLADE A A SOSAN M B | 2002 | Phytomedieine2002，9，3： | 1 |
| 20 | Avoiding Performance Failure Payment Deductions in PFI/PPP Projects: Model of Critical Success Factors显示文摘 | OYEDELE L O | 2013 | Journal of Performance of Constructed Facilities2013，27，3： | 1 |
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