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| 1 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 2 | 过度表达的内皮素1通过改变氧化应激加重糖尿病诱导的内皮功能障碍显示文摘内皮素1表达增加引起内皮功能障碍和氧化应激。通常糖尿病患者体内的血浆内皮素1水平增加。鉴于糖尿病患者的内皮功能障碍常先于血管并发症,研究者假设在血管内皮细胞中,内皮素1的过度表达会加莺糖尿病引起的血管内皮功能障碍。 | Idris-Khodja N Ouerd S Mian MO Gornitsky J Barhoumi T Paradis P Schiffrin EL 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 3 | Chemotherapy plus radiotherapy compared with radiotherapy alone in the treatment of locally advanced,unresectable,non-small cell lung cancer:a Meta-analysis显示文摘 | Robert S Pritchard EL Stephen P | 2009 | Annal Int Med2009，，： | 1 |
| 4 | Intravenous nesiritide a nat riuretic peptide in the treament of decompensated congestive heart failure显示文摘 | Colucci S El U Horton P | 2000 | New Engl J Med2000，343，4： | 1 |
| 5 | Serum cholesterol and depressive symptoms in elderly Finnish men 显示文摘 | Aijanseppa S Kivinen P Helkala EL | 2002 | Int J Geriatr Psychiatry2002，17，7： | 1 |
| 6 | Central nervous system hemangioblastomas, endolymphatic sac tumors, and yon Hippel-Lindau disease显示文摘 | Richard S David P Marsot-Dupuch K el al | 2000 | Neurosurg Rev2000，23，1： | 1 |
| 7 | D-opti- mal designs 显示文摘 | De Aguiar P 17 Bourguignon B Khots M S et el | 1995 | Chemometr Intdl Lab1995，30，2： | 1 |
| 8 | Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin显示文摘 | Brooks P C Stromblad S Klemke B el al | 1995 | J Clin Invest1995，96，4： | 1 |
| 9 | Benzimidazoisoquinolines: a newclass of rapidly metabolized aryl hydrocarbon receptor (AhR) ligandsthat induce AhR-dependcnt Tregs and prevent murine graftversus-hostdisease显示文摘 | Punj S Kopparapu P Jang H S el al | 2014 | PLoS 0^2014，9，88： | 1 |
| 10 | Atmosphere manifestation of tropical instability wave observed by QuikSCAT and tropical rain measuring missions显示文摘 | LIU W T XIE X POLITO P S at el | | Geophys Res Lett0，27，： | 1 |
| 11 | Chemotherapy plus Radiotherapy Alone in the Treatment of Locally Advanced, Unresectable, Non-Small-Cell Lung Cancer: a Meta-Analysis显示文摘 | Robert S Pritchard EL Stephen P | 2005 | Annal Int Med2005，129，3： | 1 |
| 12 | Hydrophobic effects on antibacterial and channel-forming properties of cecropin A-melittin hybrids显示文摘 | Juvvadi P Vunnam S Merrifield EL | | 0，，04： | 1 |
| 13 | A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone显示文摘 | L(O)PEZ ANDR(E)S N MARTIN FERNANDEZ B ROSSIGNOL P el al | | 0，，06： | 1 |
| 14 | Support vector machines for transient stability analysis of large -scale power systems 显示文摘 | Moulin L S da Silva A P A El -Sharkawi M A | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
| 15 | Expression of interleukin (IL)- 12 (p40)and IL- 12 (beta2) receptors in allergic rhinitis and chronic sinusitis 显示文摘 | Wright ED Christodoulopoulos P Frenkiel S el al | 1999 | Clin Exp Allergy1999，29，10： | 1 |
| 16 | Synthesis, characterization and development of high performance si- loxane - lnodified epoxy paints 显示文摘 | AHMAD S GUPTA A P Sharmiu E el al | 2005 | Progress in Organic Coatings2005，54，3： | 1 |
| 17 | Caspasedependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats显示文摘 | Marchand EL Der Sarkissian S Hamet P | 2003 | Circ Res2003，92，7： | 1 |
| 18 | One-, two-, and three-dimensional modeling of the different phases of wire array Z-pinch evolution显示文摘 | Chittenden J P Lebedev S V Bland S N el al | 2001 | Phys Plasmas2001，8，： | 1 |
| 19 | Binding of hepatitis C virus to CD81 显示文摘 | Piled P Uematsu Y Campagnoli S et el | 1998 | Science1998，282，： | 1 |
| 20 | Usage pat tern, glycemic improvement, hypoglycemia, and body mass index changes with sulfonylureas in real-life clinical practice: results rom OBSTACLE Hypoglycemia Study显示文摘 | Kalra S Deepak MC Narang P el al | 2013 | Diabetes Technol Ther2013，15，2： | 1 |
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