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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Preventing Burnout in Mental Health Workers at Interpersonal Level : An Italian Pilot stuay 显示文摘 | Scamem P Bosco A Soleti E | 2009 | Community Ment Health J2009，45，： | 1 |
| 3 | Fasting and post-methioninehomocysteine levels in Alzheimers disease And vascu]ar dementia显示文摘 | Viiia P Bosco P Ferri E | 2009 | Int J Vitam Nutr ges2009，9，3： | 1 |
| 4 | Fasting and post-methionine homocysteine levels in Alzheimers disease and vascular dementia显示文摘 | Villa P Bosco P Ferri R | 2009 | Int J Vitam Nutr Res2009，79，3： | 1 |
| 5 | RFLP discordance in a PKUfamily due to a deletion in the PAH gene 显示文摘 | Bosco P Ceratto N Cali F | 1996 | Turk J Pediatr1996，38，4： | 1 |
| 6 | Morbidity associated with intraportal islet transplantation显示文摘 | Bucher P Mathe Z Bosco D | | 0，，04： | 1 |
| 7 | A clinical variant of familial Hermansky-Pudlak syndrome显示文摘 | Iannello S Fabbri G Bosco P | 2003 | Med Gen Med2003，5，1： | 1 |
| 8 | Low temperature hydrogenation of benzene and cyclohexene:A comparativestudy between γ-Al2O3 supported Pt-Co and Pt-Ni bimetallic catalysts显示文摘 | Lu S L Lonergan W W Bosco J P | | 0，，259： | 1 |
| 9 | Sequential kidney/islet transplantation:efficacy and safety assessment of a steroid-free immunosuppression protocol显示文摘 | Toso C Baertschiger R Morel P Bosco D Armanet M Wojtusciszyn A | | 0，，： | 1 |
| 10 | Ovulating induction methods in rabbit does:the pituitary and ovarian responses显示文摘 | Rebollar P.G Dal Bosco A Millàn P | | 0，，： | 1 |
| 11 | Levetiracetam versus car- bamazepine in patients with late poststroke seizures: amulti- center prospective randomized open-label study (EPIC Project) 显示文摘 | Consoli D Bosco D Postorino P | 2012 | Cerebrovasc Dis2012，34，4： | 1 |
| 12 | Association of IL-1 RN * 2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease显示文摘 | Bosco P Gueant Rodriguez RM Anello G | 2004 | J Neurosurg Psychiatry2004，75，7： | 1 |
| 13 | Audiogenic seizures susceptibility in transgemic mice with fragile X syndrome 显示文摘 | Musumeci S A Bosco P Colabrese G | 2000 | Epilepsia2000，41，： | 1 |
| 14 | Pharmacokinet- ics of a novel submicron budesonide dispersion for nebulized de- livery in asthma 显示文摘 | SHREWSBURY S B BOSCO A P USTER P S | 2009 | Int J Pharm2009，365，12： | 1 |
| 15 | Unexpected migration and oxidative eyclization of substituted 2-acetophenone triflates under basic conditions: synthetic and mechanistic insights显示文摘 | Coe J W Bianco K E Boscoe B P | 2003 | J Org Chem2003，68，26： | 1 |
| 16 | Chromosomal mapping of human cytokatin 13 gene显示文摘 | Romano V Raimondi E Bosco P | 1992 | Genomics1992，14，2： | 1 |
| 17 | Importance of cell-matrix interactions in rat islet-cell secretion in vitro显示文摘 | Bosco P Meda P Halban DA | 2000 | Diabetes2000，49，： | 1 |
| 18 | Amelioration of myoglobinuric renal damage in rats by chronic exposure to flavonol-rich red wine显示文摘 | Rodrigo R Bosco C Herrera P | 2004 | Nephrol Dial Transplant2004，6，： | 1 |
| 19 | A Nationwide Comparison of Driving Distance Versus Straight-Line Distance to Hospitals显示文摘 | Boscoe F P Henry K A Zdeb M S | 2012 | The Professional Geographer2012，64，20： | 1 |
| 20 | Protective glass coating for carbon-carbon composites显示文摘 | Isola C Appendino P Bosco F | 1998 | Carbon1998，36，78： | 1 |
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