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| 1 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 2 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 3 | Dirac equation around a charged, rotating black hole 显示文摘 | PAGE D N | 1976 | Phys Rev: D1976，14，： | 2 |
| 4 | Serum concentrations of insulin-like growth factor-1,soluble tumor necrosis factor receptor-1 and angiogenin in endometriosis patients显示文摘 | Steff AM Gagne D Page M | 2004 | Am J Reprod Immunol2004，51，2： | 1 |
| 5 | Changing epidemiology of small-cell lung cancer in the United States over the last 30 years :anal- ysis of the surveillance, epidemiologic ,and end results database 显示文摘 | Govindan R Page N Morgensztern D | 2006 | J Clin Oncol2006，24，28： | 1 |
| 6 | Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes显示文摘 | Ghisalberti D Masi M Pages JM | 2005 | Biochem Biophys Res Commun2005，328，4： | 1 |
| 7 | Agent-based and analytical mode|ing to evaluate the effectiveness of green- belts 显示文摘 | BROWN D G PAGE S E RIOLO R | 2003 | Environmental Modeling & Software2003，19，12： | 1 |
| 8 | The molecular analysis of leaf senescence-A genomics approach显示文摘 | BUCHANAN-WOLLASTON V EARL S HARRISON E MATHAS E NAVABPOUR S PAGE T PINK D | 2003 | Plant Biotechnology Journal2003，1，： | 1 |
| 9 | Angiogenic/lymphangiogenic factors and adaptation to extreme altitudes during an expedition to Mount Everest显示文摘 | Patitucci M Lugrin D Pages G | 2009 | Acta Physiologica2009，196，2： | 1 |
| 10 | Complex regulation of the DNA-binding activity of p53 by phosphorylation:differential effects of individial phosphorylation sites on the interaction with different binding motifs显示文摘 | Hecker D Page G Lohrum M | 1996 | Oncogene1996，12，5： | 1 |
| 11 | Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-pos- terior wave显示文摘 | Menke D B Koubova J Page D C | 2003 | Dev Biol2003，262，2： | 1 |
| 12 | Maize DRE-binding proteins DBF1 and DBF2 are involved in rab17 regulation through the drought-responsive element in an ABA-dependent pathway显示文摘 | Kizis D Pages M | | 0，，06： | 1 |
| 13 | Changing epidemiology of small-cell lung cancer in the United States over the last 30years:Analysis of the Surveillance,Epidemiolngic and End-Results database显示文摘 | Govindan R Page N Morgensztern D et a1 | 2006 | J Clin Oncol2006，24，28： | 1 |
| 14 | Identification of an OprD homologue in Acinetobacter baumannii显示文摘 | DUPONT M PAGES J M LAFITTE D | 2005 | J Proteome Res2005，4，6： | 1 |
| 15 | Using measurements of muscle color,pH, and electrical impedance to augment the current USDA beef quality grading standards and improve the accuracy and precision of sorting carcasses into palatability groups 显示文摘 | Wulf D M Page J K | 2000 | Animal Science2000，，78： | 1 |
| 16 | Influences of calcium availability and tree species on Ca isotope fractionation in soil and vegetation 显示文摘 | Page B D Bullen T D Mitchell M J | 2008 | Biogeoehemistry2008，88，： | 1 |
| 17 | Distribution andweathering of crude oil residues on shorelines 18 years after theExxon Valdez spill显示文摘 | Boehm P D Page D S Brown J S | 2008 | Environmental Science&Technology2008，42，24： | 1 |
| 18 | Evaluation of marker-assisted selection through computer simulation 显示文摘 | EDWARDS M D Page N J | 1994 | Theor Appl Genet1994，88，： | 1 |
| 19 | Prognostic factors in breast cancer显示文摘 | Fitzgibbons PL Page DL Weaver D | 2000 | Arch Pathol Lab Med2000，124，7： | 1 |
| 20 | A survey of beef muscle color and pH显示文摘 | Page K J Wulf D M Schwotzer | 2001 | J Anim Sci2001，79，： | 1 |
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